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Innere Medizin 1. März 2008

Targeted delivery of TNF using NGR-TNF in combination with chemotherapy as an effective and tolerabl

Targeted delivery of TNF to tumour vessels has been achieved by coupling this protein with the CNGRC peptide, an aminopeptidase N (CD13) ligand that targets the tumour neovasculature.The so-called NGR-TNF enhances the penetration of chemotherapeutic drugs in tumours and improves their efficacy. Here we describe a case of hepatocarcinoma which showed response to NGR-hTNF in combination with doxorubicin, clinically proving this promising strategy.

M. Giovannini, V. Gregorc, M. G. Viganò, E. Roca, C. Lazzari, A. Spreafico, C. Belli, G. Citterio, G. Rossoni, G. Donadoni, A. Corti, E. Villa, F. C. Cappio, memo - Magazine of European Medical Oncology

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