Poor sensitivity of 99mTc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis
Background: Ubiquicidin 29–41 (UBI) is an antimicrobial peptide.
Methods: In total eight men and two women with high probability of acute appendicitis were serially imaged for up to 30 min after the intravenous administration of 370 MBq of 99mTc-UBI, before surgical exploration
Results: The scan showed mild to moderate increased uptake in the right lower quadrant in six patients. Quantitative analysis failed to show any difference between suppurative and gangrenous appendicitis.
Conclusion: 99mTc-UBI scintigraphy has 20 % sensitivity for diagnosis of acute appendicitis.