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01.08.2016 | case report | Ausgabe 15-16/2016 Open Access

Wiener klinische Wochenschrift 15-16/2016

Association of cytomegalovirus infection with hypertension risk: a meta-analysis

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 15-16/2016
Autoren:
Jing Hui, Yuan-yuan Qu, Na Tang, Yong-min Liu, Hua Zhong, La-mei Wang, Qian Feng, Zhen Li, Fang He
Wichtige Hinweise
Jing Hui and Yuan-yuan Qu contribute equally to this work.

Summary

Background

Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail.

Methods

We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI).

Results

Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95–2.05, P = 0.017). There was significant heterogeneity among the studies included (I2 = 70.5 %). The funnel plot and Egger’s test also indicated no publication bias.

Conclusions

The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.
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