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Erschienen in: Wiener Medizinische Wochenschrift 3-4/2017

01.03.2017 | main topic

Cutaneous and visceral leishmaniasis during anti-TNFα therapy

verfasst von: Claudio Guarneri, M.D., Valentina Bevelacqua, M.D., Ph.D., Prof. James W. Patterson, M.D., Prof. Georgi Tchernev

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 3-4/2017

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Summary

The long-term use of novel antipsoriatic systemic biotechnological drugs may increase susceptibility to opportunistic infections. Several cases of visceral leishmaniasis have been reported in immunosuppressed individuals, including those who have been treated with tumour necrosis factor alpha (TNFα) blocking agents. Simultaneous occurrence of cutaneous and visceral involvement has been more rarely recorded in the medical literature. Herein, we describe a case of mucosal leishmaniasis occurring in a farmer living in an endemic region, who was treated with golimumab because of psoriatic arthritis. This highlights the importance of recognizing cutaneous lesions as a first indicator of possible underlying kala-azar disease.
Literatur
1.
Zurück zum Zitat Guarneri C, Tchernev G, Bevelacqua V, Lotti T, Nunnari G. The unwelcome trio: HIV plus cutaneous and visceral leishmaniasis. Dermatol Ther. 2016;29(2):88–91.CrossRefPubMed Guarneri C, Tchernev G, Bevelacqua V, Lotti T, Nunnari G. The unwelcome trio: HIV plus cutaneous and visceral leishmaniasis. Dermatol Ther. 2016;29(2):88–91.CrossRefPubMed
2.
Zurück zum Zitat Guarneri C, Vaccaro M, Cannavò SP, Borgia F, Guarneri B. Erythematous-edematous-infiltrative plaque on the face: cutaneous angio-lupoid leishmaniasis. Eur J Dermatol. 2002;12(6):597–9.PubMed Guarneri C, Vaccaro M, Cannavò SP, Borgia F, Guarneri B. Erythematous-edematous-infiltrative plaque on the face: cutaneous angio-lupoid leishmaniasis. Eur J Dermatol. 2002;12(6):597–9.PubMed
3.
Zurück zum Zitat Piaserico S, Conti A, Lo Console F, De Simone C, Prestinari F, Mazzotta A, Gualdi G, Guarneri C, Borsari S, Cassano N. Efficacy and safety of systemic treatments for psoriasis in elderly patients. Acta Derm Venereol. 2014;94(3):293–7.CrossRefPubMed Piaserico S, Conti A, Lo Console F, De Simone C, Prestinari F, Mazzotta A, Gualdi G, Guarneri C, Borsari S, Cassano N. Efficacy and safety of systemic treatments for psoriasis in elderly patients. Acta Derm Venereol. 2014;94(3):293–7.CrossRefPubMed
4.
Zurück zum Zitat Ali T, Bronze MS, Kaitha S, Mahmood S, Ftaisi A, Stone J. Clinical use of anti-TNF therapy and increased risk of infections. Drug Healthc Patient Saf. 2013;5:79–99.CrossRefPubMedPubMedCentral Ali T, Bronze MS, Kaitha S, Mahmood S, Ftaisi A, Stone J. Clinical use of anti-TNF therapy and increased risk of infections. Drug Healthc Patient Saf. 2013;5:79–99.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Amerio P, Amoruso G, Bardazzi F, Campanati A, Cassano N, Conti A, Gisondi P, Guarneri C, Mazzotta A, Piaserico S, Prestinari F, Prignano F, Zane C, de Simone C. Detection and management of latent tuberculosis infections before biologic therapy for psoriasis. J Dermatolog Treat. 2013;24(4):305–11.CrossRefPubMed Amerio P, Amoruso G, Bardazzi F, Campanati A, Cassano N, Conti A, Gisondi P, Guarneri C, Mazzotta A, Piaserico S, Prestinari F, Prignano F, Zane C, de Simone C. Detection and management of latent tuberculosis infections before biologic therapy for psoriasis. J Dermatolog Treat. 2013;24(4):305–11.CrossRefPubMed
6.
Zurück zum Zitat Guarneri C, Guarneri F. Symmetrical cutaneous leishmaniasis. Acta Derm Venereol. 2005;85(3):281–2.PubMed Guarneri C, Guarneri F. Symmetrical cutaneous leishmaniasis. Acta Derm Venereol. 2005;85(3):281–2.PubMed
7.
Zurück zum Zitat Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis. 2004;27:305–18.CrossRefPubMed Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis. 2004;27:305–18.CrossRefPubMed
8.
Zurück zum Zitat Alvar J, Velez ID, Bern C, Herrero M, Desieux P. WHO Leishmaniasis Control Team: leishmaniasis worldwide and global estimates of its incidence. PLOS ONE. 2012;7:e35671.CrossRefPubMedPubMedCentral Alvar J, Velez ID, Bern C, Herrero M, Desieux P. WHO Leishmaniasis Control Team: leishmaniasis worldwide and global estimates of its incidence. PLOS ONE. 2012;7:e35671.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Monge-Maillo B, Norman FF, Cruz I, Alvar J, López-Vélez R. Visceral leishmaniasis and HIV coinfection in the Mediterranean region. PLOS Negl Trop Dis. 2014;8(8):e3021.CrossRefPubMedPubMedCentral Monge-Maillo B, Norman FF, Cruz I, Alvar J, López-Vélez R. Visceral leishmaniasis and HIV coinfection in the Mediterranean region. PLOS Negl Trop Dis. 2014;8(8):e3021.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Borgia F, Vaccaro M, Guarneri F, Manfrè C, Cannavò SP, Guarneri C. Mucosal leishmaniasis occurring in a renal transplant recipient. Dermatology (Basel). 2001;202(3):266–7.CrossRef Borgia F, Vaccaro M, Guarneri F, Manfrè C, Cannavò SP, Guarneri C. Mucosal leishmaniasis occurring in a renal transplant recipient. Dermatology (Basel). 2001;202(3):266–7.CrossRef
11.
Zurück zum Zitat Celesia BM, Cacopardo B, Massimino D, Gussio M, Tosto S, Nunnari G, Pinzone MR. Atypical presentation of PKDL due to leishmania infantum in an HIV-infected patient with relapsing visceral leishmaniasis. Case Rep Infect Dis. 2014;2014:370286.PubMedPubMedCentral Celesia BM, Cacopardo B, Massimino D, Gussio M, Tosto S, Nunnari G, Pinzone MR. Atypical presentation of PKDL due to leishmania infantum in an HIV-infected patient with relapsing visceral leishmaniasis. Case Rep Infect Dis. 2014;2014:370286.PubMedPubMedCentral
12.
Zurück zum Zitat Català A, Roè E, Dalmau J, Pomar V, Munoz C, Yelamos O, Puig L. Anti-tumour necrosis factor-induced visceral and cutaneous leishmaniasis: case report and review of the literature. Dermatology (Basel). 2015;230:204–7.CrossRef Català A, Roè E, Dalmau J, Pomar V, Munoz C, Yelamos O, Puig L. Anti-tumour necrosis factor-induced visceral and cutaneous leishmaniasis: case report and review of the literature. Dermatology (Basel). 2015;230:204–7.CrossRef
13.
Zurück zum Zitat Vaccaro M, Magaudda L, Cutroneo G, Trimarchi F, Barbuzza O, Guarneri F, Guarneri B. Changes in the distribution of laminin α1 chain in psoriatic skin: immunohistochemical study using confocal laser scanning microscopy. Br J Dermatol. 2002;146(3):392–8.CrossRefPubMed Vaccaro M, Magaudda L, Cutroneo G, Trimarchi F, Barbuzza O, Guarneri F, Guarneri B. Changes in the distribution of laminin α1 chain in psoriatic skin: immunohistochemical study using confocal laser scanning microscopy. Br J Dermatol. 2002;146(3):392–8.CrossRefPubMed
14.
Zurück zum Zitat Guarneri F, Guarneri C, Guarneri B. Biologic agents in the treatment of psoriasis. Recent Pat Inflamm Allergy Drug Discov. 2007;1(3):193–217.CrossRefPubMed Guarneri F, Guarneri C, Guarneri B. Biologic agents in the treatment of psoriasis. Recent Pat Inflamm Allergy Drug Discov. 2007;1(3):193–217.CrossRefPubMed
15.
Zurück zum Zitat Gisondi P, Amerio P, Amoroso GF, Antonucci VA, Bardazzi F, Buongiorno MR, Bruni P, Campanati A, Caproni M, Carlesimo M, Carrera CG, Cianchino G, Cimmino G, Costanzo A, Cozzani E, Dapavo P, D’amico D, De Simone C, Del Giglio M, Di Nuzzo S, Gai F, Galluccio AG, Goffredo A, Gualdi G, Guarneri C, Kokelj F, Lasagni C, Loconsole F, Longo V, Malagoli P, Miracapillo A, Mugheddu C, Parodi A, Pellegrino M, Peserico A, Piaserico S, Pistone G, Potenza C, Plumari A, Stingeni L, Strippoli D, Travaglino M, Girolomoni G. Optimization of systemic treatments for chronic plaque psoriasis. Recommendations for switching and transitioning. G Ital Dermatol Venereol. 2013;148(6 Suppl 1):1–10.PubMed Gisondi P, Amerio P, Amoroso GF, Antonucci VA, Bardazzi F, Buongiorno MR, Bruni P, Campanati A, Caproni M, Carlesimo M, Carrera CG, Cianchino G, Cimmino G, Costanzo A, Cozzani E, Dapavo P, D’amico D, De Simone C, Del Giglio M, Di Nuzzo S, Gai F, Galluccio AG, Goffredo A, Gualdi G, Guarneri C, Kokelj F, Lasagni C, Loconsole F, Longo V, Malagoli P, Miracapillo A, Mugheddu C, Parodi A, Pellegrino M, Peserico A, Piaserico S, Pistone G, Potenza C, Plumari A, Stingeni L, Strippoli D, Travaglino M, Girolomoni G. Optimization of systemic treatments for chronic plaque psoriasis. Recommendations for switching and transitioning. G Ital Dermatol Venereol. 2013;148(6 Suppl 1):1–10.PubMed
16.
Zurück zum Zitat Tobin AM, Kirby B. TNF alpha inhibitors in the treatment of psoriasis and psoriatic arthritis. BioDrugs. 2005;19(1):47–57.CrossRefPubMed Tobin AM, Kirby B. TNF alpha inhibitors in the treatment of psoriasis and psoriatic arthritis. BioDrugs. 2005;19(1):47–57.CrossRefPubMed
17.
Zurück zum Zitat Tchernev G, Guarneri C, Bevelacqua V, Wollina U. Carcinoma cuniculatum in course of etanercept: blocking autoimmunity but propagation of carcinogenesis? Int J Immunopathol Pharmacol. 2014;27(2):261–6.CrossRefPubMed Tchernev G, Guarneri C, Bevelacqua V, Wollina U. Carcinoma cuniculatum in course of etanercept: blocking autoimmunity but propagation of carcinogenesis? Int J Immunopathol Pharmacol. 2014;27(2):261–6.CrossRefPubMed
18.
Zurück zum Zitat Cintolo M, Guarneri C, Lentini M. A case of molluscum contagiosum infection in a patient with Crohn’s disease, receiving combination therapy with azathioprine and adalimumab. J Crohns Colitis. 2015;9(7):593–4.CrossRefPubMed Cintolo M, Guarneri C, Lentini M. A case of molluscum contagiosum infection in a patient with Crohn’s disease, receiving combination therapy with azathioprine and adalimumab. J Crohns Colitis. 2015;9(7):593–4.CrossRefPubMed
19.
Zurück zum Zitat Guarneri C, Wollina U, Chokoeva A, Lotti TM, Tchernev G. A strange infiltrative plaque on the face. Braz J Infect Dis. 2016;20(2):214–5.CrossRefPubMed Guarneri C, Wollina U, Chokoeva A, Lotti TM, Tchernev G. A strange infiltrative plaque on the face. Braz J Infect Dis. 2016;20(2):214–5.CrossRefPubMed
20.
Zurück zum Zitat Postigo C, Llamas R, Zarco C, Rubio R, Pulido F, Costa JR, Iglesias L. Cutaneous lesions in patients with visceral leishmaniasis. J Infect. 1997;35:265–8.CrossRefPubMed Postigo C, Llamas R, Zarco C, Rubio R, Pulido F, Costa JR, Iglesias L. Cutaneous lesions in patients with visceral leishmaniasis. J Infect. 1997;35:265–8.CrossRefPubMed
21.
Zurück zum Zitat Donati P, Paolino G, Panetta C, Muscardin L, Cota C, Giuliani M. Visceral leishmaniasis revealed by a squamous cell carcinoma in an HIV-1 infected patient. Infection. 2013;41:575–8.CrossRefPubMed Donati P, Paolino G, Panetta C, Muscardin L, Cota C, Giuliani M. Visceral leishmaniasis revealed by a squamous cell carcinoma in an HIV-1 infected patient. Infection. 2013;41:575–8.CrossRefPubMed
22.
Zurück zum Zitat Alvar J, Aparicio P, Aseffa A, Den Boer M, Cañavate C, Dedet JP, Gradoni L, Ter HR, López-Vélez R, Moreno J. The relationship betweeen leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev. 2008;21:334–59.CrossRefPubMedPubMedCentral Alvar J, Aparicio P, Aseffa A, Den Boer M, Cañavate C, Dedet JP, Gradoni L, Ter HR, López-Vélez R, Moreno J. The relationship betweeen leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev. 2008;21:334–59.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Colebunders R, Depraetere K, Verstraeten T, Lambert J, Hauben E, Van Marck E, Maurer T, Banuls AL, Dujardin JC. Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection. J Am Acad Dermatol. 1999;41:847–50.CrossRefPubMed Colebunders R, Depraetere K, Verstraeten T, Lambert J, Hauben E, Van Marck E, Maurer T, Banuls AL, Dujardin JC. Unusual cutaneous lesions in two patients with visceral leishmaniasis and HIV infection. J Am Acad Dermatol. 1999;41:847–50.CrossRefPubMed
24.
Zurück zum Zitat Van Grinsven J, Diro E. Visceral leishmaniasis. Infect Dis Clin North Am. 2012;26:309–22.CrossRef Van Grinsven J, Diro E. Visceral leishmaniasis. Infect Dis Clin North Am. 2012;26:309–22.CrossRef
25.
Zurück zum Zitat De Simone C, Amerio P, Amoruso G, Bardazzi F, Campanati A, Conti A, Gisondi P, Gualdi G, Guarneri C, Leoni L, Loconsole F, Mazzotta A, Musumeci ML, Piaserico S, Potenza C, Prestinari F. Immunogenicity of anti-TNFα therapy in psoriasis: a clinical issue? Expert Opin Biol Ther. 2013;13(12):1673–82.CrossRefPubMed De Simone C, Amerio P, Amoruso G, Bardazzi F, Campanati A, Conti A, Gisondi P, Gualdi G, Guarneri C, Leoni L, Loconsole F, Mazzotta A, Musumeci ML, Piaserico S, Potenza C, Prestinari F. Immunogenicity of anti-TNFα therapy in psoriasis: a clinical issue? Expert Opin Biol Ther. 2013;13(12):1673–82.CrossRefPubMed
26.
Zurück zum Zitat Bardazzi F, Amerio P, Amoruso G, Campanati A, Conti A, De Simone C, Gisondi P, Gualdi G, Guarneri C, Loconsole F, Mazzotta A, Musumeci ML, Odorici G, Piaserico S, Potenza C, Scudeller L, Alphard Study Group. Investigating psoriasis awareness among patients in Italy: validation of a questionnaire. Eur Rev Med Pharmacol Sci. 2014;18(22):3435–52.PubMed Bardazzi F, Amerio P, Amoruso G, Campanati A, Conti A, De Simone C, Gisondi P, Gualdi G, Guarneri C, Loconsole F, Mazzotta A, Musumeci ML, Odorici G, Piaserico S, Potenza C, Scudeller L, Alphard Study Group. Investigating psoriasis awareness among patients in Italy: validation of a questionnaire. Eur Rev Med Pharmacol Sci. 2014;18(22):3435–52.PubMed
27.
Zurück zum Zitat Tchernev G, Lotti T, Cardoso JC, Kanazawa N, Guarneri C, Wollina U. Cancer, infection and disturbances of the integrity of tissue homeostasis: the most significant triggers for molecular mimicry and autoimmunity in dermatology? Wien Med Wochenschr. 2014;164(13–14):245–6.CrossRefPubMed Tchernev G, Lotti T, Cardoso JC, Kanazawa N, Guarneri C, Wollina U. Cancer, infection and disturbances of the integrity of tissue homeostasis: the most significant triggers for molecular mimicry and autoimmunity in dermatology? Wien Med Wochenschr. 2014;164(13–14):245–6.CrossRefPubMed
28.
Zurück zum Zitat Guarneri C, Guarneri F, Risitano G, Lentini M, Vaccaro M. Solitary asymptomatic nodule of the great toe. Int J Dermatol. 2005;44(3):245–7.CrossRefPubMed Guarneri C, Guarneri F, Risitano G, Lentini M, Vaccaro M. Solitary asymptomatic nodule of the great toe. Int J Dermatol. 2005;44(3):245–7.CrossRefPubMed
29.
Zurück zum Zitat Borgia F, Guarneri C, Guarneri F, Vaccaro M. Radiation recall dermatitis after docetaxel administration: absolute indication to replace the drug? Br J Dermatol. 2005;153(3):674–5.CrossRefPubMed Borgia F, Guarneri C, Guarneri F, Vaccaro M. Radiation recall dermatitis after docetaxel administration: absolute indication to replace the drug? Br J Dermatol. 2005;153(3):674–5.CrossRefPubMed
30.
Zurück zum Zitat Guarneri C, Cannavò SP. Dermacase. Can you identify this condition? Sarcoidosis. Can Fam Physician. 2012;58(8):859–61.PubMedPubMedCentral Guarneri C, Cannavò SP. Dermacase. Can you identify this condition? Sarcoidosis. Can Fam Physician. 2012;58(8):859–61.PubMedPubMedCentral
31.
Zurück zum Zitat Cannavò SP, Lentini M, Magliolo E, Guarneri C. Cutaneous angiosarcoma of the face. J Eur Acad Dermatol Venereol. 2003;17(5):594–5.CrossRefPubMed Cannavò SP, Lentini M, Magliolo E, Guarneri C. Cutaneous angiosarcoma of the face. J Eur Acad Dermatol Venereol. 2003;17(5):594–5.CrossRefPubMed
32.
Zurück zum Zitat Antinori S, Calattini S, Longhi E, Bestetti G, Piolini R, Magni C, Orlando G, Gramiccia M, Acquaviva V, Foschi A, Corvasce S, Colomba C, Titone L, Parravicini C, Cascio A, Corbellino M. Clinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8‑year experience in Italy and review of the literature. Clin Infect Dis. 2007;44:1602–10.CrossRefPubMed Antinori S, Calattini S, Longhi E, Bestetti G, Piolini R, Magni C, Orlando G, Gramiccia M, Acquaviva V, Foschi A, Corvasce S, Colomba C, Titone L, Parravicini C, Cascio A, Corbellino M. Clinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8‑year experience in Italy and review of the literature. Clin Infect Dis. 2007;44:1602–10.CrossRefPubMed
33.
34.
Zurück zum Zitat Di Masi F, Ursini T, Iannece MD, Chianura L, Baldasso F, Foti G, Di Gregorio P, Casabianca A, Storaci N, Nigro L, Colomba C, Marazzi MG, Todaro G, Tordini G, Zanelli G, Cenderello G, Acone N, Polilli E, Migliore S, Almi P, Pizzigallo E, Sagnelli E, Mazzotta F, Russo R, Manzoli L, Parruti G. Five-year retrospective Italian multicenter study of visceral leishmaniasis treatment. Antimicrob Agents Chemother. 2014;58(1):414–8.CrossRefPubMedPubMedCentral Di Masi F, Ursini T, Iannece MD, Chianura L, Baldasso F, Foti G, Di Gregorio P, Casabianca A, Storaci N, Nigro L, Colomba C, Marazzi MG, Todaro G, Tordini G, Zanelli G, Cenderello G, Acone N, Polilli E, Migliore S, Almi P, Pizzigallo E, Sagnelli E, Mazzotta F, Russo R, Manzoli L, Parruti G. Five-year retrospective Italian multicenter study of visceral leishmaniasis treatment. Antimicrob Agents Chemother. 2014;58(1):414–8.CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat WHO. Report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. Geneva: WHO; 2010. 22–26 March 2010. WHO. Report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. Geneva: WHO; 2010. 22–26 March 2010.
36.
Zurück zum Zitat Allenbach C, Launois P, Mueller C, Tacchini-Cottier F. An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection. Eur J Immunol. 2008;38:720–31.CrossRefPubMed Allenbach C, Launois P, Mueller C, Tacchini-Cottier F. An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection. Eur J Immunol. 2008;38:720–31.CrossRefPubMed
37.
Zurück zum Zitat Sivamani RK, Goodarzi H, Garcia MS, Raychaudhuri SP, Wehrli LN, Ono Y, Maverakis E. Biologic therapies in the treatment of psoriasis: a comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring. Clin Rev Allergy Immunol. 2013 Apr;44(2):121–40. doi:10.1007/s12016-012-8301-7. Review. Sivamani RK, Goodarzi H, Garcia MS, Raychaudhuri SP, Wehrli LN, Ono Y, Maverakis E. Biologic therapies in the treatment of psoriasis: a comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring. Clin Rev Allergy Immunol. 2013 Apr;44(2):121–40. doi:10.​1007/​s12016-012-8301-7. Review.
Metadaten
Titel
Cutaneous and visceral leishmaniasis during anti-TNFα therapy
verfasst von
Claudio Guarneri, M.D.
Valentina Bevelacqua, M.D., Ph.D.
Prof. James W. Patterson, M.D.
Prof. Georgi Tchernev
Publikationsdatum
01.03.2017
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 3-4/2017
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-016-0527-1

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