Skip to main content


Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.09.2012 | original article | Ausgabe 17-18/2012

Wiener klinische Wochenschrift 17-18/2012

A preliminary study about the effects of warm priming solution on oxidative stress and postoperative atrial fibrillation in open heart surgery

Wiener klinische Wochenschrift > Ausgabe 17-18/2012
MD Asoc. Prof. Mustafa Buyukates, MD Asoc. Prof. Serefden Acikgoz, MD Asoc. Prof. Erol Aktunc, MD Asoc. Prof. Ozer Kandemir, MD Asoc. Prof. Sait Mesut Dogan, MD Prof. Mustafa Aydin



An important reason for production of ischemia and reperfusion injury and oxidative stress is the sudden and rapid changes in body temperature during the institution of cardiopulmonary bypass. The aim of this study was to investigate the effects of warm priming solution on oxidative stress and atrial fibrillation.


This is a preliminary prospective study on a group of 40 patients who underwent elective coronary artery bypass grafting operation using cardiopulmonary bypass. Patients were randomized into two groups, each consisting of 20 patients; one group was primed with a solution at 20 °C and the other at 36 °C initially for cardiopulmonary bypass. Blood samples from both of the groups were drawn preoperatively and at the 15th and 60th min of aortic cross clamping and 24th h following the surgery. Serum malondialdehyde levels, protein carbonyl content and total antioxidant status were detected. Patients were followed for postoperative atrial fibrillation.


Malondialdehyde and protein carbonyl content were found to be significantly higher and total antioxidant status was concordantly lower in the cold priming group at the 15th and 60th min, recovering to the normal range postoperatively at the 24th h. Patients in the cold priming group had developed a significantly higher rate of atrial fibrillation when compared with the patients in the warm priming group during the postoperative period.


In conclusion, although this study has its limitation about the sample size it may provide an insight about the probable preventive effects of 36 °C warm priming solution in oxidative stress and postoperative atrial fibrillation.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:

Abo für kostenpflichtige Inhalte

Über diesen Artikel

Weitere Artikel der Ausgabe 17-18/2012

Wiener klinische Wochenschrift 17-18/2012 Zur Ausgabe