Effects ofHelicobacter pylori eradication on proteinuria: a prospective study

Helicobacter pylori is one of the most common bacterial infections, seen in humans worldwide and its possible relationship to different diseases is a focus of attention nowadays. The aim of this study was to analyse the effects ofH. Pylori eradication on proteinuria.

Ninety-nine patients suffering from dyspeptic complaints were recruited in this prospective study. The patients were divided into two groups according to the presence ofH. pylori infection. Thus, a total of 67 H. pylori positive and 32 H. pylori negative patients were studied. TheH. pylori positive patients’ group was divided into two groups according to response toH. pylori eradication treatment. A total of three groups were formed, viz; group 1 comprises of patients who areH. pylori positive and responds positively toH. pylori eradication therapy, group 2 comprises of patients who areH. pylori positive and responds negatively toH. pylori eradication therapy and group 3 is the control group and comprises of patients that areH. pylori negative. Urine samples to obtain the protein/creatinine ratio were collected initially and at the end of the study from all patients.

Mean difference levels (pre- and post-treatment difference) of urine protein/creatinine ratio was 0.055 ± 0.13 in group 1. The ratio was − 0.0007 ± 0.0067 in group 2 and − 0.0022 ± 0.008 in group 3. A statistically significant difference was found in group 1 compared to the other groups in terms of mean difference levels of protein/creatinine ratios (p < 0.001).