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Onkologie 24. Februar 2009

New approaches to the treatment of adult acute lymphoblastic leukaemia

In this review we describe general therapeutic options for adult patients with acute lymphoblastic leukaemia and focus on specific new treatment strategies. Current novel approaches include monoclonal antibodies against leukaemic-associated antigens, new formulations of existing chemotherapeutic agents, new antimetabolites and nucleoside analogons and targeted molecular therapy. Some of these agents have already been adopted into standard regimens, leading to dramatically improved outcomes for example in mature B-ALL and in the formerly most unfavourable subgroup Philadelphia chromosome (Ph)/BCR-ABL-positive ALL, while others still remain in early phases of development.

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