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01.06.2017 | review

American Society of Hematology 2016 annual meeting

Novel strategies in the management of lymphoma

verfasst von: Daniel Heintel, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2017

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Summary

At the last meeting of the American Society of Hematology (ASH), data on first-line treatment with obinutuzumab in indolent lymphoma, as well as promising data on the long-term observation of chronic lymphocytic leukemia (CLL) patients treated with ibrutinib, were presented.

In diffuse large B‑cell lymphoma (DLBCL), again, a more intensified treatment approach failed to improve patient survival. Moreover, and in contrast to indolent lymphoma, the use of obinutuzumab instead of rituximab (R) did not prove to be superior in DLBCL. However, data on lenalidomide maintenance, as well as data on novel agents in primary central nervous system lymphoma (PCNL), were presented. A survival benefit for R maintenance therapy could be shown in mantle cell lymphoma (MCL).

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Nächster Artikel American Society of Hematology 2016 annual meeting

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11.

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Fink. et al. Lenalidomide maintenance after front line therapy substantially prolongs progression free survival in high risk CLL: interim results of a phase 3 study (CLL M1 study of the German CLL study group). 58th ASH Annual Meeting & Exposition. 2016, p abstract 229. oral presentation.

13.

Foa. et al. Results of the phase 3 study of Lenalidomide versus placebo as maintenance therapy following second-line treatment for patients with chronic lymphocytic leukemia (the CONTINUUM trial). 58th ASH Annual Meeting & Exposition. 2016, p abstract 230. oral presentation.

14.

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17.

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18.

Neelapu SS. et al. LBA-6 Kte-C19 (anti-CD19 CAR T cells) induces complete remissions in patients with refractory diffuse large B‑cell Lymphoma (DLBCL): results from the pivotal phase 2 ZUMA-1. 58th ASH Annual Meeting & Exposition. 2016, p abstract LBA-6. oral presentation.

19.

Choquet S. et al. Ibrutinib monotherapy in relapse or refractory primary CNS lymphoma (PCNSL) and primary vitreo-retinal lymphoma (PVRL). Result of the interim analysis of the iLOC phase II study from the Lysa and the French LOC network. 58th ASH Annual Meeting & Exposition. 2016, p abstract 784. oral presentation.

20.

Grommes Ch. et al. Single-agent ibrutinib in recurrent/refractory central nervous system lymphoma. 58th ASH Annual Meeting & Exposition. 2016, p abstract 783. oral presentation.

21.

Ghesquieres H. et al. Rituximab-Lenalidomide (REVRI) in relapse or refractory primary central nervous system (PCNSL) or vitreo retinal lymphoma (PVRL): results of a “proof of concept” phase II study of the French LOC network. 58th ASH Annual Meeting & Exposition. 2016, p abstract 784. oral presentation.

22.

Le Gouill S. et al. Rituximab maintenance after autologous stem cell transplantation prolongs survival in younger patients with mantle cell lymphoma: final results of the randomized phase 3 lyma trial of the Lysa/Goelams group. 58th ASH Annual Meeting & Exposition. 2016, p abstract 145. oral presentation.

Titel: American Society of Hematology 2016 annual meeting
Novel strategies in the management of lymphoma
verfasst von: Daniel Heintel, MD
Publikationsdatum: 01.06.2017
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 2/2017
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-017-0340-6

Springer Medizin Österreich

Summary

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