Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.08.2015 | original article | Ausgabe 15-16/2015 Open Access

Wiener klinische Wochenschrift 15-16/2015

Clostridium difficile ribotypes in Austria: a multicenter, hospital-based survey

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 15-16/2015
Autoren:
PD Dr. Alexander Indra, MD Daniela Schmid, MD Steliana Huhulescu, MPH Erica Simons, MD Markus Hell, MD Karl Stickler, Univ.-Prof. Dr. Franz Allerberger, on behalf of the Austrian C. difficile Study Group
Wichtige Hinweise
*Collaborators: Ojan Assadian, Christoph Aspöck, Elisabeth Bischof, Susanne Equiluz-Bruck, Gebhard Feierl, Friederike Geppert, Monika Gilhofer, Gabriele Hartmann, Simone Höfler-Speckner, Oskar Janata, Uwe König, Monika Leeb, Andrea Lenger, Helga Masoud, Dorothea Orth, Ildiko-Julia Pap, Ulrike Pomper, Wolfgang Prammer, Lukas Reiter, Karl Silberbauer, Brigitte Stoiser, Heinz Stradal, Maria Szupancsitz, Herwig Tomantschger, Agnes Wechsler-Fördös, Gerhard Tucek, Astrid Urban, Eva-Maria Zeitlberger.

Summary

A prospective, noninterventional survey was conducted among Clostridium difficile positive patients identified in the time period of July until October 2012 in 18 hospitals distributed across all nine Austrian provinces. Participating hospitals were asked to send stool samples or isolates from ten successive patients with C.difficile infection to the National Clostridium difficile Reference Laboratory at the Austrian Agency for Health and Food Safety for PCR-ribotyping and in vitro susceptibility testing. A total of 171 eligible patients were identified, including 73 patients with toxin-positive stool specimens and 98 patients from which C. difficile isolates were provided. Of the 159 patients with known age, 127 (74.3 %) were 65 years or older, the median age was 76 years (range: 9–97 years), and the male to female ratio 2.2. Among these patients, 73 % had health care-associated and 20 % community-acquired C. difficile infection (indeterminable 7 %). The all-cause, 30-day mortality was 8.8 % (15/171). Stool samples yielded 46 different PCR-ribotypes, of which ribotypes 027 (20 %), 014 (15.8 %), 053 (10.5 %), 078 (5.3 %), and 002 (4.7 %) were the five most prevalent. Ribotype 027 was found only in the provinces Vienna, Burgenland, and Lower Austria. Severe outcome of C. difficile infection was found to be associated with ribotype 053 (prevalence ratio: 3.04; 95 % CI: 1.24, 7.44), not with the so-called hypervirulent ribotypes 027 and 078. All 027 and 053 isolates exhibited in vitro resistance against moxifloxacin. Fluoroquinolone use in the health care setting must be considered as a factor favoring the spread of these fluoroquinolone resistant C. difficile clones.
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 15-16/2015

Wiener klinische Wochenschrift 15-16/2015 Zur Ausgabe