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Erschienen in: Wiener klinische Wochenschrift 21-22/2014

01.11.2014 | original article

Serum H-FABP levels in patients with hypothyroidism

verfasst von: Fahri Gunes, Mehmet Asik, Ahmet Temiz, Ahmet Vural, Hacer Sen, Emine Binnetoglu, Neslihan Bozkurt, Zeliha Tekeli, Gokhan Erbag, Kubilay Ukinc, Erdem Akbal

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2014

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Summary

Objective

Hypothyroidism (HT) has an increased risk for cardiovascular mortality and morbidity due to increased atherosclerosis. Heart-type fatty acid binding protein (H-FABP) is abundant in the cytosol of cardiomyocytes, and transports fatty acids into these cells. Although H-FABP has been shown to increase in several atherosclerotic and inflammatory conditions, there is no literature data indicating an alteration in other atherosclerotic processes such as HT.

Material and methods

A total of 39 patients with subclinical hypothyroidism (SCH), 26 patients with overt hypothyroidism (OH), and 29 healthy subjects were enrolled in this study. Carotid artery intima media thickness (CIMT) was measured by high resolution B mode ultrasonography. H-FABP levels, thyroid function test, and biochemical tests of all subjects were measured. The associations between H-FABP and thyroid test and CIMT were examined with correlation and regression analysis.

Results

OH patients had higher H-FABP levels (mean, 6.18 ± 3.08 ng/mL) than both the SCH (mean, 3.81 ± 2.16 ng/mL) and the controls (mean, 2.12 ± 1.27 ng/mL) (P < 0.01 and < 0.001, respectively). SCH patients had increased serum H-FABP levels compared with control subjects (P < 0.01). CIMT of both OH and SCH patients was also significantly greater compared with control subjects (both of p < 0.01). H-FABP was significantly and positively correlated with age, systolic blood pressure, thyroid stimulating hormone (TSH) levels, and CIMT, and negatively correlated with fT4 levels. The H-FABP levels retained an independent and positive association with systolic blood pressure, and a negative association with fT4 levels.

Conclusion

Serum H-FABP levels progressively increased from the control group to the OH group. This suggests that H-FABP may be an indicator of low-level myocardial damage in HT, especially when used together with CIMT. Decreasing serum fT4 levels seem also to have an effect on H-FABP levels.
Literatur
1.
Zurück zum Zitat Müller B, Tsakiris DA, Roth CB, Guglielmetti M, Staub JJ, Marbet GA. Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease. Eur J Clin Invest. 2001;31:131–7.PubMedCrossRef Müller B, Tsakiris DA, Roth CB, Guglielmetti M, Staub JJ, Marbet GA. Haemostatic profile in hypothyroidism as potential risk factor for vascular or thrombotic disease. Eur J Clin Invest. 2001;31:131–7.PubMedCrossRef
2.
Zurück zum Zitat Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study. Ann Intern Med. 2000;132:270–8.PubMedCrossRef Hak AE, Pols HA, Visser TJ, Drexhage HA, Hofman A, Witteman JC. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam study. Ann Intern Med. 2000;132:270–8.PubMedCrossRef
3.
Zurück zum Zitat Tseng FY, Lin WY, Lin CC, Lee LT, Li TC, Sung PK, Huang KC. Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol. 2012;60:730–7.PubMedCrossRef Tseng FY, Lin WY, Lin CC, Lee LT, Li TC, Sung PK, Huang KC. Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults. J Am Coll Cardiol. 2012;60:730–7.PubMedCrossRef
4.
Zurück zum Zitat Schultz M, Kistorp C, Raymond I, Dimsits J, Tuxen C, Hildebrandt P, Faber J. Cardiovascular events in thyroid disease: a population based, prospective study. Horm Metab Res. 2011;43:653–9.PubMedCrossRef Schultz M, Kistorp C, Raymond I, Dimsits J, Tuxen C, Hildebrandt P, Faber J. Cardiovascular events in thyroid disease: a population based, prospective study. Horm Metab Res. 2011;43:653–9.PubMedCrossRef
5.
Zurück zum Zitat Riggs JE. Acute exertional rhabdomyolysis in hypothyroidism: the result of a reversible defect in glycogenolysis? Mil Med. 1990;155:71. Riggs JE. Acute exertional rhabdomyolysis in hypothyroidism: the result of a reversible defect in glycogenolysis? Mil Med. 1990;155:71.
6.
Zurück zum Zitat Sekine N, Yamamoto M, Michikawa M, Enomoto T, Hayashi M, Ozawa E, Kobayashi T. Rhabdomyolysis and acute renal failure in a patient with hypothyroidism. Intern Med. 1993;32:269.PubMedCrossRef Sekine N, Yamamoto M, Michikawa M, Enomoto T, Hayashi M, Ozawa E, Kobayashi T. Rhabdomyolysis and acute renal failure in a patient with hypothyroidism. Intern Med. 1993;32:269.PubMedCrossRef
7.
Zurück zum Zitat Pasqualetti G, Tognini S, Polini A, Caraccio N, Monzani F. Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? J Clin Endocrinol Metab. 2013;98:2256–66.PubMedCrossRef Pasqualetti G, Tognini S, Polini A, Caraccio N, Monzani F. Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? J Clin Endocrinol Metab. 2013;98:2256–66.PubMedCrossRef
8.
Zurück zum Zitat Asik M, Sahin S, Ozkul F, Anaforoglu I, Ayhan S, Karagol S, Gunes F, Algun E. Evaluation of epicardial fat tissue thickness in patients with Hashimoto Thyroiditis. Clin Endocrinol. 2013;79:571–6.CrossRef Asik M, Sahin S, Ozkul F, Anaforoglu I, Ayhan S, Karagol S, Gunes F, Algun E. Evaluation of epicardial fat tissue thickness in patients with Hashimoto Thyroiditis. Clin Endocrinol. 2013;79:571–6.CrossRef
9.
Zurück zum Zitat Ashrafian H, Lim TK, Senior R. Carotid ultrasound imaging: an effective technique for detecting early atherosclerosis-vascular screening for cardiovascular disease has come of age. Am Soc Echocardiogr. 2007;20:1–3.CrossRef Ashrafian H, Lim TK, Senior R. Carotid ultrasound imaging: an effective technique for detecting early atherosclerosis-vascular screening for cardiovascular disease has come of age. Am Soc Echocardiogr. 2007;20:1–3.CrossRef
10.
Zurück zum Zitat Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino RB Sr. Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med. 2011;365:213–21.PubMedCentralPubMedCrossRef Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino RB Sr. Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med. 2011;365:213–21.PubMedCentralPubMedCrossRef
11.
Zurück zum Zitat Akbal E, Özbek M, Güneş F, Akyürek Ö, Üreten K, Delibaşı T. Serum heart type fatty acid binding protein levels in metabolic syndrome. Endocrine. 2009;36:433–7.PubMedCrossRef Akbal E, Özbek M, Güneş F, Akyürek Ö, Üreten K, Delibaşı T. Serum heart type fatty acid binding protein levels in metabolic syndrome. Endocrine. 2009;36:433–7.PubMedCrossRef
12.
Zurück zum Zitat Narumi T, Shishido T, Kiribayashi N, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Shibata Y, Konta T, Ueno Y, Kato T, Kayama T, Kubota I. Impact of insulin resistance on silent and ongoing myocardial damage in normal subjects: the Takahata study. Exp Diabetes Res. 2012;2012:815098.PubMedCentralPubMedCrossRef Narumi T, Shishido T, Kiribayashi N, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Shibata Y, Konta T, Ueno Y, Kato T, Kayama T, Kubota I. Impact of insulin resistance on silent and ongoing myocardial damage in normal subjects: the Takahata study. Exp Diabetes Res. 2012;2012:815098.PubMedCentralPubMedCrossRef
13.
Zurück zum Zitat Kume N, Mitsuoka H, Hayashida K, Tanaka M. Pentraxin 3 as a biomarker for acute coronary syndrome: comparison with biomarkers for cardiac damage. J Cardiol. 2011;58:38–45.PubMedCrossRef Kume N, Mitsuoka H, Hayashida K, Tanaka M. Pentraxin 3 as a biomarker for acute coronary syndrome: comparison with biomarkers for cardiac damage. J Cardiol. 2011;58:38–45.PubMedCrossRef
14.
Zurück zum Zitat Başar O, Akbal E, Köklü S, Tuna Y, Koçak E, Başar N, Tok D, Erbiş H, Senes M. Increased H-FABP concentrations in nonalcoholic fatty liver disease. Possible marker for subclinical myocardial damage and subclinical atherosclerosis. Herz. 2013;38:417–22.PubMedCrossRef Başar O, Akbal E, Köklü S, Tuna Y, Koçak E, Başar N, Tok D, Erbiş H, Senes M. Increased H-FABP concentrations in nonalcoholic fatty liver disease. Possible marker for subclinical myocardial damage and subclinical atherosclerosis. Herz. 2013;38:417–22.PubMedCrossRef
15.
Zurück zum Zitat Fournier NC, Richard MA. Role of fatty acid-binding protein in cardiac fatty acid oxidation. Mol Cell Biochem. 1990;98:149–59.PubMedCrossRef Fournier NC, Richard MA. Role of fatty acid-binding protein in cardiac fatty acid oxidation. Mol Cell Biochem. 1990;98:149–59.PubMedCrossRef
16.
Zurück zum Zitat Reiter M, Twerenbold R, Reichlin T, Mueller M, Hoeller R, Moehring B, Haaf P, Wildi K, Merk S, Bernhard D, Mueller CZ, Freese M, Freidank H, Campodarve Botet I, Mueller C. Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction. Heart. 2013;99:708–14.PubMedCrossRef Reiter M, Twerenbold R, Reichlin T, Mueller M, Hoeller R, Moehring B, Haaf P, Wildi K, Merk S, Bernhard D, Mueller CZ, Freese M, Freidank H, Campodarve Botet I, Mueller C. Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction. Heart. 2013;99:708–14.PubMedCrossRef
17.
Zurück zum Zitat Kleine AH, Glatz JF, Van Nieuwenhoven FA, Van der Vusse GJ. Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man. Mol Cell Biochem. 1992;116:155–62.PubMedCrossRef Kleine AH, Glatz JF, Van Nieuwenhoven FA, Van der Vusse GJ. Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man. Mol Cell Biochem. 1992;116:155–62.PubMedCrossRef
18.
Zurück zum Zitat Bass NM. The cellular fatty acid binding proteins: aspects of structure, regulation, and function. Int Rev Cytol. 1988;111:143–84.PubMedCrossRef Bass NM. The cellular fatty acid binding proteins: aspects of structure, regulation, and function. Int Rev Cytol. 1988;111:143–84.PubMedCrossRef
19.
Zurück zum Zitat Dinh W, Nickl W, Füth R, Lankisch M, Hess G, Zdunek D, Scheffold T, Barroso MC, Tiroch K, Ziegler D, Seyfarth M. High sensitive troponin T and heart fatty acid binding protein: novel biomarker in heart failure with normal ejection fraction? A cross-sectional study. BMC Cardiovasc Disord. 2011;11:41.PubMedCentralPubMedCrossRef Dinh W, Nickl W, Füth R, Lankisch M, Hess G, Zdunek D, Scheffold T, Barroso MC, Tiroch K, Ziegler D, Seyfarth M. High sensitive troponin T and heart fatty acid binding protein: novel biomarker in heart failure with normal ejection fraction? A cross-sectional study. BMC Cardiovasc Disord. 2011;11:41.PubMedCentralPubMedCrossRef
20.
Zurück zum Zitat Pelsers MM, Hermens WT, Glatz JF. Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta. 2005;352:15–35.PubMedCrossRef Pelsers MM, Hermens WT, Glatz JF. Fatty acid-binding proteins as plasma markers of tissue injury. Clin Chim Acta. 2005;352:15–35.PubMedCrossRef
21.
Zurück zum Zitat Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metabolism. 2003;88:2438–44.CrossRef Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metabolism. 2003;88:2438–44.CrossRef
22.
Zurück zum Zitat Bamashmoos SA, Al-Nuzaily MA, Al-Meeri AM, Ali FH. Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients. Springerplus. 2013;2:423.PubMedCentralPubMedCrossRef Bamashmoos SA, Al-Nuzaily MA, Al-Meeri AM, Ali FH. Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients. Springerplus. 2013;2:423.PubMedCentralPubMedCrossRef
23.
Zurück zum Zitat Owen PJ, Rajiv C, Vinereanu D, Mathew T, Fraser AG, Lazarus JH. Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. J Clin Endocrinol Metab. 2006;9:2126–32.CrossRef Owen PJ, Rajiv C, Vinereanu D, Mathew T, Fraser AG, Lazarus JH. Subclinical hypothyroidism, arterial stiffness, and myocardial reserve. J Clin Endocrinol Metab. 2006;9:2126–32.CrossRef
24.
Zurück zum Zitat Gunduz M, Gunduz E, Kircelli F, Okur N, Ozkaya M. Role of surrogate markers of atherosclerosis in clinical and subclinical thyroidism. Int J Endocrinol. 2012;2012:109797.PubMedCentralPubMed Gunduz M, Gunduz E, Kircelli F, Okur N, Ozkaya M. Role of surrogate markers of atherosclerosis in clinical and subclinical thyroidism. Int J Endocrinol. 2012;2012:109797.PubMedCentralPubMed
25.
Zurück zum Zitat Dullaart RP, de Vries R, Roozendaal C, Kobold AC, Sluiter WJ. Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects. Clin Endocrinol. 2007;67:668–73.CrossRef Dullaart RP, de Vries R, Roozendaal C, Kobold AC, Sluiter WJ. Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects. Clin Endocrinol. 2007;67:668–73.CrossRef
26.
Zurück zum Zitat Teixeira PF, Reuters VS, Ferreira MM, Almeida CP, Reis FA, Melo BA, Buescu A, Costa AJ, Vaisman M. Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blindclinical trial. Horm Metab Res. 2008;40:50–5. Teixeira PF, Reuters VS, Ferreira MM, Almeida CP, Reis FA, Melo BA, Buescu A, Costa AJ, Vaisman M. Treatment of subclinical hypothyroidism reduces atherogenic lipid levels in a placebo-controlled double-blindclinical trial. Horm Metab Res. 2008;40:50–5.
27.
Zurück zum Zitat Celi FS, Zemskova M, Linderman JD, Smith S, Drinkard B, Sachdev V, Skarulis MC, Kozlosky M, Csako G, Costello R, Pucino F. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab. 2011;96:3466–74.PubMedCentralPubMedCrossRef Celi FS, Zemskova M, Linderman JD, Smith S, Drinkard B, Sachdev V, Skarulis MC, Kozlosky M, Csako G, Costello R, Pucino F. Metabolic effects of liothyronine therapy in hypothyroidism: a randomized, double-blind, crossover trial of liothyronine versus levothyroxine. J Clin Endocrinol Metab. 2011;96:3466–74.PubMedCentralPubMedCrossRef
28.
Zurück zum Zitat Knapp M, Lisowska A, Sobkowicz B, Tycińska A, Sawicki R, Musiał WJ. Myocardial perfusion and intima-media thickness in patients with subclinical hypothyroidism. Adv Med Sci. 2013;5:44–9.CrossRef Knapp M, Lisowska A, Sobkowicz B, Tycińska A, Sawicki R, Musiał WJ. Myocardial perfusion and intima-media thickness in patients with subclinical hypothyroidism. Adv Med Sci. 2013;5:44–9.CrossRef
29.
Zurück zum Zitat Sun YP, Wang WD, Ma SC, Wang LY, Qiao LY, Zhang LP. [Changes of heart-type fatty acid-binding protein in children with chronic heart failure and its significance]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:99–101.PubMed Sun YP, Wang WD, Ma SC, Wang LY, Qiao LY, Zhang LP. [Changes of heart-type fatty acid-binding protein in children with chronic heart failure and its significance]. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15:99–101.PubMed
30.
Zurück zum Zitat Komamura K, Sasaki T, Hanatani A, Kim J, Hashimura K, Ishida Y, Ohkaru Y, Asayama K, Tanaka T, Ogai A, Nakatani T, Kitamura S, Kangawa K, Miyatake K, Kitakaze M. Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. Heart. 2006;92:615–8.PubMedCentralPubMedCrossRef Komamura K, Sasaki T, Hanatani A, Kim J, Hashimura K, Ishida Y, Ohkaru Y, Asayama K, Tanaka T, Ogai A, Nakatani T, Kitamura S, Kangawa K, Miyatake K, Kitakaze M. Heart-type fatty acid binding protein is a novel prognostic marker in patients with non-ischaemic dilated cardiomyopathy. Heart. 2006;92:615–8.PubMedCentralPubMedCrossRef
31.
Zurück zum Zitat Schaap FG, Van der Vusse GJ, Glatz JF. Fatty acid-binding proteins in the heart. Mol Cell Biochem. 1998;180:43–51.PubMedCrossRef Schaap FG, Van der Vusse GJ, Glatz JF. Fatty acid-binding proteins in the heart. Mol Cell Biochem. 1998;180:43–51.PubMedCrossRef
32.
Zurück zum Zitat Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, Watanabe T, Nitobe J, Harada M, Suzuki S, Koyama Y, Kitahara T, Sasaki T, Kubota I. Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients. J Card Fail. 2007;13:120–7.PubMedCrossRef Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, Watanabe T, Nitobe J, Harada M, Suzuki S, Koyama Y, Kitahara T, Sasaki T, Kubota I. Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients. J Card Fail. 2007;13:120–7.PubMedCrossRef
33.
Zurück zum Zitat Ishino M, Takeishi Y, Niizeki T, Watanabe T, Nitobe J, Miyamoto T, Miyashita T, Kitahara T, Suzuki S, Sasaki T, Bilim O, Kubota I. Risk stratification of chronic heart failure patients by multiple biomarkers: implications of BNP, H-FABP, and PTX3. Circ J. 2008;72:1800–5.PubMedCrossRef Ishino M, Takeishi Y, Niizeki T, Watanabe T, Nitobe J, Miyamoto T, Miyashita T, Kitahara T, Suzuki S, Sasaki T, Bilim O, Kubota I. Risk stratification of chronic heart failure patients by multiple biomarkers: implications of BNP, H-FABP, and PTX3. Circ J. 2008;72:1800–5.PubMedCrossRef
34.
Zurück zum Zitat Arimoto T, Takeishi Y, Shiga R, Fukui A, Tachibana H, Nozaki N, Hirono O, Nitobe J, Miyamoto T, Hoit BD, Kubota I. Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure. J Card Fail. 2005;11:56–60.PubMedCrossRef Arimoto T, Takeishi Y, Shiga R, Fukui A, Tachibana H, Nozaki N, Hirono O, Nitobe J, Miyamoto T, Hoit BD, Kubota I. Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure. J Card Fail. 2005;11:56–60.PubMedCrossRef
Metadaten
Titel
Serum H-FABP levels in patients with hypothyroidism
verfasst von
Fahri Gunes
Mehmet Asik
Ahmet Temiz
Ahmet Vural
Hacer Sen
Emine Binnetoglu
Neslihan Bozkurt
Zeliha Tekeli
Gokhan Erbag
Kubilay Ukinc
Erdem Akbal
Publikationsdatum
01.11.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0612-7

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