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Endokrinologie 24. Juni 2016

Insulin adsorption by infusion sets in the setting of treatment of hyperkalaemia

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Critical hyperkalaemia is a potentially life-threatening emergency, requiring timely treatment with an intravenous infusion of a combination of glucose and soluble insulin. Most intravenous infusion systems use polyvinyl chloride (PVC) or polyurethane tubings, which are hydrophobic and adsorb insulin.

Insulin adsorption is dependent on the infusion rate, insulin concentration, tubing material, and whether the tubing surface has been primed. Insulin adsorption on various infusion tubings has been studied in the setting of glycaemic control, where losses of > 50 % of insulin activity has been reported, and occurs mostly in the first 30 min of infusion. We examined the extent of insulin adsorption in syringe and burette delivery systems for intravenous insulin infusion in the setting of treatment of hyperkalaemia, which typically uses infusion rates much higher than for glycaemic control.

Kai Ng, Jillian Yeo, Felicia Woo, Jennifer Wong, Sunil Sethi, Dr. Tze Loh, Wiener klinische Wochenschrift 11/12/2016

Volltext dieses Beitrags / entire article auf SpringerLink

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