Malondialdehyde kinetics following coronary artery bypass grafting and its relation to osteopontin
Background: Cardiac surgery is associated with inflammation and oxidative stress; malondialdehyde (MDA) is a marker of oxidative stress and osteopontin (OPN) is a proinflammatory cytokine. We studied MDA kinetics following coronary artery bypass grafting (CABG) and its relation to OPN.
Methods: We evaluated 50 consecutive patients (60 ± 10 year-old, 44 men and 6 women) with stable coronary artery disease and left ventricular ejection fraction of 50 ± 8 % undergoing elective CABG on pump. Peripheral plasma samples were drawn at baseline, 24 and 72 h postoperatively. OPN was evaluated at baseline and MDA and cardiac enzymes at all time points.
Results: MDA levels increased significantly at 72 h postoperative compared with preoperative and 24 h postoperative levels whereas there was no difference between the pre and first postoperative values (p = 0.67). MDA change was positively correlated with the change in troponin at baseline and at 72 h (r = 0.6, p = 0.022) as well as with preoperative OPN levels (r = 0.28, p = 0.047). There was a significant positive correlation between MDA at 72 h and age (r = 0.27, p = 0.039). In addition, MDA change differed significantly in relation to diabetes at baseline and at 72 h—2.99 (4.77) in diabetics versus 0.69 (3.82) in non-diabetics (p = 0.05).
Conclusions: MDA increases post on-pump CABG but only at 72 h and this increase correlates with preoperative OPN levels. In addition, MDA increase is related to age and diabetes as well as troponin increase following surgery.