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Chondrosarcoma of the spine—a case report

verfasst von: Sebastian Simon, Heinrich Resch, Friedrich Lomoschitz, Bernhard J. H. Frank, Assoc. Prof. PD Roland Kocijan, MD

Erschienen in: Wiener Medizinische Wochenschrift

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Summary

Case

A 73-year-old male patient presented with a 3-month history of back pain. In bone scintigraphy and the FDG PET-CT scan (fluorodeoxyglucose positron-emission computed tomography), highly suspect uptake levels were found in TH12-L1. Accordingly, an osteodestructive process was found on MRI (magnetic resonance imaging). Following a successfully performed biopsy of TH12, histologic analysis of the bone material revealed a chondrosarcoma (G1; T4N2M0). Complete resection of the tumor was successfully performed, since chondrosarcoma are resistant to radiation and chemotherapy.

Conclusion

As chondrosarcoma is a rare bone neoplasm, it must be considered in the differential diagnosis of lower back pain to initiate adequate treatment.

Wu A, March L, Zheng X, Huang J, Wang X, Zhao J, et al. Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. Ann Transl Med.8:299–299.

Hadzimuratovic B, Mittelbach A, Bahrami A, Zwerina J, Kocijan R. Confluent abscesses in autochthonous back muscles after spinal injections. Wien Med Wochenschr. 2020; https://doi.org/10.1007/s10354-020-00773-y. CrossRefPubMed

Finucane LM, Downie A, Mercer C, Greenhalgh SM, Boissonnault WG, Pool-Goudzwaard AL, et al. International framework for red flags for potential serious spinal pathologies. J Orthop Sports Phys Ther. 2020;50:350–72. https://doi.org/10.2519/jospt.2020.9971. CrossRefPubMed

Redondo A, Bagué S, Bernabeu D, Ortiz-Cruz E, Valverde C, Alvarez R, et al. Malignant bone tumors (other than Ewing’s): clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS). Cancer Chemother Pharmacol. 2017;80:1113–31. https://doi.org/10.1007/s00280-017-3436-0. CrossRefPubMedPubMedCentral

Staals EL, Bacchini P, Bertoni F. Dedifferentiated central chondrosarcoma. Cancer. 2006;106:2682–91. https://doi.org/10.1002/cncr.21936. CrossRef

Strike SA, McCarthy EF. Chondrosarcoma of the spine: a series of 16 cases and a review of the literature. Iowa Orthop J. 2011;31:154–9. PubMedPubMedCentral

Weinschenk RC, Wang W‑L, Lewis VO. Chondrosarcoma. J Am Acad Orthop Surg. 2021;29:553–62. https://doi.org/10.5435/JAAOS-D-20-01188. CrossRefPubMed

Pennington Z, Ehresman J, Pittman PD, Ahmed AK, Lubelski D, McCarthy EF, et al. Chondrosarcoma of the spine: a narrative review. Spine J. 2021;21(12):2078–96. https://doi.org/10.1016/j.spinee.2021.04.021 CrossRefPubMed

Nazeri E, Gouran Savadkoohi M, Majidzadeh‑A K, Esmaeili R. Chondrosarcoma: An overview of clinical behavior, molecular mechanisms mediated drug resistance and potential therapeutic targets. Crit Rev Oncol Hematol. 2018;131:102–9. CrossRef

10.

Rozeman LB, Hogendoorn PC, Bovée JV. Diagnosis and prognosis of chondrosarcoma of bone. Expert Rev Mol Diagn. 2002;2:461–72. https://doi.org/10.1586/14737159.2.5.461. CrossRefPubMed

11.

Gorlick RGM, Toretsky JA, Neyssa M, Wolden SL, Randall RL, Gebhardt MC, Teot LA, Bernstein MM. Holland-Frei cancer medicine. 6th ed. 2003.

12.

Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing’s sarcoma. Clin Orthop Relat Res. 2007;459:40–7. CrossRef

13.

Lugowska I, Teterycz P, Mikula M, Kulecka M, Kluska A, Balabas A, et al. IDH1/2 mutations predict shorter survival in chondrosarcoma. J Cancer. 2018;9:998–1005. CrossRef

14.

Fromm J, Klein A, Baur-Melnyk A, Knösel T, Lindner L, Birkenmaier C, et al. Survival and prognostic factors in conventional central chondrosarcoma. BMC Cancer. 2018;18:849. https://doi.org/10.1186/s12885-018-4741-7. CrossRefPubMedPubMedCentral

15.

Liu C, Xi Y, Li M, Jiao Q, Zhang H, Yang Q, et al. Dedifferentiated chondrosarcoma: Radiological features, prognostic factors and survival statistics in 23 patients. PLoS ONE. 2017; https://doi.org/10.1371/journal.pone.0173665. CrossRefPubMedPubMedCentral

16.

Le A, Ball D, Pitman A, Fox R, King K. Chondrosarcoma of bone complicating Ollier’s disease: Report of a favourable response to radiotherapy. Australas Radiol. 2003;47:322–4. https://doi.org/10.1046/j.1440-1673.2003.01187.x. CrossRefPubMed

17.

Murphey MD, Walker EA, Wilson AJ, Kransdorf MJ, Temple HT, Gannon FH. From the archives of the AFIP. Radiographics. 2003;23:1245–78. https://doi.org/10.1148/rg.235035134. CrossRefPubMed

18.

Zhang Q, Xi Y, Li D, Yuan Z, Dong J. The utility of 18F-FDG PET and PET/CT in the diagnosis and staging of chondrosarcoma: a meta-analysis. J Orthop Surg Res. 2020;15:229. https://doi.org/10.1186/s13018-020-01748-w. CrossRefPubMedPubMedCentral

19.

Nunna RS, Patel S, Patil SN, Ansari D, Burch TG, Mehta AI, et al. Incidence, management, and outcomes of adult patients with spinal Chondrosarcoma in the United States. World Neurosurg. 2021;149:316–28. CrossRef

20.

Sallabanda M, Garcia R, Lorenzana L, Santaolalla I, Abarca J, Sallabanda K. Treatment of chordomas and chondrosarcomas with CyberKnife Robotic hypofractionated radiosurgery: a single institution experience. 2021. https://www.cureus.com/articles/67156-treatment-of-chordomas-and-chondrosarcomas-with-cyberknife-robotic-hypofractionated-radiosurgery-a-single-institution-experience. Accessed: 11 Oct 2021.

21.

Nielsen PR, Jørgensen LD, Dahl B, Pedersen T, Tønnesen H. Prehabilitation and early rehabilitation after spinal surgery: randomized clinical trial. Clin Rehabil. 2010;24:137–48. https://doi.org/10.1177/0269215509347432. CrossRefPubMed

Titel: Chondrosarcoma of the spine—a case report
verfasst von: Sebastian Simon
Heinrich Resch
Friedrich Lomoschitz
Bernhard J. H. Frank
Assoc. Prof. PD Roland Kocijan, MD
Publikationsdatum: 04.02.2022
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-021-00897-9

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Chondrosarcoma of the spine—a case report

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