Neuro-oncology has become one of the liveliest sub-disciplines in oncology. More than forty compounds are currently investigated. The amount of neuro-oncologic publications and of their readers is steadily increasing. The image-change from the everlasting exception with special features in every category to a model for dynamic interdisciplinary research has occurred within the last ten years and is tightly related with Temozolomide (TMZ). One could even get the impression that the modern development of Neuro-oncology would not have been possible without Temozolomide.