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Erschienen in: Wiener klinische Wochenschrift 9-10/2014

01.05.2014 | original article

Early atherosclerosis in HIV-infected patients below the age of 55 years: Slovenian national study

verfasst von: Mateja Pirs, MD, Barbara Eržen, PhD, Prof. Mišo Šabović, PhD, Primož Karner, Ludvik Vidmar, Prof. Mario Poljak, PhD, Borut Jug, PhD, Mojca Mikac, Prof. Janez Tomažič, PhD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2014

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Summary

Background

Increased life expectancy of human immunodeficiency virus (HIV)-infected patients appears to be coupled with increased incidence of cardiovascular disease (CVD).

Aim

The aim of our study was to determine the presence of early atherosclerosis among Slovenian HIV-infected patients below the age of 55 years.

Methods

A total of 86 HIV-infected male patients below the age of 55 years participated in our study. Ankle-brachial index (ABI) was measured using a handheld Doppler ultrasonic probe and a blood pressure cuff. Carotid intima-media thickness (CIMT) was assessed by the B-mode high-resolution ultrasound technique. Low ABI, CIMT > 0.8 mm or presence of carotid plaques were considered markers of early atherosclerosis.

Results

Average CIMT was lowest among treatment-naïve patients (0.65 mm); 10 (38.4 %) had CIMT > 0.8 mm, and carotid plaques were detected in 1 (3.8 %). Average CIMT among treated patients was 0.71 mm; 30 (50.0 %) had CIMT > 0.8 mm, and plaques were detected in 11 (18.3 %). Low ABI (≤ 0.90) was found in five patients (5.8 %) without symptoms of peripheral artery disease; two were treatment-naïve, and three received antiretroviral therapy. Early atherosclerosis was found in 43 (50.0 %) patients; 10 (38.4 %) were in treatment-naïve and 33 (55.0 %) in the treated group.

Conclusions

Increased prevalence of early atherosclerosis among Slovenian HIV-infected patients below the age of 55 years has been demonstrated. Screening for early atherosclerosis should be implemented in the evaluation of young HIV-infected patients because a more aggressive treatment approach, aimed to delay the progression of atherosclerosis, may be warranted especially when carotid plaques are detected. We have shown that although ABI contributes to CVD risk assessment, CIMT assessment remains the more sensitive method.
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Metadaten
Titel
Early atherosclerosis in HIV-infected patients below the age of 55 years: Slovenian national study
verfasst von
Mateja Pirs, MD
Barbara Eržen, PhD
Prof. Mišo Šabović, PhD
Primož Karner
Ludvik Vidmar
Prof. Mario Poljak, PhD
Borut Jug, PhD
Mojca Mikac
Prof. Janez Tomažič, PhD
Publikationsdatum
01.05.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0516-6

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