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01.11.2012 | original article | Ausgabe 21-22/2012

Wiener klinische Wochenschrift 21-22/2012

Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 21-22/2012
Autoren:
Miao Haijun, Zhou Xiaohui, Mao Ting, Wilfried Renner, Palida Abulizi, Tang Baopeng

Summary

Background

The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients.

Methods

KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP.

Results

In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192–2.240, p = 0.002).

Conclusion

The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.

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