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Erschienen in: Wiener klinische Wochenschrift 21-22/2015

01.11.2015 | original article

Evaluation of electrocardiographic parameters in patients with diabetes insipidus

verfasst von: Assoc. Prof. Ferhat Deniz, Assoc. Prof. Alper Kepez, Seyit Ahmet Ay, MD, Prof. Okan Ergogan, Kamil Baskoy, MD, Mustafa Nuri Guncıkan, Zekeriya Dogan, MD, Assoc. Prof. Arif Yonem

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2015

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Summary

Background

There is limited data regarding the effect of altered serum osmolality on cardiac electrical activity. The aim of the present study is to evaluate the electrocardiographic (ECG) effects of diabetes insipidus (DI) and any related hyperosmolality in a population of young patients with DI and without any known cardiovascular disease or risk factors.

Methods

Twelve-lead ECG’s of 44 consecutive untreated young male patients (age: 21.8 ± 2.9 years) who had been referred to endocrinology clinic and diagnosed as DI based on water deprivation test were retrospectively evaluated. A total of 30 age-matched (21.9 ± 2.4 years) healthy males were selected as control group and ECG’s of these controls were obtained for comparison with ECG’s of DI patients. All ECG parameters were measured and compared.

Results

Duration of QRS complex was significantly shorter in patients with DI compared with controls (85.2 ± 12.0 vs. 94.0 ± 10.6 ms, p: 0.001). P wave dispersion (PWD) of patients with DI was significantly higher compared with controls (31.9 ± 9.9 vs. 26.5 ± 10.6 ms, p: 0.03) and it was significantly correlated with serum osmolality and serum sodium level (r = − 0.36, p: 0.02 and r: − 0.35, p: 0.02, respectively).

Conclusions

DI patients without any cardiovascular disease or risk factors displayed significantly shorter QRS duration and increased p wave dispersion compared with controls.
Literatur
1.
Zurück zum Zitat Majzoub JA, Srivatsa A. Diabetes insipidus: clinical and basic aspects. Pediatr Endocrinol Rev. 2006;4(1):60–5.PubMed Majzoub JA, Srivatsa A. Diabetes insipidus: clinical and basic aspects. Pediatr Endocrinol Rev. 2006;4(1):60–5.PubMed
3.
Zurück zum Zitat Zablockaite D, Gendviliene V, Macianskiene R, et al. Effect of hyperosmolarity on beta2-adrenergic stimulation in human atrium. Medicana (Kaunas). 2005;41:401–5. Zablockaite D, Gendviliene V, Macianskiene R, et al. Effect of hyperosmolarity on beta2-adrenergic stimulation in human atrium. Medicana (Kaunas). 2005;41:401–5.
4.
Zurück zum Zitat Ogura T -, You Y, McDonald TF. Membrane currents underlying the modified electrical activity of guinea-pig ventricular myocytes exposed to hyperosmotic solution. J Physiol. 1997;504(1):135–51.CrossRefPubMedPubMedCentral Ogura T -, You Y, McDonald TF. Membrane currents underlying the modified electrical activity of guinea-pig ventricular myocytes exposed to hyperosmotic solution. J Physiol. 1997;504(1):135–51.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Kasamaki Y, Guo AC, Shuba LM, Ogura T, McDonald TF. Potassium current and sodium pump involvement in the positive inotropy of cardiac muscle during hyperosmotic stress. Can J Cardiol. 1998;14:285–94.PubMed Kasamaki Y, Guo AC, Shuba LM, Ogura T, McDonald TF. Potassium current and sodium pump involvement in the positive inotropy of cardiac muscle during hyperosmotic stress. Can J Cardiol. 1998;14:285–94.PubMed
6.
Zurück zum Zitat Akiyama T, Fozzard HA. Influence of potassium ions and osmolality on the resting membrane potential of rabbit ventricular papillary muscle with estimation of the activity and the activity coefficient of internal potassium. Circ Res. 1975;37:621–9.CrossRefPubMed Akiyama T, Fozzard HA. Influence of potassium ions and osmolality on the resting membrane potential of rabbit ventricular papillary muscle with estimation of the activity and the activity coefficient of internal potassium. Circ Res. 1975;37:621–9.CrossRefPubMed
7.
Zurück zum Zitat Hermsmeyer K, Rulon R, Sperelakis N. Loss of the plateau of the cardiac action potential in hypertonic solutions. J Gen Physiol. 1972;59:779–93.CrossRefPubMedPubMedCentral Hermsmeyer K, Rulon R, Sperelakis N. Loss of the plateau of the cardiac action potential in hypertonic solutions. J Gen Physiol. 1972;59:779–93.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Ehara T, Hasegawa J. Effects of hypertonic solution on action potential and input resistance in the guinea-pig ventricular muscle. Jpn J Physiol. 1983;33:151–67.CrossRefPubMed Ehara T, Hasegawa J. Effects of hypertonic solution on action potential and input resistance in the guinea-pig ventricular muscle. Jpn J Physiol. 1983;33:151–67.CrossRefPubMed
9.
Zurück zum Zitat Ogura T, You Y, McDonald TF. Membrane currents underlying the modified electrical activity of guinea-pig ventricular myocytes exposed to hyperosmotic solution. J Physiol (Lond). 1997;504:135–51.CrossRef Ogura T, You Y, McDonald TF. Membrane currents underlying the modified electrical activity of guinea-pig ventricular myocytes exposed to hyperosmotic solution. J Physiol (Lond). 1997;504:135–51.CrossRef
10.
Zurück zum Zitat Ogura T, Matsuda H, Shibamoto T, Imanishi S. Osmosensitive properties of rapid and slow delayed rectifier K + currents in guinea-pig heart cells. Clin Exp Pharmacol Physiol. 2003;30:616–22.CrossRefPubMed Ogura T, Matsuda H, Shibamoto T, Imanishi S. Osmosensitive properties of rapid and slow delayed rectifier K + currents in guinea-pig heart cells. Clin Exp Pharmacol Physiol. 2003;30:616–22.CrossRefPubMed
11.
Zurück zum Zitat Wass J. How to do a water deprivation test: interpretation of results. Presented at Society for Endocrinology BES 2008 Harrogate, UK. Endocrine Abstracts. 2008;15:S61. Wass J. How to do a water deprivation test: interpretation of results. Presented at Society for Endocrinology BES 2008 Harrogate, UK. Endocrine Abstracts. 2008;15:S61.
12.
Zurück zum Zitat Deniz F, Basaran Y. Neurohypophysis tests. In Deniz F, Basaran Y, editors. Endokrinoloji ve Metabolizma Hastalıklarında Kulllanılan Dinamik Testler, 1th edition (Turkish). Ankara: Dumat Ofset Matbacilik; 2013. pp. 49–51. Deniz F, Basaran Y. Neurohypophysis tests. In Deniz F, Basaran Y, editors. Endokrinoloji ve Metabolizma Hastalıklarında Kulllanılan Dinamik Testler, 1th edition (Turkish). Ankara: Dumat Ofset Matbacilik; 2013. pp. 49–51.
13.
Zurück zum Zitat Surawicz B, Childers R, Deal BJ, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation. 2009;119;e235–40.CrossRefPubMed Surawicz B, Childers R, Deal BJ, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventricular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation. 2009;119;e235–40.CrossRefPubMed
14.
Zurück zum Zitat Warner RA, Travis A, Lawson WT, Hill NE, Wagner GS. Directional analysis of the 12-lead electrocardiogram. Proceedings of the IEEE Computers in Cardiology. 1997;24:733–6. Warner RA, Travis A, Lawson WT, Hill NE, Wagner GS. Directional analysis of the 12-lead electrocardiogram. Proceedings of the IEEE Computers in Cardiology. 1997;24:733–6.
15.
Zurück zum Zitat El-Sherif N, Turitto G. Electrolyte disorders and arrhythmogenesis. Cardiol J. 2011;18:233–45.PubMed El-Sherif N, Turitto G. Electrolyte disorders and arrhythmogenesis. Cardiol J. 2011;18:233–45.PubMed
16.
Zurück zum Zitat Mirvis DM, Goldberger AL. Electrocardiography. In: Libby P, Bonow RO, Mann DL, Zipes DP, Braunwald E, editors. Braunwald’s heart disease: a textbook of cardiovascular medicine, 9th ed. Philadelphia: Saunders: 2011, pp. 126–67. Mirvis DM, Goldberger AL. Electrocardiography. In: Libby P, Bonow RO, Mann DL, Zipes DP, Braunwald E, editors. Braunwald’s heart disease: a textbook of cardiovascular medicine, 9th ed. Philadelphia: Saunders: 2011, pp. 126–67.
17.
Zurück zum Zitat Rubart M, Zipes DP. Genesis of cardiac arrhythmias: electrophysiologic considerations. In: Libby P, Bonow RO, Mann DL, Zipes DP, Braunwald E, editors. Braunwald’s heart disease: a textbook of cardiovascular medicine. 9th ed. Philadelphia: Saunders; 2011. pp. 653–86. Rubart M, Zipes DP. Genesis of cardiac arrhythmias: electrophysiologic considerations. In: Libby P, Bonow RO, Mann DL, Zipes DP, Braunwald E, editors. Braunwald’s heart disease: a textbook of cardiovascular medicine. 9th ed. Philadelphia: Saunders; 2011. pp. 653–86.
18.
Zurück zum Zitat Aytemir K, Ozer N, Atalar E, et al. P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol. 2000;23:1109–12.CrossRefPubMed Aytemir K, Ozer N, Atalar E, et al. P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol. 2000;23:1109–12.CrossRefPubMed
Metadaten
Titel
Evaluation of electrocardiographic parameters in patients with diabetes insipidus
verfasst von
Assoc. Prof. Ferhat Deniz
Assoc. Prof. Alper Kepez
Seyit Ahmet Ay, MD
Prof. Okan Ergogan
Kamil Baskoy, MD
Mustafa Nuri Guncıkan
Zekeriya Dogan, MD
Assoc. Prof. Arif Yonem
Publikationsdatum
01.11.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0874-8

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