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Molecular mechanisms of pharmacological doses of ascorbate on cancer cells

07/2015 Intravenous application of high-dose ascorbate (vitamin C) has been used in complementary medicine since the 1970s to treat cancer patients. In recent years it became evident that high-dose ascorbate in the millimolar range bears selective cytotoxic effects on cancer cells in vitro and in vivo. [...]

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Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines

07/2015 Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and [...]

Esthesioneuroblastoma metastatic to the neck and lung: a case report and review of the literature

07/2015 Esthesioneuroblastoma (ENB) is a rare tumor of the olfactory epithelium that has been shown to metastasize mostly to the lymph nodes of the neck but more rarely to other locations. We report on a rare case characterized by distant metastasis to the neck and lung. [...]

Role of FDG-PET/CT in staging and first-line treatment of Hodgkin and aggressive B-cell lymphomas

07/2015 Positron emission tomography with integrated computed tomography (PET/CT) is increasingly used for the initial staging, final or even interim (mid-treatment) response assessment in malignant lymphomas. Extensive clinical experience has been gained with Hodgkin lymphoma (HL) and aggressive B-cell non-Hodgkin lymphomas, including diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMLBCL) and other subtypes, which are the subject of the present review. [...]

Lung cancer in Bulgaria ‒ diagnosis, treatment, and factors affecting survival

07/2015 Bulgarian Single Institution experience in lung cancer treatment

Background: In Bulgaria, lung cancer incidence and mortality rates are rising in both men and women. The study aims to present a picture of lung cancer diagnosis and treatment process and to identify factors affecting survival in advanced lung cancer patients (LCP) treated with systemic therapy. [...]

The relevance of positron emission tomography response in non-small cell lung cancer

07/2015 Background: Most patients treated for lung cancer experience disease recurrence or progression, resulting in high mortality rates. Computed tomography (CT) is central in evaluating treatment response; however, positron emission tomography (PET) may provide a more rapid and prognostically relevant assessment of changes in disease activity during and after treatment. [...]

PET/CT in management of oncologic patients

07/2015 This issue of the journal contains review articles concerning the role of positron emission tomography (PET) in the management of oncologic patients.

Marino et al. describe a weak fluorodeoxyglucose (FDG) uptake in ductal carcinoma in situ and in invasive lobular carcinoma of the breast, while infiltrating ductal carcinoma has the highest FDG uptake among breast neoplasms. [...]

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