Substituting Carbamazepine with Oxcarbazepine Increases Citalopram Levels. A Report on Two Cases

E. Leinonen; U. Lepola; H. Koponen

doi:10.1055/s-2007-979563

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Pharmacopsychiatry 1996; 29(4): 156-158
DOI: 10.1055/s-2007-979563

Case Report

Substituting Carbamazepine with Oxcarbazepine Increases Citalopram Levels. A Report on Two Cases

E. Leinonen¹ , U. Lepola² , H. Koponen³

¹Department of Psychiatry, University of Oulu, Oulu, Finland
²Senior Lecturer, Kuopio Psychiatric Research Clinic, Kuopio, Finland
³Senior Lecturer, Moisio Hospital, Mikkeli, Finland

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Publication Date:
23 April 2007 (online)

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The combination of antiepileptic and psychotropic medications is not uncommon. The widely used anticonvulsant carbamazepine, however, has been found to induce the degradation of many psychiatric drugs. On the contrary, its 10-keto analog oxcarbazepine does not have a significant effect on the metabolism of concomitant drugs. Consequently, when carbamazepine medication is changed to oxcarbazepine, the serum concentrations of various concurrently used drugs may increase, resulting in alterations in the therapeutic and toxic response. In this paper we describe two patients with comorbid epilepsy, major depression, and panic disorder, whose serum citalopram levels increased and antidepressant response changed when concurrent carbamazepine treatment was substituted with oxcarbazepine.

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