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memo - Magazine of European Medical Oncology

Erschienen in:

01.04.2015 | short review

Clinical update: B-cell receptor kinase inhibitors in chronic lymphocytic leukemia

verfasst von: Lukas Weiss, MD, PhD, Thomas Melchardt, MD, Alexander Egle, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 1/2015

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Abstract

B-cell receptor (BCR) inhibitors represent an exciting new treatment modality in chronic lymphocytic leukemia (CLL). Currently, ibrutinib monotherapy as well as idelalisib in combination with rituximab are approved by the European Medical Agency for the treatment of all patients with relapsed/refractory CLL and for first-line treatment of patients with deletion 17p or TP53 mutation unsuitable for chemoimmunotherapy. The results of ongoing trials with these and other BCR inhibitors are expected to lay the basis for approval in further indications, but have to be awaited. Above all, BCR inhibitors have shown to be able to fill the gap of urgently needed therapies for the elderly and comorbid CLL patient as well as the CLL patient with deletion 17p. BCR inhibitors might also challenge the role of allogeneic stem cell transplantation in CLL in the future.

Vorheriger Artikel High-dose chemotherapy and autologous hematopoietic stem cell transplantation in a myeloma patient with terminal renal failure and hepatitis C with high viral load

Nächster Artikel PET in lymphoma: who, when, how often, pitfalls?

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Titel: Clinical update: B-cell receptor kinase inhibitors in chronic lymphocytic leukemia
verfasst von: Lukas Weiss, MD, PhD
Thomas Melchardt, MD
Alexander Egle, MD
Publikationsdatum: 01.04.2015
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 1/2015
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-014-0186-0

Springer Medizin Österreich

Abstract

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