Lyme borreliosis in 2005, 30 years after initial observations in Lyme Connecticut
Nearly 100 years ago, Afzelius described a patient with an expanding skin lesion, called erythema migrans , which is now known to be the initial skin manifestation of Lyme borreliosis. Approximately 70 years later, in 1976, epidemiologic evaluation of a cluster of children with arthritis in Lyme, Connecticut  led to a complete description of the infection . During the subsequent years, investigators in a number of countries have made remarkable strides in the elucidation of this tick-borne spirochetal infection. The purpose of this review is to discuss the current status of Lyme borreliosis, including areas in which knowledge of the infection is still incomplete.