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Erschienen in: Wiener klinische Wochenschrift 19-20/2017

03.08.2017 | original article

Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations

verfasst von: Na Tang, Jia-Wei Li, Yong-Min Liu, Hua Zhong, La-Mei Wang, Feng-Mei Deng, Jing Hui, Yuan-Yuan Qu, Fang He

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 19-20/2017

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Summary

Background

Human cytomegalovirus (CMV) has been linked to the pathogenesis of elevated arterial blood pressure (BP). Our study aimed to determine the association between anti-CMV titers and arterial BP in the Kazakh and Han Chinese populations.

Material and methods

Kazakh and Han (n = 800 each) (age, ≥18 years) subjects from Xinjiang, China were examined for anti-CMV immunoglobulin (Ig)G titers using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The highest anti-CMV titer tertiles determined within gender and ethnicity groups were compared against the two lower tertiles and seronegative samples.

Results

Multivariate linear regression analysis revealed that anti-CMV titers were independent determinants for elevated systolic (p = 0.006) BP in Kazakh women and inversely associated with systolic (p = 0.004) and mean arterial (p = 0.019) BP in Han women.

Conclusion

The association between CMV infection and/or resulting immune response and BP elevation differed by sex and ethnicity. In Kazakh women, they were associated with elevated BP and the opposite was true among Han women.
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Metadaten
Titel
Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations
verfasst von
Na Tang
Jia-Wei Li
Yong-Min Liu
Hua Zhong
La-Mei Wang
Feng-Mei Deng
Jing Hui
Yuan-Yuan Qu
Fang He
Publikationsdatum
03.08.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 19-20/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1239-2

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