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Erschienen in: Wiener klinische Wochenschrift 15-16/2017

01.08.2017 | original article

Clinical aspects of hantavirus infections in Bulgaria

verfasst von: I. Christova, M. Pishmisheva, I. Trifonova, N. Vatev, M. Stoycheva, M. Tiholova, D. Igova, M. Baev, R. Karagyaurova, U. Prokopova

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2017

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Summary

Background

Hantaviruses cause two distinct human diseases: hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe and hantavirus pulmonary syndrome (HPS) in America. In Europe, mainly Puumala, Dobrava and Seoul viruses cause HFRS. A total of 23 cases of HFRS were detected in Bulgaria over a 2‑year period 2013–2014. The aim of the study was to present epidemiology, clinical manifestations and laboratory findings of these patients.

Methods

Patients with HFRS were diagnosed using PCR, ELISA and immunoblotting tests.

Results

Dobrava-Belgrade virus (DOBV) was revealed as etiological agent in 16 (69.6%) patients and Puumala virus (PUUV) in 7 (30.4%) patients. All 23 patients were men aged 22–66 years of which 6 (26.1%) patients originated from regions in northern and western Bulgaria previously thought to be non-endemic. Patients with HFRS, despite the infecting hantavirus, manifested acute renal failure, asthenia and less pronounced hemorrhagic syndrome. Patients with DOBV infection were much more likely to present with arthromyalgia, severe headache, severe to moderately severe asthenoadynamia, abdominal pain, vomiting, hypotension, nervous system disorders as well as kidney enlargement, leucopenia and higher levels of blood creatinine, requiring hemodialysis procedures more often and for a longer period of time than patients with PUUV infection.

Conclusions

The present report describes for the first time comparative analysis of epidemiological features, clinical manifestations and laboratory findings of DOBV and PUUV infections in Bulgaria.
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Metadaten
Titel
Clinical aspects of hantavirus infections in Bulgaria
verfasst von
I. Christova
M. Pishmisheva
I. Trifonova
N. Vatev
M. Stoycheva
M. Tiholova
D. Igova
M. Baev
R. Karagyaurova
U. Prokopova
Publikationsdatum
01.08.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1174-2

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