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Erschienen in: memo - Magazine of European Medical Oncology 1/2014

01.02.2014 | editorial

The importance of HPV vaccination today

verfasst von: Reinhard Höpfl, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 1/2014

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Excerpt

In the 1930s, Richard Shope [1] unravelled a mystery about an animal hybrid between “jackrabbits” and “antalops”; these mythical “horned” cottontail rabbits called Jackalops were infected by an oncogenic viral agent. Half a century later, Nobel Prize laureate Harald zur Hausen [2] postulated that certain human papillomaviruses (HPV) cause cervical cancer by sexual transmission. Disappointingly, HPV-6 or -11 detected in genital warts were not found in cancer tissue. Instead, in 1985, weak hybridizing signals cross-reacting with HPV-11 revealed the distantly related high-risk HPV types 16 and 18 to be present in cervical cancer. With support of his staff around Lutz Gissmann and in a worldwide academic concerted action, the mechanisms of HPV-induced carcinogenesis were subsequently elucidated. For example, HPV hampers apoptosis via deregulation of tumor suppressor functions of p53 and retinoblastoma protein, leading to immortalized (not yet malignant) cell lines vulnerable to second steps of transformation. Yet, most HPV infections resolve spontaneously. Thus, HPV testing without a wise concept of management for positive results could lead to unnecessary overtreatment. …
Literatur
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Zurück zum Zitat Kreider JW, et al. Morphologic transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature. 1985;317:639–41.PubMedCrossRef Kreider JW, et al. Morphologic transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature. 1985;317:639–41.PubMedCrossRef
4.
Zurück zum Zitat Zhou J, Sun XY, Stenzel DJ, Frazer IH. Expression of vaccinia recombinant HPV 16 L1 and L2 ORF protein in epithelial cells is sufficient for assembly of HPV virion-like particles. Virology. 1991;185:251–7.PubMedCrossRef Zhou J, Sun XY, Stenzel DJ, Frazer IH. Expression of vaccinia recombinant HPV 16 L1 and L2 ORF protein in epithelial cells is sufficient for assembly of HPV virion-like particles. Virology. 1991;185:251–7.PubMedCrossRef
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Zurück zum Zitat Höpfl R, et al. Spontaneous regression of CIN and delayed-type hypersensitivity to HPV16 oncoprotein E7. The Lancet. 2000;356:1985–6.CrossRef Höpfl R, et al. Spontaneous regression of CIN and delayed-type hypersensitivity to HPV16 oncoprotein E7. The Lancet. 2000;356:1985–6.CrossRef
Metadaten
Titel
The importance of HPV vaccination today
verfasst von
Reinhard Höpfl, MD
Publikationsdatum
01.02.2014
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 1/2014
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-014-0133-0

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