Advances in Clinical and Experimental Medicine

Title abbreviation: Adv Clin Exp Med
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ISSN 1899–5276 (print)
ISSN 2451-2680 (online)
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Advances in Clinical and Experimental Medicine

2014, vol. 23, nr 6, November-December, p. 1011–1017

Publication type: review

Language: English

The Use of Stem Cells in Plastic and Reconstructive Surgery

Maciej Koźlik1,A,B,C,D,F, Piotr Wójcicki1,2,A,C,E,F

1 Department of Plastic Surgery, Wroclaw Medical University, Polanica-Zdrój, Poland

2 Department of Plastic Surgery, Specialist Medical Center, Polanica-Zdrój, Poland

Abstract

As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures.

Key words

stem cells, adult stem cells, plastic surgery.

References (40)

  1. Beck B, Blanpain C: Mechanisms regulating epidermal stem cells. EMBO J 2012, 31, 2067–2075.
  2. Wang Z, Oron E, Nelson B, Razis S, Ivanova N: Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 2012, 10, 440–454.
  3. Rohwedel J, Maltsev V, Bober E: Muscle cell differentiation of embryonic stem cells reflects myogenesis in vivo: developmentally regulated expression of myogenic determination genes and functional expression of ionic currents. Dev Biol 1994, 164, 87.
  4. Maltsev VA, Rohwedel J, Hescheler J, Wobus AM: Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 1993, 44, 41.
  5. Zhu J, Zhang K, Sun Y, Gao X, Li Y, Chen Z, Wu X: Reconstruction of functional ocular surface by acellular porcine cornea matrix scaffold and limbal stem cells derived from human embryonic stem cells. Tissue Eng Part A 2013, 19, 2412–2425.
  6. Leydon C, Selekman JA, Palecek S, Thibeault SL: Human embryonic stem cell-derived epithelial cells in a novel in vitro model of vocal mucosa. Tissue Eng Part A 2013, 19, 2233–2241.
  7. Zarzeczny A, Caulfield T: Emerging ethical, legal and social issues associated with stem cell research and the current role of the moral status of the embryo. Stem Cell Rev 2009, 5, 96–101.
  8. Wakitani S, Takaoka K, Hattori T, Miyazawa N, Iwanaga T, Takeda S, Watanabe TK, Tanigami A: Embryonic stem cells injected into the mouse knee joint form teratomas and subsequently destroy the joint. Rheumatology (Oxford) 2003, 42, 162–165.
  9. da Silva Meirelles L, Caplan AI, Nardi NB: In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008, 26, 2287–2299.
  10. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131, 861–872.
  11. Obokata H, Sasai Y, Niwa H, Kadota M, Andrabi M, Takata N, Tokoro M, Terashita Y, Yonemura S, Vacanti CA, Wakayama T: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature 2014, 505, 676–680.
  12. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K: Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006, 24, 1294–1301.
  13. Cai L, Johnstone BH, Cook TG, Tan J, Fishbein MC, Chen PS, March KL: IFATS collection: Human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells 2009, 27, 230–237.
  14. Torres FC, Rodrigues CJ, Stocchero IN, Ferreira MC: Stem cells from the fat tissue of rabbits: an easy-to-find experimental source. Aesthetic Plast Surg 2007, 31, 574–578.
  15. Tiryaki T, Findikli N, Tiryaki D: Staged stem cell-enriched tissue (SET) injections for soft tissue augmentation in hostile recipient areas: a preliminary report. Aesthetic Plast Surg 2011, 35, 965–971.
  16. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, March KL: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004, 16, 109, 1292–1298.
  17. Kucerova L, Kovacovicova M, Polak S, Bohac M, Fedeles J, Palencar D, Matuskova M: Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells. Neoplasma 2011, 58, 361–370.
  18. Ma Z, Han D, Zhang P, Yang JF, Wang Y, Zhang Y, Yang D, Liu J: Utilizing Muscle-Derived Stem Cells to Enhance Long-Term Retention and Aesthetic Outcome of Autologous Fat Grafting: Pilot Study in Mice. Aesth Plast Surg 2012, 36, 186–192.
  19. Orbay H, Tobita M, Hyakusoku H, Mizuno H: Effects of adipose-derived stem cells on improving the viability of diced cartilage grafts. Plast Reconstr Surg 2012, 129, 369–377.
  20. Schultheiss J, Seebach C, Henrich D, Willhelm K, Barker JH, Frank J: Mesenchymal stem cell (MSC) and endothelial progenitor cell (EPC) growth and adhesion in six different bone graft substitutes. Eur J Trauma Emerg Surg 2011, 37, 635–644.
  21. Hao W, Dong J, Jiang M, Wu J, Cui F, Zhou D: Enhanced bone formation in large segmental radial defects by combining adipose-derived stem cells expressing bone morphogenetic protein 2 with nHA/RHLC/PLA scaffold. Int Orthop 2010, 34, 1341–1349.
  22. Stockmann P, Park J, von Wilmowsky C, Nkenke E, Felszeghy E, Dehner JF, Schmitt C, Tudor C, Schlegel KA: Guided bone regeneration in pig calvarial bone defects using autologous mesenchymal stem/progenitor cells—a comparison of different tissue sources. J Craniomaxillofac Surg 2012, 40, 310–320.
  23. Qi M, Hu J, Zou S, Zhou H, Han L: Mandibular distraction osteogenesis enhanced by bone marrow mesenchymal stem cells in rats. J Craniomaxillofac Surg 2006, 34, 283–289.
  24. Behnia H, Khojasteh A, Soleimani M, Tehranchi A, Atashi A: Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: a preliminary report. J Craniomaxillofac Surg 2012, 40, 2–7.
  25. Smith DM, Cooper GM, Afifi AM, Mooney MP, Cray J, Rubin JP, Marra KG, Losee JE: Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2. Plast Reconstr Surg 2011, 128, 1053–1060.
  26. Glasberg SB, D’Amico R: Use of regenerative human acellular tissue (AlloDerm) to reconstruct the abdominal wall following pedicle TRAM flap breast reconstruction surgery. Plast Reconstr Surg 2006, 118, 8–15.
  27. Orbay H, Takami Y, Hyakusoku H, Mizuno H: Acellular Dermal Matrix Seeded with Adipose-Derived Stem Cells as a Subcutaneous Implant. Aesth Plast Surg 2011, 35, 756–763.
  28. Reichenberger MA, Mueller W, Schafer A: Adipose Derived Stem Cells Protect Skin Flaps Against Ischemia– Reperfusion Injury. Stem Cell Rev Rep 2012, 8, 854–862.
  29. Mesimäki K, Lindroos B, Törnwall J, Mauno J, Lindqvist C, Kontio R, Miettinen S, Suuronen R: Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg 2009, 38, 201–209.
  30. Warnke PH, Springer IN, Wiltfang J, Acil Y, Eufinger H, Wehmöller M, Russo PA, Bolte H, Sherry E, Behrens E, Terheyden H: Growth and transplantation of a custom vascularised bone graft in a man. Lancet 2004, 364, 766–770.
  31. Sándor GK, Tuovinen VJ, Wolff J, Patrikoski M, Jokinen J, Nieminen E, Mannerström B, Lappalainen OP, Seppänen R, Miettinen S: Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration. J Oral Maxillofac Surg 2013, 71, 938–950.
  32. Hanson SE, Bentz ML, Hematti P: Mesenchymal stem cell therapy for nonhealing cutaneous wounds. Plast Reconstr Surg 2010, 125, 510–516.
  33. Wu Y, Chen L, Scott PG, Tredget EE: Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007, 25, 2648–2659.
  34. Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N, Shrayer D, Carson P: Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng 2007, 13, 1299–1312.
  35. Yoshikawa T, Mitsuno H, Nonaka I, Sen Y, Kawanishi K, Inada Y, Takakura Y,Okuchi K, Nonomura A: Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg 2008, 121, 860–877.
  36. Leonardi D, Oberdoerfer D, Fernandes MC, Meurer RT, Pereira-Filho GA, Cruz P, Vargas M, Chem RC, Camassola M, Nardi NB: Mesenchymal stem cells combined with an artificial dermal substitute improve repair in full-thickness skin wounds. Burns 2012, 38, 1143–1150.
  37. Öksüz S, Ülkür E, Öncül O, Köse GT, Küçükodaci Z, Urhan M: The effect of subcutaneous mesenchymal stem cell injection on statis zone and apoptosis in an experimental burn model. Plast Reconstr Surg 2013, 131, 463–471.
  38. Yoshimura K, Asano Y, Aoi N, Kurita M, Oshima Y, Sato K, Inoue K, Suga H, Eto H, Kato H, Harii K: Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications. Breast J 2010, 16, 169–175.
  39. Tanikawa DY, Aguena M, Bueno DF, Passos-Bueno MR, Alonso N: Fat grafts supplemented with adipose-derived stromal cells in the rehabilitation of patients with craniofacial microsomia. Plast Reconstr Surg 2013, 132, 141–152.
  40. Pathomvanich D, Palakurthi R: Application of stem cells in hair restoration surgery. In: Hair restoration Surgery in Asians. Eds.: Pathomvanich D, Imagawa K, Springer, New York 2010, 279–284.
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