Skip to main content
Erschienen in: memo - Magazine of European Medical Oncology 3/2012

01.09.2012 | short review

ASH update 2011: chronic lymphocytic leukemia and indolent lymphoma

verfasst von: Michael Steurer, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

At the annual meeting of the American Society of Hematology (ASH) 2011, the focus in the field of chronic lymphocytic leukemia (CLL) and indolent lymphomas was again rather the translation of basic research results into early clinical trials than introducing new treatment standards. Although still at an early phase in the process of drug development, the results achievable with the Bruton’s tyrosine kinase inhibitor ibrutinib (formerly PCI-32765) in CLL and mantle cell lymphoma (MCL) are promising. Concerning clinical practice, new or updated results of trials exploring lenalidomide as well as new monoclonal antibodies (obinutuzumab, ofatumumab) in CLL/indolent lymphoma underscore the clinical value of these drugs, but their definite place in the respective treatment algorithm still needs to be defined.
Literatur
1.
Zurück zum Zitat Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376:1164–74.PubMedCrossRef Hallek M, Fischer K, Fingerle-Rowson G, et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet. 2010;376:1164–74.PubMedCrossRef
2.
Zurück zum Zitat Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol. 2010;28:1756–65.PubMedCrossRef Robak T, Dmoszynska A, Solal-Celigny P, et al. Rituximab plus fludarabine and cyclophosphamide prolongs progression-free survival compared with fludarabine and cyclophosphamide alone in previously treated chronic lymphocytic leukemia. J Clin Oncol. 2010;28:1756–65.PubMedCrossRef
3.
Zurück zum Zitat Fischer K, Cramer P, Stilgenbauer S, et al. Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: a multicenter phase II trial of the German CLL study group (GCLLSG). Blood (ASH Annual Meeting Abstracts). 2009;114:205. Fischer K, Cramer P, Stilgenbauer S, et al. Bendamustine combined with rituximab (BR) in first-line therapy of advanced CLL: a multicenter phase II trial of the German CLL study group (GCLLSG). Blood (ASH Annual Meeting Abstracts). 2009;114:205.
4.
Zurück zum Zitat Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27:4378–84.PubMedCrossRef Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol. 2009;27:4378–84.PubMedCrossRef
5.
Zurück zum Zitat Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116:2078–88.PubMedCrossRef Herman SE, Gordon AL, Wagner AJ, et al. Phosphatidylinositol 3-kinase-delta inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116:2078–88.PubMedCrossRef
6.
Zurück zum Zitat Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117:591–4.PubMedCrossRef Lannutti BJ, Meadows SA, Herman SE, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood. 2011;117:591–4.PubMedCrossRef
7.
Zurück zum Zitat Sharman J, de Vos S, Leonard JP, et al. A phase 1 study of the selective phosphatidylinositol 3-kinase-delta (PI3Kd) inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). Blood (ASH Ann Meeting Abstracts). 2011;118:1787. Sharman J, de Vos S, Leonard JP, et al. A phase 1 study of the selective phosphatidylinositol 3-kinase-delta (PI3Kd) inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). Blood (ASH Ann Meeting Abstracts). 2011;118:1787.
8.
Zurück zum Zitat Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463:88–92.PubMedCrossRef Davis RE, Ngo VN, Lenz G, et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010;463:88–92.PubMedCrossRef
9.
Zurück zum Zitat O’Brien S, Burger JA, Blum KA, et al. The Bruton’s tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): follow-up of a phase Ib/II study. Blood (ASH Annual Meeting Abstracts). 2011;118:983. O’Brien S, Burger JA, Blum KA, et al. The Bruton’s tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): follow-up of a phase Ib/II study. Blood (ASH Annual Meeting Abstracts). 2011;118:983.
10.
Zurück zum Zitat Ponader S, Buggy J, O’Brien S, et al. Bruton’s tyrosine kinase inhibitor PCI-32765 abrogates BCR- and nurselike cell-derived activation of CLL cells in vitro and in vivo. Blood (ASH Annual Meeting Abstracts). 2010;116:45.CrossRef Ponader S, Buggy J, O’Brien S, et al. Bruton’s tyrosine kinase inhibitor PCI-32765 abrogates BCR- and nurselike cell-derived activation of CLL cells in vitro and in vivo. Blood (ASH Annual Meeting Abstracts). 2010;116:45.CrossRef
11.
Zurück zum Zitat Egle A, Steurer M, Gassner F, et al. A combination of fludarabine/rituximab with escalating doses of lenalidomide in previously untreated chronic lymphocytic leukemia (CLL): the REVLIRIT CLL5 AGMT phase I/II study, clinical and exploratory analyses of induction results. Blood (ASH Annual Meeting Abstracts). 2011;118:292. Egle A, Steurer M, Gassner F, et al. A combination of fludarabine/rituximab with escalating doses of lenalidomide in previously untreated chronic lymphocytic leukemia (CLL): the REVLIRIT CLL5 AGMT phase I/II study, clinical and exploratory analyses of induction results. Blood (ASH Annual Meeting Abstracts). 2011;118:292.
12.
Zurück zum Zitat Ferrajoli A, O’Brien S, Wierda WG, et al. Combination therapy with ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL): results of a phase II trial. Blood (ASH Annual Meeting Abstracts). 2011;118:1788. Ferrajoli A, O’Brien S, Wierda WG, et al. Combination therapy with ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL): results of a phase II trial. Blood (ASH Annual Meeting Abstracts). 2011;118:1788.
13.
Zurück zum Zitat Wang L, Martin P, Blum KA, et al. The Bruton’s tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): preliminary results of a phase II trial. Blood (ASH Annual Meeting Abstracts). 2011;118:442. Wang L, Martin P, Blum KA, et al. The Bruton’s tyrosine kinase inhibitor PCI-32765 is highly active as single-agent therapy in previously-treated mantle cell lymphoma (MCL): preliminary results of a phase II trial. Blood (ASH Annual Meeting Abstracts). 2011;118:442.
14.
Zurück zum Zitat Press OW, Unger JM, Rimsza LM, et al. A phase III randomized intergroup trial (SWOG S0016) of CHOP chemotherapy plus rituximab Vs. CHOP chemotherapy plus iodine-131-Tositumomab for the treatment of newly diagnosed follicular non-Hodgkin’s lymphoma. Blood (ASH Annual Meeting Abstracts). 2011;118:98.CrossRef Press OW, Unger JM, Rimsza LM, et al. A phase III randomized intergroup trial (SWOG S0016) of CHOP chemotherapy plus rituximab Vs. CHOP chemotherapy plus iodine-131-Tositumomab for the treatment of newly diagnosed follicular non-Hodgkin’s lymphoma. Blood (ASH Annual Meeting Abstracts). 2011;118:98.CrossRef
15.
Zurück zum Zitat Fowler NH, Kahanic SP, Forero A, et al. Results of a phase II study with bendamustine and ofatumumab in untreated indolent B-Cell non-Hodgkin’s lymphoma. Blood (ASH Annual Meeting Abstracts). 2011;118:778.CrossRef Fowler NH, Kahanic SP, Forero A, et al. Results of a phase II study with bendamustine and ofatumumab in untreated indolent B-Cell non-Hodgkin’s lymphoma. Blood (ASH Annual Meeting Abstracts). 2011;118:778.CrossRef
16.
Zurück zum Zitat Sehn LH, Goy A, Offner FC, et al. Randomized phase II trial comparing GA101 (Obinutuzumab) with rituximab in patients with relapsed CD20 indolent B-Cell non-Hodgkin lymphoma: preliminary analysis of the GAUSS study. Blood (ASH Annual Meeting Abstracts). 2011;118:269. Sehn LH, Goy A, Offner FC, et al. Randomized phase II trial comparing GA101 (Obinutuzumab) with rituximab in patients with relapsed CD20 indolent B-Cell non-Hodgkin lymphoma: preliminary analysis of the GAUSS study. Blood (ASH Annual Meeting Abstracts). 2011;118:269.
Metadaten
Titel
ASH update 2011: chronic lymphocytic leukemia and indolent lymphoma
verfasst von
Michael Steurer, MD
Publikationsdatum
01.09.2012
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 3/2012
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-012-0041-0

Weitere Artikel der Ausgabe 3/2012

memo - Magazine of European Medical Oncology 3/2012 Zur Ausgabe