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Erschienen in: Wiener Medizinische Wochenschrift 1-2/2015

01.01.2015 | editorial

Biologicals and how they revolutionized rheumatology

verfasst von: Johannes Grisar, MD

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 1-2/2015

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Excerpt

About one and a half decades ago, biological therapies have started to challenge our therapeutic options in rheumatology. Until the late 1990s, the rheumatologist’s armamentarium consisted mainly of methotrexate and other disease-modifying drugs (DMARDs) like sulfasalazine, d-penicillamine, gold and cyclosporine as well as medium to high doses of glucocorticoids and non-steroidal anti-rheumatic drugs (NSAIDs). Although many patients could be treated sufficiently, a noteworthy proportion of them still suffered from rapidly progressing disease despite receiving conventional immunosuppressive drugs. Moreover, these patients often developed several side effects due to the high-dose glucocorticoid and NSAID intake associated with increased morbidity and mortality. …
Literatur
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Zurück zum Zitat Smolen J, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov. 2003;2:473–88.CrossRefPubMed Smolen J, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov. 2003;2:473–88.CrossRefPubMed
Metadaten
Titel
Biologicals and how they revolutionized rheumatology
verfasst von
Johannes Grisar, MD
Publikationsdatum
01.01.2015
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 1-2/2015
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-015-0343-z

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