Importance of intraoperative radiation therapy in the treatment of soft tissue sarcoma: data at hand
Intraoperative radiation therapy (IORT) delivers a high single-dose radiation during surgery, which in combination with perioperative conventional fractionated external beam radiation therapy enables increase the total dose to the tumor bed without increasing normal tissue morbidity. Therefore, it can improve local tumor control. Numerous clinical studies have proved the feasibility and efficacy of IORT in patients with sarcomas of the trunk and extremities, as well as retroperitoneal tumors. In this publication, theoretical and practical essentials regarding the utilization of IORT in the multimodal treatment of sarcoma will be discussed.