Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Wiener klinische Wochenschrift 5-6/2013

01.03.2013 | original article

Autologous stem cell transplantation in adults with metastatic sarcoma of the Ewing family: a single centre experience

verfasst von: Wolfgang Lamm, Werner Rabitsch, Wolfgang J. Köstler, Peter Kalhs, Philipp Ubl, MD Thomas Brodowicz

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2013

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Background

Adults with metastatic Ewing family sarcomas (ES) after being treated with standard therapy for localised disease have limited treatment options with curative intent. The aim of this retrospective single centre study was to evaluate the efficacy of autologous stem cell transplantation (ASCT) in this patient population.

Methods

We report on seven consecutive patients with ES. Four patients with initial localised disease developed distant metastases after being treated with initial standard pre-operative chemotherapy followed by surgery and subsequent standard post-operative chemotherapy. Three patients with initial metastatic disease were pre-treated with standard polychemotherapy. All patients received high-dose chemotherapy (HDCT) followed by ASCT for metastatic disease.

Results

For patients with initial metastatic disease, partial remission (PR) was achieved in three patients prior to HDCT. Type of response subsequent to ASCT was complete response (CR) in four patientswith initial localised disease and CR in two patients with initial metastatic disease. No patient died within the first 100 days after HDCT. Side effects were rare and manageable.

Conclusion

This retrospective analysis suggests that ASCT may be considered in patients with metastatic ES, previously treated with standard therapy.
Literatur
1.
Zurück zum Zitat Ginsberg JP, Woo SY, Johnson Me, Hicks MJ, Horowitz ME. Ewing’s sarcoma family of tumors: Ewing’s sarcoma of bone soft tissue and the peripheral primitive neuroectodermal tumors. In: Pizzo PA and Popalack DG editors. Principals and practices of pediatric oncology. Phiadelphia: Lippincott Williams and Wilkins; 2002. pp. 973–1016. Ginsberg JP, Woo SY, Johnson Me, Hicks MJ, Horowitz ME. Ewing’s sarcoma family of tumors: Ewing’s sarcoma of bone soft tissue and the peripheral primitive neuroectodermal tumors. In: Pizzo PA and Popalack DG editors. Principals and practices of pediatric oncology. Phiadelphia: Lippincott Williams and Wilkins; 2002. pp. 973–1016.
2.
Zurück zum Zitat Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 1992;10(359):162–5. CrossRef Delattre O, Zucman J, Plougastel B, et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature. 1992;10(359):162–5. CrossRef
3.
Zurück zum Zitat Dockhorn-Dworniczak B, Schäfer KL, Dantcheva R, et al. Molecular genetic detection of t(11;22)(q24;12) translocation in Ewing sarcoma and malignant peripheral neuroectodermal tumors. Pathologe. 1994;15:103–12. PubMedCrossRef Dockhorn-Dworniczak B, Schäfer KL, Dantcheva R, et al. Molecular genetic detection of t(11;22)(q24;12) translocation in Ewing sarcoma and malignant peripheral neuroectodermal tumors. Pathologe. 1994;15:103–12. PubMedCrossRef
4.
Zurück zum Zitat Paulussen M, Ahrens S, Craft AW, et al. Ewing’s tumors with primary lung metastasis: survival analysis of 114 (European Intergroup) Cooperative Ewing’s Sarcoma Studies patients. J Clin Oncol. 1998;16 :3044–52. PubMed Paulussen M, Ahrens S, Craft AW, et al. Ewing’s tumors with primary lung metastasis: survival analysis of 114 (European Intergroup) Cooperative Ewing’s Sarcoma Studies patients. J Clin Oncol. 1998;16 :3044–52. PubMed
5.
Zurück zum Zitat Cangir A, Vietti TJ, Gehan EA, et al. Ewing’s sarcoma metastatic at diagnosis. Results and comparison of two intergroup Ewing’s sarcoma studies. Cancer. 1990;66 :887–93. PubMedCrossRef Cangir A, Vietti TJ, Gehan EA, et al. Ewing’s sarcoma metastatic at diagnosis. Results and comparison of two intergroup Ewing’s sarcoma studies. Cancer. 1990;66 :887–93. PubMedCrossRef
6.
Zurück zum Zitat Shankar AG, Ashley S, Craft AW, Pinkerton CR. Outcome after relapse an unselected cohort of children and adolescents with Ewing sarcoma. Med Pediatr Oncol. 2003;40:141–7. PubMedCrossRef Shankar AG, Ashley S, Craft AW, Pinkerton CR. Outcome after relapse an unselected cohort of children and adolescents with Ewing sarcoma. Med Pediatr Oncol. 2003;40:141–7. PubMedCrossRef
7.
Zurück zum Zitat Burdach S, van Kaick B, Laws HJ, et al. Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors. An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Düsseldorf University Medical Center, Germany and St. Anna Kinderspital, Vienna, Austria. Ann Oncol. 2000;11:1451–62 (Review). PubMedCrossRef Burdach S, van Kaick B, Laws HJ, et al. Allogeneic and autologous stem-cell transplantation in advanced Ewing tumors. An update after long-term follow-up from two centers of the European Intergroup study EICESS. Stem-Cell Transplant Programs at Düsseldorf University Medical Center, Germany and St. Anna Kinderspital, Vienna, Austria. Ann Oncol. 2000;11:1451–62 (Review). PubMedCrossRef
8.
Zurück zum Zitat Gardner SL, Carreras J, Boudreau C, et al. Myeloablative therapy with autologous stem cell rescue for patients with Ewing sarcoma. Bone Marrow Transplant. 2008;41:867–72 (Epub 2008 Feb 4). PubMedCrossRef Gardner SL, Carreras J, Boudreau C, et al. Myeloablative therapy with autologous stem cell rescue for patients with Ewing sarcoma. Bone Marrow Transplant. 2008;41:867–72 (Epub 2008 Feb 4). PubMedCrossRef
9.
Zurück zum Zitat Rosenthal J, Bolotin E, Shakhnovits M, et al. High-dose therapy with hematopoietic stem cell rescue in patients with poor prognosis Ewing family tumors. Bone Marrow Transplant. 2008;42:311–8 (Epub 2008 Jun 30). PubMedCrossRef Rosenthal J, Bolotin E, Shakhnovits M, et al. High-dose therapy with hematopoietic stem cell rescue in patients with poor prognosis Ewing family tumors. Bone Marrow Transplant. 2008;42:311–8 (Epub 2008 Jun 30). PubMedCrossRef
10.
Zurück zum Zitat Laurence V, Pierga JY, Barthier S, et al. Long-term follow up of high-dose chemotherapy with autologous stem cell rescue in adults with Ewing tumor. Am J Clin Oncol. 2005;28:301–9. PubMedCrossRef Laurence V, Pierga JY, Barthier S, et al. Long-term follow up of high-dose chemotherapy with autologous stem cell rescue in adults with Ewing tumor. Am J Clin Oncol. 2005;28:301–9. PubMedCrossRef
11.
Zurück zum Zitat Engelhardt M, Zeiser R, Ihorst F, Finke J, Müller CI. High-dose chemotherapy and autologous peripheral blood stem cell transplantation in adult patients with high-risk or advanced Ewing and soft tissue sarcoma. J Cancer Res Clin Oncol. 2007;133:1–11. PubMedCrossRef Engelhardt M, Zeiser R, Ihorst F, Finke J, Müller CI. High-dose chemotherapy and autologous peripheral blood stem cell transplantation in adult patients with high-risk or advanced Ewing and soft tissue sarcoma. J Cancer Res Clin Oncol. 2007;133:1–11. PubMedCrossRef
12.
Zurück zum Zitat Lashkari A, Chow WA, Valdes F, et al. Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma. Anticancer Res. 2009;29:3281–8. PubMed Lashkari A, Chow WA, Valdes F, et al. Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma. Anticancer Res. 2009;29:3281–8. PubMed
13.
Zurück zum Zitat Winston DJ, Gale RP. Prevention and treatment of cytomegalovirus Infection and disease after bone marrow transplantation in the 1990s. Bone Marrow Transplant. 1991;8:7–11. PubMed Winston DJ, Gale RP. Prevention and treatment of cytomegalovirus Infection and disease after bone marrow transplantation in the 1990s. Bone Marrow Transplant. 1991;8:7–11. PubMed
14.
Zurück zum Zitat Salzer-Kuntschik M, Brand G, Delling G. Determination of the degree of morphological regression following chemotherapy in malignant bone tumors . Pathologe. 1983;4:135–41. PubMed Salzer-Kuntschik M, Brand G, Delling G. Determination of the degree of morphological regression following chemotherapy in malignant bone tumors . Pathologe. 1983;4:135–41. PubMed
15.
Zurück zum Zitat Kasper B, Lehnert T, Bernd L, et al. High dose chemotherapy with autologous peripheral blood stem cell transplantation for bone and soft-tissue sarcomas. Bone Marrow Transplant. 2004;34:37–41. PubMedCrossRef Kasper B, Lehnert T, Bernd L, et al. High dose chemotherapy with autologous peripheral blood stem cell transplantation for bone and soft-tissue sarcomas. Bone Marrow Transplant. 2004;34:37–41. PubMedCrossRef
Metadaten
Titel
Autologous stem cell transplantation in adults with metastatic sarcoma of the Ewing family: a single centre experience
verfasst von
Wolfgang Lamm
Werner Rabitsch
Wolfgang J. Köstler
Peter Kalhs
Philipp Ubl
MD Thomas Brodowicz
Publikationsdatum
01.03.2013
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 5-6/2013
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-013-0328-0