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Innere Medizin 1. September 2008

Striking response with bevacizumab and chemotherapy in a woman with heavily pretreated breast cancer

In pretreated breast cancer, encouraging therapy responses are regularly achieved by applying innovative therapies. We present here a case report of a woman with a 10-year history of breast cancer with continuous progression despite multiple therapies. Ultimately, ascitic effusion developed, massively disturbing her quality of life. A combination of bevacizumab and mitoxantrone/methotrexate chemotherapy led to a striking, response on liver metastasis and effusion generation, with great clinical benefit. Our case highlights previous observations that bevacizumab is beneficial in inhibiting the production of malignant effusion.

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