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Erschienen in: Wiener klinische Wochenschrift 15-16/2017

01.08.2017 | original article

Clinical aspects of hantavirus infections in Bulgaria

verfasst von: I. Christova, M. Pishmisheva, I. Trifonova, N. Vatev, M. Stoycheva, M. Tiholova, D. Igova, M. Baev, R. Karagyaurova, U. Prokopova

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2017

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Summary

Background

Hantaviruses cause two distinct human diseases: hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe and hantavirus pulmonary syndrome (HPS) in America. In Europe, mainly Puumala, Dobrava and Seoul viruses cause HFRS. A total of 23 cases of HFRS were detected in Bulgaria over a 2‑year period 2013–2014. The aim of the study was to present epidemiology, clinical manifestations and laboratory findings of these patients.

Methods

Patients with HFRS were diagnosed using PCR, ELISA and immunoblotting tests.

Results

Dobrava-Belgrade virus (DOBV) was revealed as etiological agent in 16 (69.6%) patients and Puumala virus (PUUV) in 7 (30.4%) patients. All 23 patients were men aged 22–66 years of which 6 (26.1%) patients originated from regions in northern and western Bulgaria previously thought to be non-endemic. Patients with HFRS, despite the infecting hantavirus, manifested acute renal failure, asthenia and less pronounced hemorrhagic syndrome. Patients with DOBV infection were much more likely to present with arthromyalgia, severe headache, severe to moderately severe asthenoadynamia, abdominal pain, vomiting, hypotension, nervous system disorders as well as kidney enlargement, leucopenia and higher levels of blood creatinine, requiring hemodialysis procedures more often and for a longer period of time than patients with PUUV infection.

Conclusions

The present report describes for the first time comparative analysis of epidemiological features, clinical manifestations and laboratory findings of DOBV and PUUV infections in Bulgaria.

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Literatur
1.
Zurück zum Zitat Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A. Hantavirus infections in Europe. Lancet Infect Dis. 2003;3:653–61. CrossRefPubMed Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A. Hantavirus infections in Europe. Lancet Infect Dis. 2003;3:653–61. CrossRefPubMed
2.
Zurück zum Zitat Plyusnin A, Sironen T. Evolution of hantaviruses: Co-specification with reservoir hosts for more than 100 MYR. Virus Res. 2014;187:22–6. CrossRefPubMed Plyusnin A, Sironen T. Evolution of hantaviruses: Co-specification with reservoir hosts for more than 100 MYR. Virus Res. 2014;187:22–6. CrossRefPubMed
3.
Zurück zum Zitat Papa A, Vaheri A, LeDuc JW, Krüger DH, Avṧič-Županc T, Arikawa J, et al. Meeting report: Tenth international conference on hantaviruses. Antiviral Res. 2016;133:234–41. CrossRefPubMed Papa A, Vaheri A, LeDuc JW, Krüger DH, Avṧič-Županc T, Arikawa J, et al. Meeting report: Tenth international conference on hantaviruses. Antiviral Res. 2016;133:234–41. CrossRefPubMed
5.
Zurück zum Zitat Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YY, Morozov VG, Okulova VG, et al. Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerging Infect Dis. 2008;14:617–25. CrossRefPubMedPubMedCentral Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YY, Morozov VG, Okulova VG, et al. Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerging Infect Dis. 2008;14:617–25. CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Heyman P, Vaheri A, ENIVD members. Situation of hantavirus infections and haemorrhagic fever with renal syndrome in European countries as of December 2006. Euro Surveill. 2008;13:18925. PubMed Heyman P, Vaheri A, ENIVD members. Situation of hantavirus infections and haemorrhagic fever with renal syndrome in European countries as of December 2006. Euro Surveill. 2008;13:18925. PubMed
7.
Zurück zum Zitat Macneil A, Nichol ST, Spiropoulou CF. Hantavirus pulmonary syndrome. Virus Res. 2011;162:138–47. CrossRefPubMed Macneil A, Nichol ST, Spiropoulou CF. Hantavirus pulmonary syndrome. Virus Res. 2011;162:138–47. CrossRefPubMed
8.
Zurück zum Zitat Kamarinchev B, Monev V, Tiholova M. Hemorrhagic fever with renal syndrome. In: Serbezov VS, Kalvatchev A, editors. Viral hemorrhagic fevers and bioterrorism. Sofia: HMI ltd; 2005. pp. 143–58. in Bulgarian. Kamarinchev B, Monev V, Tiholova M. Hemorrhagic fever with renal syndrome. In: Serbezov VS, Kalvatchev A, editors. Viral hemorrhagic fevers and bioterrorism. Sofia: HMI ltd; 2005. pp. 143–58. in Bulgarian.
9.
Zurück zum Zitat Christova I, Plyusnina A, Gladnishka T, Kalvatchev N, Trifonova I, Dimitrov H, et al. Detection of Dobrava hantavirus RNA in Apodemus mice in Bulgaria. J Med Virol. 2015;87:263–8. CrossRefPubMed Christova I, Plyusnina A, Gladnishka T, Kalvatchev N, Trifonova I, Dimitrov H, et al. Detection of Dobrava hantavirus RNA in Apodemus mice in Bulgaria. J Med Virol. 2015;87:263–8. CrossRefPubMed
11.
Zurück zum Zitat Kramski M, Meisel H, Klempa B, Krüger DH, Pauli G, Nitsche A. Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing. Clin Chem. 2007;53:1899–905. CrossRefPubMed Kramski M, Meisel H, Klempa B, Krüger DH, Pauli G, Nitsche A. Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing. Clin Chem. 2007;53:1899–905. CrossRefPubMed
12.
Zurück zum Zitat Avṧič-Županc T, Korva M, Markotic A. HFRS and hantaviruses in the Balkans/South-East Europe. Virus Res. 2014;187:27–33. CrossRefPubMed Avṧič-Županc T, Korva M, Markotic A. HFRS and hantaviruses in the Balkans/South-East Europe. Virus Res. 2014;187:27–33. CrossRefPubMed
13.
Zurück zum Zitat Markotic A, Nichol ST, Kuzman I, Sanchez AJ, Ksiazek TG, Gagro A, et al. Characteristics of Puumala and Dobrava infections in Croatia. J Med Virol. 2002;66:542–51. CrossRefPubMed Markotic A, Nichol ST, Kuzman I, Sanchez AJ, Ksiazek TG, Gagro A, et al. Characteristics of Puumala and Dobrava infections in Croatia. J Med Virol. 2002;66:542–51. CrossRefPubMed
14.
Zurück zum Zitat Hukic M, Valjevac A, Tulumovic D, Numanovic F, Heyman P. Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: The impact on renal function. Eur J Clin Microbiol Infect Dis. 2011;30:381–5. CrossRefPubMed Hukic M, Valjevac A, Tulumovic D, Numanovic F, Heyman P. Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: The impact on renal function. Eur J Clin Microbiol Infect Dis. 2011;30:381–5. CrossRefPubMed
15.
Zurück zum Zitat Papa A, Antoniadis A. Hantavirus infections in Greece – an update. Eur J Epidemiol. 2001;17:189–94. CrossRefPubMed Papa A, Antoniadis A. Hantavirus infections in Greece – an update. Eur J Epidemiol. 2001;17:189–94. CrossRefPubMed
16.
Zurück zum Zitat Christova I, Younan R, Taseva E, Gladnishka T, Trifonova I, Ivanova V, et al. Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. Vector Borne Zoonotic Dis. 2013;13:188–92. CrossRefPubMed Christova I, Younan R, Taseva E, Gladnishka T, Trifonova I, Ivanova V, et al. Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. Vector Borne Zoonotic Dis. 2013;13:188–92. CrossRefPubMed
Metadaten
Titel
Clinical aspects of hantavirus infections in Bulgaria
verfasst von
I. Christova
M. Pishmisheva
I. Trifonova
N. Vatev
M. Stoycheva
M. Tiholova
D. Igova
M. Baev
R. Karagyaurova
U. Prokopova
Publikationsdatum
01.08.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1174-2