Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Wiener klinische Wochenschrift 1-2/2015

01.01.2015 | review article

10th anniversary of the Austrian MDS Platform: aims and ongoing projects

verfasst von: MD Sonja Burgstaller, Peter Bettelheim, Otto Krieger, Sigrid Machherndl-Spandl, Thomas Nösslinger, Lisa Pleyer, Heinz Sill, Wolfgang R. Sperr, Reinhard Stauder, Peter Valent, Michael Pfeilstöcker

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2015

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

The Austrian myelodysplastic syndromes (MDS) Platform was founded as a national working group in 2003 to initiate and coordinate common projects in the field. The incidence of MDS in Austria is approximately 400–500 new MDS cases per year. The overall low number of MDS patients underlines the importance of a national initiative to concentrate knowledge at certain specialized centres, where treatment of these patients mainly takes place. Clinical trials as well as basic research are facilitated by the cooperation of university and non-university hospitals. Other objectives are the generation of therapeutic standards, organization of meetings to spread this information to physicians and patients as well as promoting patient-support groups. Cooperation with international working groups is another important aim of the Platform. The 10th anniversary of the Austrian MDS Platform was organized as a meeting for all interested physicians throughout Austria providing an update on the disease and ongoing projects.
Literatur
1.
Zurück zum Zitat Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189–99. CrossRef Bennet JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189–99. CrossRef
2.
Zurück zum Zitat Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114:937–51. PubMedCrossRef Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114:937–51. PubMedCrossRef
3.
Zurück zum Zitat Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A. Therapy-related myeloid neoplasms: pathobiology and clinical characteristics. Br J Pharmacol. 2011;162:792–805. PubMedCentralPubMedCrossRef Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A. Therapy-related myeloid neoplasms: pathobiology and clinical characteristics. Br J Pharmacol. 2011;162:792–805. PubMedCentralPubMedCrossRef
4.
Zurück zum Zitat Valent P, Horny HP, Bennet JM, Fonatsch C, Germing U, Greenberg P, et al. Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: consensus statements and report from a working conference. Leuk Res. 2007;31:727–36. PubMedCrossRef Valent P, Horny HP, Bennet JM, Fonatsch C, Germing U, Greenberg P, et al. Definitions and standards in the diagnosis and treatment of the myelodysplastic syndromes: consensus statements and report from a working conference. Leuk Res. 2007;31:727–36. PubMedCrossRef
5.
Zurück zum Zitat Westers TM, Ireland R, Kern W, Alhan C, Balleisen JS, Bettelheim P, et al. Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group. Leukemia. 2012;26:1730–41. PubMedCrossRef Westers TM, Ireland R, Kern W, Alhan C, Balleisen JS, Bettelheim P, et al. Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group. Leukemia. 2012;26:1730–41. PubMedCrossRef
6.
Zurück zum Zitat Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz M, et al. International scoring system for evaluating prognosis in myelodysplastic sydromes. Blood. 1997;89:2079–88. PubMed Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz M, et al. International scoring system for evaluating prognosis in myelodysplastic sydromes. Blood. 1997;89:2079–88. PubMed
7.
Zurück zum Zitat Greenberg P, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120:2454–65. PubMedCrossRef Greenberg P, Tuechler H, Schanz J, Sanz G, Garcia-Manero G, Solé F, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood. 2012;120:2454–65. PubMedCrossRef
8.
Zurück zum Zitat Nösslinger T, Tüchler H, Germing U, Sperr WR, Krieger O, Haase D, et al. Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes. Ann Oncol. 2010;21:120–5. PubMedCrossRef Nösslinger T, Tüchler H, Germing U, Sperr WR, Krieger O, Haase D, et al. Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes. Ann Oncol. 2010;21:120–5. PubMedCrossRef
9.
Zurück zum Zitat Stauder R, Nösslinger T, Pfeilstöcker M, Sperr WR, Wimazal F, Krieger O, et al. Impact of age and comorbidity in myelodysplastic syndromes. J Natl Compr Canc Netw. 2008;9:927–34. Stauder R, Nösslinger T, Pfeilstöcker M, Sperr WR, Wimazal F, Krieger O, et al. Impact of age and comorbidity in myelodysplastic syndromes. J Natl Compr Canc Netw. 2008;9:927–34.
10.
Zurück zum Zitat Sperr WR, Wimazal F, Kundi M, Baumgartner C, Nösslinger T, Makrai A, et al. Comorbidity as prognostic variable in MDS: comparative evaluation of the HCT-CI and CCI in a core dataset of 419 patients of the Austrian MDS Study Group. Ann Oncol. 2010;21:114–9. PubMedCrossRef Sperr WR, Wimazal F, Kundi M, Baumgartner C, Nösslinger T, Makrai A, et al. Comorbidity as prognostic variable in MDS: comparative evaluation of the HCT-CI and CCI in a core dataset of 419 patients of the Austrian MDS Study Group. Ann Oncol. 2010;21:114–9. PubMedCrossRef
11.
Zurück zum Zitat Zipperer E, Pelz D, Nachtkamp K, Kuendgen A, Strupp C, Gattermann N, et al. The hematopoietic stem cell transplantation comorbidity index is of prognostic relevance for patients with myelodysplastic syndrome. Haematologica. 2009;94:729–32. PubMedCentralPubMedCrossRef Zipperer E, Pelz D, Nachtkamp K, Kuendgen A, Strupp C, Gattermann N, et al. The hematopoietic stem cell transplantation comorbidity index is of prognostic relevance for patients with myelodysplastic syndrome. Haematologica. 2009;94:729–32. PubMedCentralPubMedCrossRef
12.
Zurück zum Zitat Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83. PubMedCrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–83. PubMedCrossRef
13.
Zurück zum Zitat Sorror ML, Maris MB, Baron F, Sandmaier BM, Maloney DG, Storer B. Hematopoietic Cell Transplantation (HCT)-Specific Comorbidity Index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106:2912–9. PubMedCentralPubMedCrossRef Sorror ML, Maris MB, Baron F, Sandmaier BM, Maloney DG, Storer B. Hematopoietic Cell Transplantation (HCT)-Specific Comorbidity Index: a new tool for risk assessment before allogeneic HCT. Blood. 2005;106:2912–9. PubMedCentralPubMedCrossRef
14.
Zurück zum Zitat Sperr WR, Kundi M, Wimazal F, Nösslinger T, Schönmetzler-Makrai A, Stauder R, et al. Proposed score for survival of patients with myelodysplastic syndromes. Eur J Clin Invest. 2013;43:1120–8. PubMed Sperr WR, Kundi M, Wimazal F, Nösslinger T, Schönmetzler-Makrai A, Stauder R, et al. Proposed score for survival of patients with myelodysplastic syndromes. Eur J Clin Invest. 2013;43:1120–8. PubMed
15.
Zurück zum Zitat Bammer C, Sperr WR, Kemmler G, Wimazal F, Nösslinger T, Schönmetzler A, et al. Clustering of comorbidities is related to age and sex and impacts clinical outcome in myelodysplastic syndromes. J Geriatr Oncol. 1879;4068(14):299–306. doi:10.1016/j.jgo.2014.02.002 Bammer C, Sperr WR, Kemmler G, Wimazal F, Nösslinger T, Schönmetzler A, et al. Clustering of comorbidities is related to age and sex and impacts clinical outcome in myelodysplastic syndromes. J Geriatr Oncol. 1879;4068(14):299–306. doi:10.1016/j.jgo.2014.02.002
16.
Zurück zum Zitat Hamaker ME, Prins MC, Stauder R. The relevance of a geriatric assessment for elderly patients with a haematologic malignancy—a systematic review. Leuk Res. 2014;38:275–83. PubMedCrossRef Hamaker ME, Prins MC, Stauder R. The relevance of a geriatric assessment for elderly patients with a haematologic malignancy—a systematic review. Leuk Res. 2014;38:275–83. PubMedCrossRef
17.
Zurück zum Zitat Stauder R. The challenge of personalized risk assessment and therapy planning in elderly high-risk myelodysplastic syndromes (MDS) patients. Ann Haematol. 2012;91:1333–43. CrossRef Stauder R. The challenge of personalized risk assessment and therapy planning in elderly high-risk myelodysplastic syndromes (MDS) patients. Ann Haematol. 2012;91:1333–43. CrossRef
18.
Zurück zum Zitat Stauder R, Wimazal F, Nösslinger T, Krieger O, Sperr WR, Sill H, et al. Individualized management and therapy of myelodysplastic syndromes. Wien Klin Wochenschr. 2008;120:523–37. PubMedCrossRef Stauder R, Wimazal F, Nösslinger T, Krieger O, Sperr WR, Sill H, et al. Individualized management and therapy of myelodysplastic syndromes. Wien Klin Wochenschr. 2008;120:523–37. PubMedCrossRef
19.
Zurück zum Zitat Greenberg PL, Sun Z, Miller KB, Bennett JM, Tallman MS, Dewald G, et al. Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996). Blood. 2009;114:2393–400. PubMedCentralPubMedCrossRef Greenberg PL, Sun Z, Miller KB, Bennett JM, Tallman MS, Dewald G, et al. Treatment of myelodysplastic syndrome patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase 3 trial by the Eastern Cooperative Oncology Group (E1996). Blood. 2009;114:2393–400. PubMedCentralPubMedCrossRef
20.
Zurück zum Zitat Hellstrom-Lindberg E, Gulbrandsen N, Lindberg G, Ahlgren T, Dahl IM, Dybedal I, et al. Scandinavian MDS group. A validated decision model for treating the anaemia of myelodysplatic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life. Br J Haematol. 2003;120:1037–46. PubMedCrossRef Hellstrom-Lindberg E, Gulbrandsen N, Lindberg G, Ahlgren T, Dahl IM, Dybedal I, et al. Scandinavian MDS group. A validated decision model for treating the anaemia of myelodysplatic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life. Br J Haematol. 2003;120:1037–46. PubMedCrossRef
21.
Zurück zum Zitat Valent P, Krieger O, Stauder R, Wimazal F, Nösslinger T, Sperr WR, et al. Iron overload in myelodysplastic syndromes (MDS)—diagnosis, management, and response criteria: a proposal of the Austrian MDS Platform. Eur J Clin Invest. 2008;38:143–9. PubMedCentralPubMedCrossRef Valent P, Krieger O, Stauder R, Wimazal F, Nösslinger T, Sperr WR, et al. Iron overload in myelodysplastic syndromes (MDS)—diagnosis, management, and response criteria: a proposal of the Austrian MDS Platform. Eur J Clin Invest. 2008;38:143–9. PubMedCentralPubMedCrossRef
22.
Zurück zum Zitat Haase D, Germing U, Schanz J, Pfeilstöcker M, Nösslinger T, Hildebrandt B, et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood. 2007;110:4385–95. PubMedCrossRef Haase D, Germing U, Schanz J, Pfeilstöcker M, Nösslinger T, Hildebrandt B, et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood. 2007;110:4385–95. PubMedCrossRef
23.
Zurück zum Zitat Fenaux P, Giagounidis A, Sellelag D, Beyne-Rauzy O, Mufti G, Mittelman M, et al. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with low-/intermediate-1-risk myelodysplastic syndromes with del5q. Blood. 2011;118:3765–76. PubMedCrossRef Fenaux P, Giagounidis A, Sellelag D, Beyne-Rauzy O, Mufti G, Mittelman M, et al. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with low-/intermediate-1-risk myelodysplastic syndromes with del5q. Blood. 2011;118:3765–76. PubMedCrossRef
24.
Zurück zum Zitat List A, Dewald G, Bennet J, Giagounidis A, Raza A, Feldman E, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med. 2006;355:456–65. CrossRef List A, Dewald G, Bennet J, Giagounidis A, Raza A, Feldman E, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med. 2006;355:456–65. CrossRef
25.
Zurück zum Zitat Cutler CS, Lee SJ, Greenberg P, Deeg HJ, Pérez WS, Anasetti C, et al. A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome. Blood. 2004;104:579–85. PubMedCrossRef Cutler CS, Lee SJ, Greenberg P, Deeg HJ, Pérez WS, Anasetti C, et al. A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome. Blood. 2004;104:579–85. PubMedCrossRef
26.
Zurück zum Zitat Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher risk myelodysplastic syndromes: a randomised, open-label phase III study. Lancet Oncol. 2009;10:223–32. PubMedCentralPubMedCrossRef Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher risk myelodysplastic syndromes: a randomised, open-label phase III study. Lancet Oncol. 2009;10:223–32. PubMedCentralPubMedCrossRef
27.
Zurück zum Zitat Prébet T, Gore DS, Esterni B, Gardin C, Itzykson R, Thepot S, et al. Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol. 2011;29:475–83. CrossRef Prébet T, Gore DS, Esterni B, Gardin C, Itzykson R, Thepot S, et al. Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure. J Clin Oncol. 2011;29:475–83. CrossRef
28.
Zurück zum Zitat Pleyer L, Stauder R, Thaler J, Ludwig H, Pfeilstöcker M, Steinkirchner S, et al. Overall survival data of patients with MDS, AML and CMML from the Austrian Azacitidine Registry of 184 consecutive patients. Leuk Res. 2011;35(Suppl 1):450. Pleyer L, Stauder R, Thaler J, Ludwig H, Pfeilstöcker M, Steinkirchner S, et al. Overall survival data of patients with MDS, AML and CMML from the Austrian Azacitidine Registry of 184 consecutive patients. Leuk Res. 2011;35(Suppl 1):450.
29.
Zurück zum Zitat Pleyer L, Germing U, Sperr WR, Linkesch W, Burgstaller S, Stauder R, et al. Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival. Leuk Res. 2014;38:475–83. PubMedCrossRef Pleyer L, Germing U, Sperr WR, Linkesch W, Burgstaller S, Stauder R, et al. Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival. Leuk Res. 2014;38:475–83. PubMedCrossRef
Metadaten
Titel
10th anniversary of the Austrian MDS Platform: aims and ongoing projects
verfasst von
MD Sonja Burgstaller
Peter Bettelheim
Otto Krieger
Sigrid Machherndl-Spandl
Thomas Nösslinger
Lisa Pleyer
Heinz Sill
Wolfgang R. Sperr
Reinhard Stauder
Peter Valent
Michael Pfeilstöcker
Publikationsdatum
01.01.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0627-0