nach oben

Erschienen in:

01.04.2015 | original article

Diffusion-weighted MRI in the differential diagnosis of uterine endometrial cavity tumors

verfasst von: Asst. Prof. Omer Karakas, Asst. Prof. Dr. Ekrem Karakas, Ferit Dogan, MD, Nihat Kilicaslan, MD, Asst. Prof. Aysun Camuzcuoglu, Asst. Prof. Adnan Incebiyik, Asst. Prof. Hakan Camuzcuoglu

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2015

Einloggen, um Zugang zu erhalten

Summary

Background

This study aimed to investigate the efficacy of quantitative apparent diffusion coefficient (ADC) measurement in the differential diagnosis of the uterine endometrial cavity tumors (UECT).

Methods

This study included consecutive 36 female patients with UECT. The groups were formed as follows: group 1, patients with endometrial carcinoma; group 2, patients with endometrial polyp; group 3, patients with submucosal leiomyoma; and additionally group A, patients with malignant lesion; group B patients with benign lesion. Tumoral and outer myometrial ADC values were measured and the tumor–myometrium ADC ratios were calculated in all patients. Kolmogorov–Smirnov tests were used to test the normality of the data distributions. The data were not normally distributed, and therefore, nonparametric tests were performed. The cut-off values, sensitivity, and specificity were determined by the receiver operating characteristic analysis.

Results

The mean ADC value and ratio of group 1 were lower than that of group 2 and 3, and the mean ADC value and ratio of group 3 were lower than that of group 2. The sensitivity and specificity for group 1, 2, and 3 were as follows: 90, 100, and 66.7 %; and 81.8, 88, and 58.8 %, respectively, in terms of the ADC values; 90, 100 and 67 %; and 77.3, 96, and 64.7 % in terms of the ADC ratios. Statistically significant differences were demonstrated between group A and B in terms of mean tumoral ADC values and ratios. Sensitivity and specificity were found to be 90 and 81.8 %, respectively, in terms of the ADC values. The sensitivity and specificity were found to be 90 and 77.3 %, respectively, in terms of the ADC ratios.

Conclusions

ADC values and ratios represent a promising parameter in the determination of the tumoral lesions in patients with UECT.

Vorheriger Artikel Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis?

Nächster Artikel Use of PET-CT for the assessment of treatment results in patients with sarcoidosis

Takeuchi M, Matsuzaki K, Uehara H, Yoshida S, Nishitani H, Shimazu H. Pathologies of the uterine endometrial cavity: usual and unusual manifestations and pitfalls on magnetic resonance. Eur Radiol. 2005;15(11):2244–55.CrossRefPubMed

Aubé C, Racineux PX, Lebigot J, et al. [Diagnosis and quantification of hepatic fibrosis with diffusion weighted MR imaging: preliminary results]. J Radiol. 2004;85(3):301–6.CrossRefPubMed

Fujii S, Matsusue E, Kigawa J, et al. Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol. 2008;18(2):384–9.CrossRefPubMed

Tong DC, Albers GW. Diffusion and perfusion magnetic resonance imaging for the evaluation of acute stroke: potential use in guiding thrombolytic therapy. Curr Opin Neurol. 2000;13(1):45–50.CrossRefPubMed

Guo Y, Cai YQ, Cai ZL, et al. Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging. J Magn Reson Imaging. 2002;16(2):172–8.CrossRefPubMed

Woodhams R, Matsunaga K, Kan S, et al. ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci. 2005;4(1):35–42.CrossRefPubMed

Rubesova E, Grell AS, De Maertelaer V, Metens T, Chao SL, Lemort M. Quantitative diffusion imaging in breast cancer: a clinical prospective study. J Magn Reson Imaging. 2006;24(2):319–24.CrossRefPubMed

Patel J, Sigmund EE, Rusinke H, Oei M, Babbs JS, Taouli B. Diagnosis of cirrhosis with intravoxel incoherent motion diffusion MRI and dynamic contrast-enhanced MRI alone and in combination: preliminary experience. J Magn Reson Imaging. 2010;31(3):589–600.CrossRefPubMed

Sener RN. Diffusion MRI: apparent diffusion coefficient (ADC) values in the normal brain, and a classification of brain disorders based on ADC values. Comput Med Imaging Graph. 2001;25(4):299–326.CrossRefPubMed

10.

Mukherji SK, Chenevert TL, Castillo M. Diffusion-weighted magnetic resonance imaging. J Neuroophthalmol. 2002;22(2):118–22.CrossRefPubMed

11.

Sugahara T, Korogi Y, Kochi M, et al. Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging. 1999;9(1):53–60.CrossRefPubMed

12.

Gauvain KM, McKinstry RC, Mukherjee P, et al. Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol. 2001;177(2):449–54.CrossRefPubMed

13.

Guo AC, Cummings TJ, Dash RC, Provenzale JM. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology. 2002;224(1):177–83.CrossRefPubMed

14.

Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo M. Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol. 2006;27(6):1362–9.PubMed

15.

Hayashida Y, Hirai T, Morishita S, et al. Diffusion-weighted imaging of metastatic brain tumors: comparison with histologic type and tumor cellularity. AJNR Am J Neuroradiol. 2006;27(7):1419–25.PubMed

16.

Silverberg SG, Kurman RJ. Tumors of the uterine corpus and gestational disease. In: Rosai J, Aovin trophoblastic L, editors. Atlas of tumor pathology. Vol. 3. Washington DC: Armed Forces Institute of Pathology; 2002. pp. 113–51.

17.

Shimada K, Ohashi I, Kasahara I, et al. Differentiation between completely hyalinized uterine leiomyomas and ordinary leiomyomas: three-phase dynamicmagnetic resonance imaging (MRI) vs. diffusion-weighted MRI with very small b-factors. J Magn Reson Imaging. 2004;20(1):97–104.CrossRefPubMed

18.

Liapi E, Kamel IR, Bluemke DA, Jacobs MA, Kim HS. Assessment of response of uterine fibroids and myometrium to embolization using diffusion-weighted echoplanar MR imaging. J Comput Assist Tomogr. 2005;29(1):83–6.CrossRefPubMed

Titel: Diffusion-weighted MRI in the differential diagnosis of uterine endometrial cavity tumors
verfasst von: Asst. Prof. Omer Karakas
Asst. Prof. Dr. Ekrem Karakas
Ferit Dogan, MD
Nihat Kilicaslan, MD
Asst. Prof. Aysun Camuzcuoglu
Asst. Prof. Adnan Incebiyik
Asst. Prof. Hakan Camuzcuoglu
Publikationsdatum: 01.04.2015
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 7-8/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-015-0709-7

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7-8/2015

Clinical profile, natural history, and predictors of mortality in patients with acute-on-chronic liver failure (ACLF)

Researcher of the month

Complete rupture of the right upper lobe bronchus due to blunt thoracic trauma

Time: an underestimated variable in minimizing the gender gap in medical college admission scores

N-acetylcysteine in patients with COPD exacerbations associated with increased sputum

On the significance of elektroconvulsive therapy in the treatment of severe mental diseases