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Erschienen in: Wiener klinische Wochenschrift 21-22/2021

03.06.2021 | original article

A1B and BB blood group genotypes are risk factors for pulmonary embolism

verfasst von: Tatjana Kereš, Irena Jukić, Tomo Svaguša, Ingrid Prkačin, Jasna Bingulac-Popović, Matea Vinković, Ana Hećimović, Marcela Živković, Nikolina Parašilovac

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2021

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Summary

Background

Pulmonary embolism (PE) is a potentially life-threatening condition that mainly affects the people of advanced age. While certain blood group phenotypes (non‑O blood group) are known risk factors for the development of venous thromboembolism (VTE), there is no research which investigated the association of blood group genotypes with severity of PE. The aim of this study was to investigate the frequency of ABO blood group genotypes among the population of patients with PE and to investigate the correlation of the pulmonary embolism severity index (PESI) score to specific ABO blood group genotypes.

Material and methods

In this cross-sectional study 74 patients with PE diagnosed using CT pulmonary angiography were included and 303 blood donors without VTE or congenital thrombophilia participated as a control group. After isolation of genomic DNA ABO blood group genotype was determined using the polymerase chain reaction sequence-specific amplification (PCR-SSP) method.

Results

We observed a significantly higher frequency of A1B and BB genotypes in patients with PE compared to healthy individuals (A1B 14.9% vs. 4.3%, P < 0.001; BB 5.4% vs. 0.7%, P = 0.004), while the O1O1 genotype was significantly less frequent in patients (24.3% vs. 37.3%, P = 0.036). Analyzing the severity of the clinical presentation according to the PESI score, we did not find a correlation between the severity of the clinical presentation and a certain blood type genotype.

Conclusion

Patients with A1B and BB blood type genotype were at increased risk for developing pulmonary embolism, while patients with O1O1 genotype had a significantly lower risk of developing PE.

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Literatur
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Zurück zum Zitat Jukić I, Bingulac-Popović J, Samaržija M, Lampalo M, Hećimović A, Đogić V, et al. Distribution of main alleles of the ABO system of blood groups in the Croatian population. Acta Medica Croat. 2017;71(4):235–40. Jukić I, Bingulac-Popović J, Samaržija M, Lampalo M, Hećimović A, Đogić V, et al. Distribution of main alleles of the ABO system of blood groups in the Croatian population. Acta Medica Croat. 2017;71(4):235–40.
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Metadaten
Titel
A1B and BB blood group genotypes are risk factors for pulmonary embolism
verfasst von
Tatjana Kereš
Irena Jukić
Tomo Svaguša
Ingrid Prkačin
Jasna Bingulac-Popović
Matea Vinković
Ana Hećimović
Marcela Živković
Nikolina Parašilovac
Publikationsdatum
03.06.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01882-3