Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Spektrum der Augenheilkunde 6/2017

23.08.2017 | Angio-OCT / Medical Retina

Choroidal neovascularization in central serous chorioretinopathy—a new clinical entity

verfasst von: MD, PhD Zofia Michalewska, MD, PhD Karolina Dulczewska, MD, PhD Jerzy Nawrocki

Erschienen in: Spektrum der Augenheilkunde | Ausgabe 6/2017

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Purpose

To describe the morphology of retinal and choroidal vessels in swept source optical coherence tomography angiography (SS-OCTA) in choroidal neovascularization (CNV) during the course of central serous chorioretinopathy (CSC). Additionally, to report intravitreal anti-VEGF (vascular endothelial growth factor) injection treatment results.

Methods

A case series of patients diagnosed with chronic central serous chorioretinopathy. Fluorescein angiography, spectral domain optical coherence tomography, and SS-OCTA were performed. Analysis of retina and choroidal vasculature was performed. All patients received anti-VEGF therapy.

Results

The study demonstrated pathological vessels in the retina avascular zone and at the level of choriocapillaris during the course of choroidal neovascularization in central serous chorioretinopathy. These vessels are invisible in fluorescein angiography, as they are hidden by pooling of the dye. These vessels correspond to a slightly hyper-reflective elevation of retinal pigment epithelium visible in optical coherence tomography. Visual acuity and central retinal thickness decreased after anti-VEGF treatment. The vessels did not completely disappear despite anti-VEGF treatment.

Conclusion

This study shows that SS-OCTA enables us to identify neovessels during the course of CSC. In diagnosing this entity, SS-OCTA appears superior to fluorescein angiography and might also enable us to decide on the best timing for anti-VEGF injections.
Literatur
1.
Zurück zum Zitat Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher Y, Guyer DR, Slakter JS, Sorenson JA, Orlock DA. Central serous chorioretinopathy in younger and older adults. Ophthalmology. 1996;103:2070–9. discussion 79–80. CrossRefPubMed Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher Y, Guyer DR, Slakter JS, Sorenson JA, Orlock DA. Central serous chorioretinopathy in younger and older adults. Ophthalmology. 1996;103:2070–9. discussion 79–80. CrossRefPubMed
2.
Zurück zum Zitat Colucciello M. Choroidal neovascularization complicating photodynamic therapy for central serous retinopathy. Retina (Philadelphia, Pa). 2006;26(2):239–42. CrossRef Colucciello M. Choroidal neovascularization complicating photodynamic therapy for central serous retinopathy. Retina (Philadelphia, Pa). 2006;26(2):239–42. CrossRef
3.
Zurück zum Zitat Loo RH, Scott IU, Flynn HW Jr, Gass JD, Murray TG, Lewis ML, Rosenfeld PJ, Smiddy WE. Factors associated with reduced visual acuity during long-term follow-up of patients with idiopathic central serous chorioretinopathy. Retina (Philadelphia, Pa). 2002;22(1):19–24. CrossRef Loo RH, Scott IU, Flynn HW Jr, Gass JD, Murray TG, Lewis ML, Rosenfeld PJ, Smiddy WE. Factors associated with reduced visual acuity during long-term follow-up of patients with idiopathic central serous chorioretinopathy. Retina (Philadelphia, Pa). 2002;22(1):19–24. CrossRef
4.
Zurück zum Zitat Fung AT, Yannuzzi LA, Freund KB. Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina (Philadelphia, Pa). 2012;32(9):1829–37. CrossRef Fung AT, Yannuzzi LA, Freund KB. Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina (Philadelphia, Pa). 2012;32(9):1829–37. CrossRef
5.
Zurück zum Zitat Cakir B, Reich M, Lang SJ, Bühler A, Stahl A, Böhringer D, Agostini H, Lange C. Possibilities and Limitations of OCT-Angiography in Patients with Central Serous Chorioretinopathy. Klin Monbl Augenheilkd. 2017; doi: 10.​1055/​s-0043-102576. Cakir B, Reich M, Lang SJ, Bühler A, Stahl A, Böhringer D, Agostini H, Lange C. Possibilities and Limitations of OCT-Angiography in Patients with Central Serous Chorioretinopathy. Klin Monbl Augenheilkd. 2017; doi: 10.​1055/​s-0043-102576.
6.
Zurück zum Zitat Weng S, Mao L, Yu S, Gong Y, Cheng L, Chen X. Detection of choroidal neovascularization in central serous chorioretinopathy using optical coherence tomographic angiography. Ophthalmologica. 2016;236(2):114–21. CrossRefPubMed Weng S, Mao L, Yu S, Gong Y, Cheng L, Chen X. Detection of choroidal neovascularization in central serous chorioretinopathy using optical coherence tomographic angiography. Ophthalmologica. 2016;236(2):114–21. CrossRefPubMed
8.
Zurück zum Zitat Mudvari SS, Goff MJ, Fu AD, McDonald HR, Johnson RN, Ai E, Jumper JM. The natural history of pigment epithelial detachment associated with central serous chorioretinopathy. Retina (Philadelphia, Pa). 2007;27:1168–73. CrossRef Mudvari SS, Goff MJ, Fu AD, McDonald HR, Johnson RN, Ai E, Jumper JM. The natural history of pigment epithelial detachment associated with central serous chorioretinopathy. Retina (Philadelphia, Pa). 2007;27:1168–73. CrossRef
9.
Zurück zum Zitat Schatz H, Madeira D, Johnson RN, McDonald HR. Central serous chorioretinopathy occurring in patients 60 years of age and older. Ophthalmology. 1992;99:63–7. CrossRefPubMed Schatz H, Madeira D, Johnson RN, McDonald HR. Central serous chorioretinopathy occurring in patients 60 years of age and older. Ophthalmology. 1992;99:63–7. CrossRefPubMed
10.
Zurück zum Zitat Peiretti E, Ferrara DC, Caminiti G, Mura M, Hughes J. Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy. Retina (Philadelphia, Pa). 2015;35(7):1360–7. CrossRef Peiretti E, Ferrara DC, Caminiti G, Mura M, Hughes J. Choroidal neovascularization in caucasian patients with longstanding central serous chorioretinopathy. Retina (Philadelphia, Pa). 2015;35(7):1360–7. CrossRef
11.
Zurück zum Zitat Chhablani J, Pichi F, Silva R, Casella AM, Murthy H, Banker A, Nowilaty SR, Carrai P, Nucci P, Arevalo JF, King Khaled Eye Specialist Hospital International Collaborative Retina Study Group. Antiangiogenics in choroidal neovascularization associated with laser in central serous chorioretinopathy. Retina (Philadelphia, Pa). 2016;36(5):901–8. doi: 10.​1097/​iae.​0000000000000804​. CrossRef Chhablani J, Pichi F, Silva R, Casella AM, Murthy H, Banker A, Nowilaty SR, Carrai P, Nucci P, Arevalo JF, King Khaled Eye Specialist Hospital International Collaborative Retina Study Group. Antiangiogenics in choroidal neovascularization associated with laser in central serous chorioretinopathy. Retina (Philadelphia, Pa). 2016;36(5):901–8. doi: 10.​1097/​iae.​0000000000000804​. CrossRef
12.
Zurück zum Zitat Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH. Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina (Philadelphia, Pa). 2015;35(11):2219–28. CrossRef Coscas GJ, Lupidi M, Coscas F, Cagini C, Souied EH. Optical coherence tomography angiography versus traditional multimodal imaging in assessing the activity of exudative age-related macular degeneration: a new diagnostic challenge. Retina (Philadelphia, Pa). 2015;35(11):2219–28. CrossRef
Metadaten
Titel
Choroidal neovascularization in central serous chorioretinopathy—a new clinical entity
verfasst von
MD, PhD Zofia Michalewska
MD, PhD Karolina Dulczewska
MD, PhD Jerzy Nawrocki
Publikationsdatum
23.08.2017
Verlag
Springer Vienna
Erschienen in
Spektrum der Augenheilkunde / Ausgabe 6/2017
Print ISSN: 0930-4282
Elektronische ISSN: 1613-7523
DOI
https://doi.org/10.1007/s00717-017-0363-8