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Erschienen in:

01.09.2022 | editorial

CAR-T cells—Real-time experience applying CAR-T cells—What we have learned so far

verfasst von: Univ.-Prof. Dr. Hildegard Greinix

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2022

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Excerpt

CD19-targeted chimeric antigen receptor-engineered(CAR)‑T cells are novel therapies showing great promise for patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL), primary mediastinal B cell lymphoma, mantle cell lymphoma, and follicular lymphoma. EMA-approved and commercially available CAR‑T cell products have been used successfully by qualified CAR‑T cell centers worldwide and these real world data compare favorably to pivotal study results with overall response rates (ORR) and complete response rates (CR) ranging from 51–93% and 40–64%, respectively [19]. …
Literatur
11.
Zurück zum Zitat Kamdar M, Solomon SR, Arnason J, et al. Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B‑cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial. Lancet. 2022;399(10343):2294–308. https://doi.org/10.1016/S0140-6736(22)00662-6.CrossRefPubMed Kamdar M, Solomon SR, Arnason J, et al. Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B‑cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial. Lancet. 2022;399(10343):2294–308. https://​doi.​org/​10.​1016/​S0140-6736(22)00662-6.CrossRefPubMed
13.
Zurück zum Zitat Martin T, Usmani SZ, Berdeja JG, et al. Updated results from CARTITUDE-1: Phase 1b/2 study of ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T cell therapy, in patients with relapsed/refractory multiple myeloma. Abstract 549. In: 63rd ASH Annual Meeting & Exposition. 2021. Martin T, Usmani SZ, Berdeja JG, et al. Updated results from CARTITUDE-1: Phase 1b/2 study of ciltacabtagene autoleucel, a B-cell maturation antigen-directed chimeric antigen receptor T cell therapy, in patients with relapsed/refractory multiple myeloma. Abstract 549. In: 63rd ASH Annual Meeting & Exposition. 2021.
19.
Metadaten
Titel
CAR-T cells—Real-time experience applying CAR-T cells—What we have learned so far
verfasst von
Univ.-Prof. Dr. Hildegard Greinix
Publikationsdatum
01.09.2022
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 3/2022
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-022-00830-9