Botulinum toxin A and soft tissue fillers are cornerstones of facial rejuvenation procedures. They can also be of benefit in facial rehabilitation. We report on three female patients who were treated with botulinum toxin A and/or hyaluronic acid-based fillers, one after orthognathic surgery, two after Bell’s palsy, to correct facial asymmetries and loss of volume to restore facial attractiveness and improve their self-esteem and quality of life. These minimally invasive procedures are safe and effective. However, they need to be repeated for the long-term rehabilitation.