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Erschienen in: Wiener klinische Wochenschrift 23-24/2014

01.12.2014 | case report

A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment

verfasst von: Suna Yapali, MD, Assist. Prof. Ilker Turan, Prof. Omer Ozutemiz, Prof. Oktay Tekesin

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 23-24/2014

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Summary

D-penicillamine has long been used in the management of rheumatic diseases due to the effects on inhibition of collagen synthesis. Herein, we report a severe case of esophageal ulcer causing a tight stricture extending through the distal esophagus despite the long-term D-penicillamine treatment in a patient with Wilson’s disease. D-penicillamine would theoretically be expected to contribute to the healing of an esophageal ulcer. However, the drug failed to have a favorable outcome, which is notable and worth reporting.
Literatur
1.
Zurück zum Zitat Ruigomez A, Garcia Rodriguez LA, Wallander MA, Johansson S, Eklund S. Esophageal stricture: incidence, treatment patterns, and recurrence rate. Am J Gastroenterol. 2006;101(12):2685–92.PubMed Ruigomez A, Garcia Rodriguez LA, Wallander MA, Johansson S, Eklund S. Esophageal stricture: incidence, treatment patterns, and recurrence rate. Am J Gastroenterol. 2006;101(12):2685–92.PubMed
2.
Zurück zum Zitat Wienbeck M, Barnert J. Epidemiology of reflux disease and reflux esophagitis. Scand J Gastroenterol Suppl. 1989;156:7–13.PubMedCrossRef Wienbeck M, Barnert J. Epidemiology of reflux disease and reflux esophagitis. Scand J Gastroenterol Suppl. 1989;156:7–13.PubMedCrossRef
3.
4.
Zurück zum Zitat Higuchi D, Sugawa C, Shah SH, Tokioka S, Lucas CE. Etiology, treatment, and outcome of esophageal ulcers: a 10-year experience in an urban emergency hospital. J Gastrointest Surg. 2003;7(7):836–42.PubMedCrossRef Higuchi D, Sugawa C, Shah SH, Tokioka S, Lucas CE. Etiology, treatment, and outcome of esophageal ulcers: a 10-year experience in an urban emergency hospital. J Gastrointest Surg. 2003;7(7):836–42.PubMedCrossRef
5.
Zurück zum Zitat Kikendall JW. Pill-induced esophageal injury. Gastroenterol Clin North Am. 1991;20(4):835–46.PubMedCrossRef Kikendall JW. Pill-induced esophageal injury. Gastroenterol Clin North Am. 1991;20(4):835–46.PubMedCrossRef
6.
Zurück zum Zitat Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF. Pill-induced esophageal injury. Case reports and review of the medical literature. Dig Dis Sci. 1983;28(2):174–82.CrossRef Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF. Pill-induced esophageal injury. Case reports and review of the medical literature. Dig Dis Sci. 1983;28(2):174–82.CrossRef
7.
Zurück zum Zitat Lipsky PE. Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes. J Clin Invest. 1984;73(1):53–65.PubMedCrossRef Lipsky PE. Immunosuppression by D-penicillamine in vitro. Inhibition of human T lymphocyte proliferation by copper- or ceruloplasmin-dependent generation of hydrogen peroxide and protection by monocytes. J Clin Invest. 1984;73(1):53–65.PubMedCrossRef
8.
Zurück zum Zitat Siegel RC. Collagen cross-linking. Effect of D-penicillamine on cross-linking in vitro. J Biol Chem. 1977;252(1):254–9.PubMed Siegel RC. Collagen cross-linking. Effect of D-penicillamine on cross-linking in vitro. J Biol Chem. 1977;252(1):254–9.PubMed
9.
Zurück zum Zitat Nikeghbalian S, Atefi S, Kazemi K, Roshan N, Tanideh N, Jalaeian H. Effect of oral D- penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats. Fertil Steril. 2007;88(4 Suppl):1187–9.PubMedCentralPubMedCrossRef Nikeghbalian S, Atefi S, Kazemi K, Roshan N, Tanideh N, Jalaeian H. Effect of oral D- penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats. Fertil Steril. 2007;88(4 Suppl):1187–9.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Zhang QY, Ma S, Xi D, Zhang WT, Li AW. Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions. BMC Surg. 2011;11:5.PubMedCrossRef Zhang QY, Ma S, Xi D, Zhang WT, Li AW. Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions. BMC Surg. 2011;11:5.PubMedCrossRef
11.
Zurück zum Zitat Balint GA, Varro V. The effect of D-penicillamine in different experimental gastric ulcer models in the rat. Acta Med Hung. 1985;42(3-4):175–7.PubMedCrossRef Balint GA, Varro V. The effect of D-penicillamine in different experimental gastric ulcer models in the rat. Acta Med Hung. 1985;42(3-4):175–7.PubMedCrossRef
13.
Zurück zum Zitat Atzori L, Pinna AL, Pau M, Aste N. D-penicillamine elastosis perforans serpiginosa: description of two cases and review of the literature. Dermatol Online J. 2011;17(4):3.PubMed Atzori L, Pinna AL, Pau M, Aste N. D-penicillamine elastosis perforans serpiginosa: description of two cases and review of the literature. Dermatol Online J. 2011;17(4):3.PubMed
Metadaten
Titel
A severe case of esophageal ulcer causing a tight stricture despite long-term D-penicillamine treatment
verfasst von
Suna Yapali, MD
Assist. Prof. Ilker Turan
Prof. Omer Ozutemiz
Prof. Oktay Tekesin
Publikationsdatum
01.12.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 23-24/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0610-9

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