The role of radiochemotherapy in the multimodal treatment of pancreatic ductal adenocarcinoma: Standard procedure or individual decision?
Pancreatic carcinoma is one of the leading causes of cancer-related mortality and has an extremely poor prognosis. The management of locally advanced pancreatic cancer remains controversially discussed. Radiochemotherapy has been employed in different treatment protocols to improve local control and survival with patients suffering from local advanced but non-metastatic disease. The objective of this short review is to give a recent overview about the experiences with radiochemotherapy in the treatment of pancreatic cancer. Even if neoadjuvant, postoperative and definitive radiochemotherapy protocols offer a promising and feasible treatment option, the question about treatment indication and which patients benefit the most cannot yet be answered.