nach oben

Erschienen in:

25.05.2022 | original article

Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis

A randomized controlled clinical trial

verfasst von: Érika Thatyana Nascimento Santana, Saulo da Cunha Machado, Viviane Nascimento Brandão Lima, Valter Joviniano DeSantana Filho, Leonardo Yung dos Santos Maciel, Jader Pereira de Farias Neto, Henrique Douglas Melo Coutinho, Natália Martins, Walderi Monteiro da Silva Júnior, Lucindo J. Quintans Júnior

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2023

Einloggen, um Zugang zu erhalten

Summary

Background

Knee osteoarthritis (OA) is characterized by a progressive degeneration of cartilage and menisci, leading to pain and locomotor disability. Here, we aimed to assess the effect of an exercise protocol and the oral use of non-hydrolyzed collagen (UC-II) on the functionality and quality of life of women with knee OA.

Material and methods

Individuals were divided into three groups (CG [control group]; MG [medication group]; EG [exercise group]). In the CG there was no intervention, while MG received an oral dose (1 capsule/day) of UC-II and the EG held 12 sessions of an exercise protocol.

Results

In the functionality tests (6-min walk test, 6MWT and timed up and go test [TUG]) the EG (p < 0.001/p = 0.020) and MG (p = 0.010/p = 0.010) revealed a significant improvement when compared to the CG. In the analysis of quality of life by WOMAC, a significant improvement was found only in the EG (p = 0.030) when compared to the CG; the same happened in the stiffness domain (EG, p = 0.010), despite in the pain domain, both the EG (p < 0.001) and the MG (p = 0.060) were better than the CG.

Conclusion

Data obtained here reveal that an exercise protocol and UC-II have similar effects for functionality, despite exercise being superior in promoting the quality of life score.

Vorheriger Artikel Effects of inspiratory muscle training on respiratory muscle strength, respiratory function and functional capacity in adolescents with idiopathic scoliosis

Nächster Artikel Patients’ perception of changes and consequences after tumor resection

WHO. 2019. https://www.who.int/chp/topics/rheumatic/en/. Accessed 2 Jan 2019.

Lo-Ciganic WH, et al. Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the osteoarthritis initiative. Osteoarthritis Cartilage. 2017;25:1390–8.PubMedPubMedCentral

Brosseau L. Ottawa panel evidence-based clinical practice guidelines for therapeutic exercise in the management of hip osteoarthritis. Clin Rehabil. 2016;30:935–46.PubMed

Fu K, Robbins SR, McDougall JJ. Osteoarthritis: the genesis of pain. Baillieres Clin Rheumatol. 2018;57:43–50.

Favrea F, Erhart-Hledik JC, Andriacchi TP. Age-related differences in sagittal-plane knee function at heel-strike of walking are increased in osteoarthritic patients. Osteoarthr Cartil. 2014;22:464–71.

Bannuru RR, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthr Cartil. 2019;27:1578–89.

Abbott JH, et al. Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee: a randomized controlled trial. 1: clinical effectiveness. Osteoarthr Cartil. 2015;21:525–34.

Allen KD, et al. STepped exercise program for patients with knee OsteoArthritis (STEP-KOA): protocol for a randomized controlled trial. BMC Musculoskelet Disord. 2019;20:254–60.PubMedPubMedCentral

Cho H, Walker A, Williams J, Hasty KA. Study of osteoarthritis treatment with antiinflammatory drugs: cyclooxygenase‑2 inhibitor and steroids. Biomed Res Int. 2015;2015:595273. https://doi.org/10.1155/2015/595273.CrossRefPubMedPubMedCentral

10.

Jevsevar DS. Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013;21:571–6.PubMed

11.

Mannelli LDC, Micheli L, Zanardelli M, Ghelardini C. Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord. 2013;14:228–37.

12.

Bagi CM, Berryman ER, Teo S, Lane NE. Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis. Osteoarthr Cartil. 2017;25:2080–90.

13.

Crowley DC, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6:312–21.PubMedPubMedCentral

14.

Bakilan F, et al. Effects of native type II collagen treatment on knee osteoarthritis: a randomized controlled trial. Eurasian J Med. 2016;48:95–102.PubMedPubMedCentral

15.

Saxby D, et al. The effects of load configuration, mass, and movement speed on biomechanical risk factors for musculoskeletal injuries. J Sci Med Sport. 2017;20:S174–S80.

16.

Hurley M, et al. Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review. Cochrane Database Syst Rev. 2018;4:CD10842.PubMed

17.

McAlindon T, et al. OARSI guidelines for the non-surgical management of knee. Osteoarthritis Cartilage. 2014;22:363–88.PubMed

18.

Juhl C, et al. Impact of exercise type and dose onpain and disability in knee osteoarthritisa systematic review and meta-regression analysis ofrandomized controlled trials. Arthritis Rheumatol. 2014;66:622–36.PubMed

19.

Geenen R, et al. EULAR recommendations for the health professional’s approach to pain management in inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018;77:797–807.PubMed

20.

Ahlbäck S. Osteoarthrosis of the knee. A radiographic investigation. Acta Radiol Diagn. 1968;277:7–72.

21.

Dobson F, et al. Reliability and measurement error of the osteoarthritis research society international (OARSI) recommended performance-based tests of physical function in people with hip and knee osteoarthritis. Osteoarthritis Cartilage. 2017;25:1792–6.PubMed

22.

Fransen M, et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;1:CD4376.PubMed

23.

Goh SL, et al. Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. Ann Phys Rehabil Med. 2019;62:356–63.PubMedPubMedCentral

24.

Skou T, Roos EM. Physical therapy for patients with knee and hip osteoarthritis: supervised, active treatment is current best practice. Clin Exp Rheumatol. 2019;37:112–7.PubMed

25.

Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000;30:87–8.PubMed

26.

Azeem MA, Patil R. The Study of undenatured type II collagen in the knee. Int J Orthop Traumatol Surg Sci. 2019;5:72–175.

27.

Barry E, et al. Is the timed up and go test a useful predictor of risk of falls in community dwelling older adults: a systematic review and meta-analysis. BMC Geriatr. 2014;14:1–14.

28.

Kenny RAM, et al. Summary of the updated American geriatrics society/British geriatrics society clinical practice guideline for prevention of falls in older persons. J Am Geriatr Soc. 2011;59:148–57.

29.

Delbaere K, et al. The risk of being fearful or fearless of falls in older people: an empirical validation. Disabil Rehabil. 2006;28:751–6.PubMed

30.

Benner RW, et al. Knee osteoarthritis: alternative range of motion treatment. Orthop Clin North Am. 2019;50:425–32.PubMed

31.

Sit RWS, et al. Clinic-based patellar mobilization therapy for knee osteoarthritis: a randomized clinical trial. Ann Fam Med. 2018;16:521–9.PubMedPubMedCentral

32.

Sambajon VV, et al. The effects of mechanical strain on synovial fibroblasts. J Oral Maxillofac Surg. 2003;61(6):707–12.PubMed

33.

Moss P, Sluka K, Wright A. The initial effects of knee joint mobilization on osteoarthritic hyperalgesia. Man Ther. 2007;12:109–18.PubMed

34.

Courtney CA, et al. Joint mobilization enhances mechanisms of conditioned pain modulation in individuals with osteoarthritis of the knee. J Orthop Sports Phys Ther. 2016;46:168–76.PubMed

35.

Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J. 2015;15:14–21.

36.

Lugo JP, et al. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013;10:48–59.PubMedPubMedCentral

37.

Prabhoo R, Billa G. Undenatured collagen type II for the treatment of osteoarthritis: a review. Int J Res Orthop. 2018;4:684–9.

38.

Stabile M, et al. Evaluation of the effects of undenatured type II collagen (UC-II) as compared to robenacoxib on the mobility impairment induced by osteoarthritis in dogs. Vet Sci. 2019;6:72–87.PubMedPubMedCentral

39.

van Meegeren MER, et al. IL‑4 alone and in combination with IL-10 protects against blood-induced cartilage damage. Osteoarthritis Cartilage. 2012;20:764–72.PubMed

40.

Li Y, et al. The effects of resistance exercise in patients with knee osteoarthritis: a systematic review and meta-analysis. Clin Rehabil. 2016;30:947–59.PubMed

41.

Musumeci G, et al. The effects of physical activity on apoptosis and lubricin expression in articular cartilage in rats with glucocorticoid-induced osteoporosis. J Bone Miner Metab. 2013;31:274–84.PubMed

42.

Musumeci G, Szychlinska MA, Herzog W. The “journal of functional morphology and kinesiology” journal club series: highlights on recent papers in exercise and osteoarthritis. J Funct Morphol Kinesiol. 2019;4:1–7.

43.

Silva C, et al. Feasibility of a home-based therapeutic exercise program in individuals with knee osteoarthritis. Arch Rheumatol. 2018;33:295–301.PubMedPubMedCentral

44.

Fingleton C, et al. Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23:1043–56.PubMed

45.

Fingleton C, Smart K, Doody C. Exercise-induced hypoalgesia in people with knee osteoarthritis with normal and abnormal conditioned pain modulation. Clin J Pain. 2017;33:395–404.PubMed

46.

Neblett R, et al. The central sensitization inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample. J Pain. 2013;14:438–45.PubMedPubMedCentral

47.

Bierke S, Petersen W. Influence of anxiety and pain catastrophizing on the course of pain within the first year after uncomplicated total knee replacement: a prospective study. Arch Orthop Trauma Surg. 2017;137:1735–42.PubMed

48.

Baliza GA, Lopes RA, Dias RC. The role of pain catastrophizing in prognosis and treatment of elderly with knee osteoarthritis: a critical literature review. Rev Bras Geriatr Gerontol. 2014;17:439–49.

49.

Perrot S, et al. Kinesiophobia e dor relacionada à fisioterapia na dor musculoesquelética: estudo de coorte multicêntrico nacional em pacientes e seus médicos em geral. Joint Bone Spine. 2018;85:101–7.PubMed

50.

Doménech J, Sanchis-Alfonso V, Espejo B. Changes in catastrophizing and kinesiophobia are predictive of changes in disability and pain after treatment in patients with anterior knee pain. Knee Surg Sports Traumatol Arthrosc. 2014;22:2295–300.PubMed

Titel: Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis
A randomized controlled clinical trial
verfasst von: Érika Thatyana Nascimento Santana
Saulo da Cunha Machado
Viviane Nascimento Brandão Lima
Valter Joviniano DeSantana Filho
Leonardo Yung dos Santos Maciel
Jader Pereira de Farias Neto
Henrique Douglas Melo Coutinho
Natália Martins
Walderi Monteiro da Silva Júnior
Lucindo J. Quintans Júnior
Publikationsdatum: 25.05.2022
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 11-12/2023
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-022-02037-8

Springer Medizin Österreich

Summary

Background

Material and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11-12/2023

Effects of inspiratory muscle training on respiratory muscle strength, respiratory function and functional capacity in adolescents with idiopathic scoliosis

Farewell to a pioneer of Austrian cardiovascular surgery: Univ. Prof. Dr. Manfred Deutsch (1939–2023)

MUW researcher of the month

MUW researcher of the month

Patients’ perception of changes and consequences after tumor resection

Correction to: Abstracts