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Erschienen in: Wiener Medizinische Wochenschrift 11-12/2015

01.06.2015 | main topic

Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines

verfasst von: Christian Busch, MD, Seema Noor, PhD, Christian Leischner, Markus Burkard, PhD, Ulrich M. Lauer, MD, Dr. med. Dr. rer. nat. Sascha Venturelli, MD, PhD

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 11-12/2015

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Summary

Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. Based on these findings 6-PN and 8-PN are currently further clinically evaluated in detail.
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Metadaten
Titel
Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines
verfasst von
Christian Busch, MD
Seema Noor, PhD
Christian Leischner
Markus Burkard, PhD
Ulrich M. Lauer, MD
Dr. med. Dr. rer. nat. Sascha Venturelli, MD, PhD
Publikationsdatum
01.06.2015
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 11-12/2015
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-015-0355-8

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