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Erschienen in: Wiener klinisches Magazin 6/2013

01.12.2013 | Nephrologie

Kardiovaskuläre Kalzifikationen bei Niereninsuffizienz

Ein Update

verfasst von: Dr. T. Krüger, G. Schlieper

Erschienen in: Wiener klinisches Magazin | Ausgabe 6/2013

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Zusammenfassung

Die Gefäßverkalkung in der Urämie ist nach wie vor eine der wesentlichen Herausforderungen in der Nephrologie. Kardiovaskuläre Komplikationen stehen an erster Stelle der Morbidität und Mortalität von Dialysepatienten. Das Verstehen der Zusammenhänge der Entstehung von Gefäßverkalkungen sowie ein Früherkennen von Patienten mit besonders hohem Risiko für kardiovaskuläre Komplikationen sowie mögliche neue Therapien sind für eine Präventivmedizin essenziell. Die bis vor einiger Zeit herrschende Meinung einer allein passiven Entstehung der Kalzifikation gilt als überholt und ist durch Ergebnisse abgelöst worden, die ein aktives biologisches Geschehen beschreiben. Die Entwicklungen in den letzten Jahren konnten zeigen, dass eine Reihe von Verkalkungsinhibitoren und zellulärer Mechanismen beteiligt sind. In dieser Übersichtsarbeit werden wir den aktuellen Stand der Pathomechanismen der Gefäßkalzifikation erläutern sowie diese letzten Erkenntnisse zusammenfassen. Darüber hinaus werden wir neue therapeutische Strategien diskutieren.
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Metadaten
Titel
Kardiovaskuläre Kalzifikationen bei Niereninsuffizienz
Ein Update
verfasst von
Dr. T. Krüger
G. Schlieper
Publikationsdatum
01.12.2013
Verlag
Springer Vienna
Erschienen in
Wiener klinisches Magazin / Ausgabe 6/2013
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI
https://doi.org/10.1007/s00740-013-0164-x

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