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Onkologie 13. Mai 2015

Predicting drug sensitivity by 3D cell culture models

Because of recent failures of novel drugs in phase II and III trials innovative in vitro models are needed that may predict drug efficacy in patients. Although, numerous modifications of traditional cell culture and animal models were undertaken significant improvements in cell culture- based drug development have not been achieved. Three-dimensional (3D) cell culture may represents a modern alternative to bridge the gap between 2D cell cultures and animal models.

Arno Amann, Gabriele Gamerith, Julia M. Huber, Marit Zwierzina, Wolfgang Hilbe, Heinz Zwierzina, memo - Magazine of European Medical Oncology 1/2015

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