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01.08.2016 | case report | Ausgabe 15-16/2016 Open Access

Wiener klinische Wochenschrift 15-16/2016

Association of cytomegalovirus infection with hypertension risk: a meta-analysis

Wiener klinische Wochenschrift > Ausgabe 15-16/2016
Jing Hui, Yuan-yuan Qu, Na Tang, Yong-min Liu, Hua Zhong, La-mei Wang, Qian Feng, Zhen Li, Fang He
Wichtige Hinweise
Jing Hui and Yuan-yuan Qu contribute equally to this work.



Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail.


We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI).


Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95–2.05, P = 0.017). There was significant heterogeneity among the studies included (I2 = 70.5 %). The funnel plot and Egger’s test also indicated no publication bias.


The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.

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