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03.08.2017 | original article | Ausgabe 19-20/2017

Wiener klinische Wochenschrift 19-20/2017

Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 19-20/2017
Autoren:
Na Tang, Jia-Wei Li, Yong-Min Liu, Hua Zhong, La-Mei Wang, Feng-Mei Deng, Jing Hui, Yuan-Yuan Qu, Fang He
Wichtige Hinweise
Na Tang and Jia-Wei Li contributed equally to this work.

Summary

Background

Human cytomegalovirus (CMV) has been linked to the pathogenesis of elevated arterial blood pressure (BP). Our study aimed to determine the association between anti-CMV titers and arterial BP in the Kazakh and Han Chinese populations.

Material and methods

Kazakh and Han (n = 800 each) (age, ≥18 years) subjects from Xinjiang, China were examined for anti-CMV immunoglobulin (Ig)G titers using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The highest anti-CMV titer tertiles determined within gender and ethnicity groups were compared against the two lower tertiles and seronegative samples.

Results

Multivariate linear regression analysis revealed that anti-CMV titers were independent determinants for elevated systolic (p = 0.006) BP in Kazakh women and inversely associated with systolic (p = 0.004) and mean arterial (p = 0.019) BP in Han women.

Conclusion

The association between CMV infection and/or resulting immune response and BP elevation differed by sex and ethnicity. In Kazakh women, they were associated with elevated BP and the opposite was true among Han women.

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