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Erschienen in: Wiener klinische Wochenschrift 21-22/2021

21.10.2021 | original article

Chemobrachyradiotherapy and consolidation chemotherapy in treatment of locally advanced cervical cancer

A retrospective single institution study

verfasst von: MD Krešimir Tomić, Gordana Berić Jozić, Ana Parić, Inga Marijanović, Ivan Lasić, Dragan Soldo, Eduard Vrdoljak

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2021

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Summary

Background

Given the lack of primary and secondary prevention programs and cancer awareness in general, cervical cancer remains one of the main causes of cancer-related death in developing countries, such as Bosnia and Herzegovina. Optimization of combinations of external radiation therapy (ERT), brachytherapy and chemotherapy is still needed to improve outcomes in the treatment of advanced cervical cancer.

Patients and methods

We retrospectively analyzed 48 consecutive patients with Fédération Internationale de Gynecologie et d’Obstetrique (FIGO) 2009 stage IB2-IVA, who were treated with primary concomitant chemobrachyradiotherapy (CCBRT) and consolidation chemotherapy at the Department of Oncology, University Hospital Mostar, Bosnia and Herzegovina between December 2012 and June 2020. Patients were treated with ERT plus two cycles of concomitant chemobrachytherapy with ifosfamide and cisplatin and low-dose rate (LDR) brachytherapy followed by four cycles of consolidation chemotherapy at 3‑week intervals. We evaluated local control rate (LCR), disease-free survival (DFS), overall survival (OS), disease-specific survival (DSS) and toxicity.

Results

After 45.5 months (interquartile range, IQR = 47 months) of median follow-up, 5‑year DFS was 72.8% (95% confidence interval. CI 59–78%), OS was 76.6% (95% CI 60–79%), and DSS was 88% (95% CI 71–86%) with acceptable toxicity. LCR was 94%.

Conclusion

Primary CCBRT and consolidation chemotherapy applied in standard clinical practice in the treatment of locally advanced cervical cancer (LACC) produce respectable outcomes.

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Literatur
24.
Zurück zum Zitat Jelavić TB, Miše BP, Strikic A, Ban M, Vrdoljak E. Adjuvant chemotherapy in locally advanced cervical cancer after treatment with concomitant chemoradiotherapy—room for improvement? Anticancer Res. 2015;35:4161–5. PubMed Jelavić TB, Miše BP, Strikic A, Ban M, Vrdoljak E. Adjuvant chemotherapy in locally advanced cervical cancer after treatment with concomitant chemoradiotherapy—room for improvement? Anticancer Res. 2015;35:4161–5. PubMed
Metadaten
Titel
Chemobrachyradiotherapy and consolidation chemotherapy in treatment of locally advanced cervical cancer
A retrospective single institution study
verfasst von
MD Krešimir Tomić
Gordana Berić Jozić
Ana Parić
Inga Marijanović
Ivan Lasić
Dragan Soldo
Eduard Vrdoljak
Publikationsdatum
21.10.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01958-0