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Erschienen in: Wiener klinische Wochenschrift 15-16/2016

01.08.2016 | original article

Can we improve the therapy of Clostridium difficile infection in elderly patients?

verfasst von: Katarina Bielakova, MD, PhD, Emmanuela Fernandova, MD, Prof. Hana Matejovska-Kubesova, MD, PhD, Prof. Pavel Weber, MD, PhD, Dana Prudius, MD, Josef Bednar, Ing, PhD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2016

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Summary

Background

Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI.

Methods

In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013. The examined group comprised 148 women (63 %) and 87 men (37 %). For the diagnosis of CDI, confirmation of A and B toxins in the patients’ stool or an autopsy confirmation was crucial.

Results

The impact of antibiotic therapy on the increased incidence of CDI was clearly confirmed in our study group when examining patients’ histories. Other risk factors included cerebrovascular disease, dementia, the presence of pressure ulcers, and immobility. Our new model consisted of a combination of the following parameters: the number of antibiotics used (from patients’ history), nutritional status (Mini Nutritional Assessment short-form test), presence of pressure ulcers, and occurrence of fever.

Conclusion

Our logistic regression model may predict mortality in geriatric patients suffering from CDI. This could help improve the therapeutic process.
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Metadaten
Titel
Can we improve the therapy of Clostridium difficile infection in elderly patients?
verfasst von
Katarina Bielakova, MD, PhD
Emmanuela Fernandova, MD
Prof. Hana Matejovska-Kubesova, MD, PhD
Prof. Pavel Weber, MD, PhD
Dana Prudius, MD
Josef Bednar, Ing, PhD
Publikationsdatum
01.08.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1056-z

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