Skip to main content
Erschienen in: Wiener klinische Wochenschrift 23-24/2016

01.12.2016 | original article

Blood level of CD45+ platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease

verfasst von: Dr. Zufar Gabbasov, Sergey Kozlov, Svetlana Byazrova, Olga Saburova, Ivan Melnikov, Martin Caprnda, Eduard Curilla, Dr. Ludovit Gaspar, Dr. Peter Kruzliak, Vladimir Smirnov

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 23-24/2016

Einloggen, um Zugang zu erhalten

Summary

Objective

The aim of this study was to assess CD45-positive platelets (CD45+ platelets) involvement in restenosis development after drug-eluting stent (DES) implantation in patients with stable coronary artery disease (CAD).

Methods

The study comprised 126 male and female patients with stable angina pectoris, who underwent elective coronary stenting with DES and follow-up angiography within 6–12 months. The patients were assigned to the group with restenosis (n = 53) or group without restenosis (n = 73) according to the follow-up angiograms. In both groups we compared the level in blood of CD45+ platelets, the clinical, laboratory and angiographic variables, which may affect the development of restenosis. We have also constructed a logit regression model for prognosis of restenosis occurrence after DES implantation.

Results

The blood count of CD45+ platelets was higher in patients with restenosis than in patients without: 0.82 % (0.58; 1.12) vs. 0.34 % (0.20; 0.68), p < 0.001, data are expressed as median (lower quartile; upper quartile). By binary comparisons of more than 35 different clinical, laboratory and angiographic variables we identified 8 significant risk factors for the development of stent restenosis after DES. In order to define the risk of the development of restenosis, we have built a logit regression model. The resulting logit regression equation included the level of CD45+ platelets, the neutrophil to lymphocyte ratio (NLR), small diameter arteries stenting and the number of simultaneously implanted stents in one patient. Receiver operating characteristic (ROC) curve analysis has demonstrated the high prognostic value of the resulting logit regression equation with an area under the curve (AUC) of 0.91 % (p < 0.001).

Conclusions

The acquired data indicate the presence of a close relationship between circulating CD45+ platelets and restenosis development after DES implantation in patients with stable CAD.
Literatur
1.
Zurück zum Zitat Costa MA, Simon DI. Molecular basis of restenosis and drug-eluting stents. Circulation. 2005;111(17):2257–73.CrossRefPubMed Costa MA, Simon DI. Molecular basis of restenosis and drug-eluting stents. Circulation. 2005;111(17):2257–73.CrossRefPubMed
2.
Zurück zum Zitat Rajagopal V, Rockson SG. Coronary restenosis: a review of mechanisms and management. Am J Med. 2003;115(7):547–53.CrossRefPubMed Rajagopal V, Rockson SG. Coronary restenosis: a review of mechanisms and management. Am J Med. 2003;115(7):547–53.CrossRefPubMed
3.
Zurück zum Zitat Curcio A, Torella D, Indolfi C. Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy. Circ J. 2011;75(6):1287–96.CrossRefPubMed Curcio A, Torella D, Indolfi C. Mechanisms of smooth muscle cell proliferation and endothelial regeneration after vascular injury and stenting: approach to therapy. Circ J. 2011;75(6):1287–96.CrossRefPubMed
4.
Zurück zum Zitat Kawamoto R, Yamashita A, Nishihira K, et al. Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits. Pathol Res Pract. 2006;202(6):447–56.CrossRefPubMed Kawamoto R, Yamashita A, Nishihira K, et al. Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits. Pathol Res Pract. 2006;202(6):447–56.CrossRefPubMed
5.
Zurück zum Zitat Marx SO, Marks AR. Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation. 2001;104:852–825.CrossRefPubMed Marx SO, Marks AR. Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation. 2001;104:852–825.CrossRefPubMed
6.
Zurück zum Zitat Morris RE. Mechanisms of action of new immunosuppressive drugs. Ther Drug Monit. 1995;17:564–9.CrossRefPubMed Morris RE. Mechanisms of action of new immunosuppressive drugs. Ther Drug Monit. 1995;17:564–9.CrossRefPubMed
8.
Zurück zum Zitat Nebeker JR, Virmani R, Bennett CL, et al. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J Am Coll Cardiol. 2006;47(1):175–81.CrossRefPubMed Nebeker JR, Virmani R, Bennett CL, et al. Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project. J Am Coll Cardiol. 2006;47(1):175–81.CrossRefPubMed
9.
Zurück zum Zitat Finn AV, Nakazawa G, Joner M, et al. Vascular responses to drug eluting stents: importance of delayed healing. Arterioscler Thromb Vasc Biol. 2007;27(7):1500–10.CrossRefPubMed Finn AV, Nakazawa G, Joner M, et al. Vascular responses to drug eluting stents: importance of delayed healing. Arterioscler Thromb Vasc Biol. 2007;27(7):1500–10.CrossRefPubMed
10.
Zurück zum Zitat Evangelista V, Manarini S, Rotondo S, et al. Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P‑selectin and the beta 2 integrin CD11b/CD18. Blood. 1996;88(11):4183–94.PubMed Evangelista V, Manarini S, Rotondo S, et al. Platelet/polymorphonuclear leukocyte interaction in dynamic conditions: evidence of adhesion cascade and cross talk between P‑selectin and the beta 2 integrin CD11b/CD18. Blood. 1996;88(11):4183–94.PubMed
11.
Zurück zum Zitat Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI. Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis. JACC Cardiovasc Interv. 2011;4(10):1057–66.CrossRefPubMedPubMedCentral Inoue T, Croce K, Morooka T, Sakuma M, Node K, Simon DI. Vascular inflammation and repair: implications for re-endothelialization, restenosis, and stent thrombosis. JACC Cardiovasc Interv. 2011;4(10):1057–66.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Gabbasov Z, Ivanova O, Kogan-Yasny V, et al. Activated platelet chemiluminescence and presence of CD45+ platelets in patients with acute myocardial infarction. Platelets. 2014;25:405–8.CrossRefPubMed Gabbasov Z, Ivanova O, Kogan-Yasny V, et al. Activated platelet chemiluminescence and presence of CD45+ platelets in patients with acute myocardial infarction. Platelets. 2014;25:405–8.CrossRefPubMed
13.
Zurück zum Zitat Mehran R, Dangas G, Abizaid AS, et al. Angiographic patterns of in-stent restenosis: classification and implications for long-term outcome. Circulation. 1999;100:1872–8.CrossRefPubMed Mehran R, Dangas G, Abizaid AS, et al. Angiographic patterns of in-stent restenosis: classification and implications for long-term outcome. Circulation. 1999;100:1872–8.CrossRefPubMed
14.
Zurück zum Zitat Angelillo-Scherrer A. Leukocyte-derived microparticles in vascular homeostasis. Circ Res. 2012;110:356–63.CrossRefPubMed Angelillo-Scherrer A. Leukocyte-derived microparticles in vascular homeostasis. Circ Res. 2012;110:356–63.CrossRefPubMed
15.
Zurück zum Zitat Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101(8):841–3.CrossRefPubMed Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101(8):841–3.CrossRefPubMed
17.
Zurück zum Zitat Osterud B, Bjorklid E. Tissue factor in blood cells and endothelial cells. Front Biosci (Elite Ed). 2012;4:289–99.CrossRef Osterud B, Bjorklid E. Tissue factor in blood cells and endothelial cells. Front Biosci (Elite Ed). 2012;4:289–99.CrossRef
18.
Zurück zum Zitat Rauch U, Bonderman D, Bohrmann B, et al. Transfer of tissue factor from leukocytes is mediated byCD15 and tissue factor. Blood. 2000;96:170–5.PubMed Rauch U, Bonderman D, Bohrmann B, et al. Transfer of tissue factor from leukocytes is mediated byCD15 and tissue factor. Blood. 2000;96:170–5.PubMed
19.
Zurück zum Zitat Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106:1604–11.CrossRefPubMed Del Conde I, Shrimpton CN, Thiagarajan P, Lopez JA. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106:1604–11.CrossRefPubMed
20.
Zurück zum Zitat Shoji M, Koba S, Kobayashi Y. Roles of bone-marrow-derived cells and inflammatory Cytokines in Neointimal Hyperplasia after vascular injury. Biomed Res Int. 2014; doi:10.1155/2014/945127. Shoji M, Koba S, Kobayashi Y. Roles of bone-marrow-derived cells and inflammatory Cytokines in Neointimal Hyperplasia after vascular injury. Biomed Res Int. 2014; doi:10.​1155/​2014/​945127.
21.
Zurück zum Zitat Niccoli G, Montone RA, Ferrante G, Crea F. The evolving role of inflammatory biomarkers in risk assessment after stent implantation. J Am Coll Cardiol. 2010;56(22):1783–93.CrossRefPubMed Niccoli G, Montone RA, Ferrante G, Crea F. The evolving role of inflammatory biomarkers in risk assessment after stent implantation. J Am Coll Cardiol. 2010;56(22):1783–93.CrossRefPubMed
22.
Zurück zum Zitat Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta. 2008;395:27–31.CrossRefPubMed Papa A, Emdin M, Passino C, Michelassi C, Battaglia D, Cocci F. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta. 2008;395:27–31.CrossRefPubMed
23.
Zurück zum Zitat Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107(3):433–8.CrossRefPubMed Uthamalingam S, Patvardhan EA, Subramanian S, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107(3):433–8.CrossRefPubMed
24.
Zurück zum Zitat Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol. 2006;97(7):993–6.CrossRefPubMed Duffy BK, Gurm HS, Rajagopal V, Gupta R, Ellis SG, Bhatt DL. Usefulness of an elevated neutrophil to lymphocyte ratio in predicting long-term mortality after percutaneous coronary intervention. Am J Cardiol. 2006;97(7):993–6.CrossRefPubMed
25.
Zurück zum Zitat Balli M, Taşolar H, Çetin M, Tekin K, Çağliyan ÇE, Türkmen S, Yilmaz M, Elbasan Z, Şahin DY, Çayli M. Use of the neutrophil to lymphocyte ratio for prediction of in-stent restenosis in bifurcation lesions. Eur Rev Med Pharmacol Sci. 2015;19(10):1866–73.PubMed Balli M, Taşolar H, Çetin M, Tekin K, Çağliyan ÇE, Türkmen S, Yilmaz M, Elbasan Z, Şahin DY, Çayli M. Use of the neutrophil to lymphocyte ratio for prediction of in-stent restenosis in bifurcation lesions. Eur Rev Med Pharmacol Sci. 2015;19(10):1866–73.PubMed
26.
Zurück zum Zitat Turak O, Ozcan F, Isleyen A. Usefulness of the neutrophil-to-lymphocyte ratio to predict bare-metal stent restenosis. Am J Cardiol. 2012;110:1405–10.CrossRefPubMed Turak O, Ozcan F, Isleyen A. Usefulness of the neutrophil-to-lymphocyte ratio to predict bare-metal stent restenosis. Am J Cardiol. 2012;110:1405–10.CrossRefPubMed
Metadaten
Titel
Blood level of CD45+ platelets and development of restenosis after drug-eluting stent implantation in patients with stable coronary artery disease
verfasst von
Dr. Zufar Gabbasov
Sergey Kozlov
Svetlana Byazrova
Olga Saburova
Ivan Melnikov
Martin Caprnda
Eduard Curilla
Dr. Ludovit Gaspar
Dr. Peter Kruzliak
Vladimir Smirnov
Publikationsdatum
01.12.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 23-24/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1074-x

Weitere Artikel der Ausgabe 23-24/2016

Wiener klinische Wochenschrift 23-24/2016 Zur Ausgabe

mitteilungen der gesellschaft der ärzte in wien

Veranstaltungen