Skip to main content
Erschienen in: Wiener klinische Wochenschrift 15-16/2014

01.08.2014 | original article

Evaluation of epicardial fat tissue thickness in patients with hyperthyroidism

verfasst von: Assist. Prof. Dr. Emine Binnetoğlu, MD, Assist. Prof. Dr. Mehmet Asik, Assist. Prof. Dr. Burak Altun, Assist. Prof. Dr. Hacer Sen, Assist. Prof. Dr. Emine Gazi, Assist. Prof. Dr. Gökhan Erbağ, Assist. Prof. Dr. Fahri Günes, Assist. Dr. Yıldız Garip Bilen, Assist. Prof. Dr. Ahmet Temiz, Assist. Prof. Dr. Ahmet Barutçu, Assist. Prof. Dr. Adem Bekler

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2014

Einloggen, um Zugang zu erhalten

Summary

Background

Thyroid hormones have several effects on the cardiovascular system, and recent studies have found that thyroid disorders affect coronary intima-media thickness (CIMT) in particular. Despite increased CIMT in patients with hyperthyroidism, the extent of the relationship between CIMT and epicardial fat thickness (EFT) in those patients is unknown. Furthermore, there is no report evaluating the relationship between EFT and overt hyperthyroidism (OH) in the literature. In this study, we aim to evaluate the effectiveness of EFT in predicting atherosclerosis as well as CIMT in patients with OH.

Methods

A total of 30 newly diagnosed, untreated overt hyperthyroid patients and 44 control subjects were included in the study. EFT was measured using a commercially available echocardiography machine (VIVID 7; General Electric Medical Systems, Norway) with a 2.5-MHz probe. The echo-free space between the visceral and parietal pericardium on the anterior wall of the right ventricle was diagnosed as EFT. A linear-array imaging probe of the same echocardiography probe was used to evaluate the CIMT of the right common carotid artery.

Results

The hyperthyroid patients had a significantly greater EFT (mean: 4.31 ± 1.12 mm) than the healthy subjects (mean: 3.11 ± 0.84 mm; p < 0.001). CIMT was also significantly greater in the hyperthyroid patients (mean: 0.62 ± 0.17 mm) than in the healthy subjects (mean: 0.50 ± 0.11 mm; p < 0.01).

Conclusion

In conclusion, the present study shows that mean EFT and CIMT were significantly higher in OH patients, irrespective of confounding factors such as hypertension.
Literatur
1.
2.
Zurück zum Zitat Bahn Chair RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593–646. Bahn Chair RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593–646.
3.
Zurück zum Zitat Dörr M, Wolff B, Robinson DM, et al. The association of thyroid function with cardiac mass and left ventricular hypertrophy. J Clin Endocrinol Metab. 2005;90(2):673–7. Dörr M, Wolff B, Robinson DM, et al. The association of thyroid function with cardiac mass and left ventricular hypertrophy. J Clin Endocrinol Metab. 2005;90(2):673–7.
4.
Zurück zum Zitat Bilir C, Gökosmanoglu F, Caliskan M, Cinemre H, Akdemir R. Regression of the carotid intima media thickness by propylthiouracil therapy in Graves’ hyperthyroidism. Am J Med Sci. 2012;343(4):273–6.PubMedCrossRef Bilir C, Gökosmanoglu F, Caliskan M, Cinemre H, Akdemir R. Regression of the carotid intima media thickness by propylthiouracil therapy in Graves’ hyperthyroidism. Am J Med Sci. 2012;343(4):273–6.PubMedCrossRef
5.
Zurück zum Zitat Şengül C, Özveren O. Epicardial adipose tissue: a review of physiology, pathophysiology, and applications. Anadolu Kardiyol Derg. 2013;13(3):261–5.PubMed Şengül C, Özveren O. Epicardial adipose tissue: a review of physiology, pathophysiology, and applications. Anadolu Kardiyol Derg. 2013;13(3):261–5.PubMed
6.
Zurück zum Zitat Franklyn JA, Maisonneuve P, Sheppard MC, Betteridge J, Boyle P. Mortality after the treatment of hyperthyroidism with radioactive iodine. N Engl J Med. 1998;338(11):712–8.PubMedCrossRef Franklyn JA, Maisonneuve P, Sheppard MC, Betteridge J, Boyle P. Mortality after the treatment of hyperthyroidism with radioactive iodine. N Engl J Med. 1998;338(11):712–8.PubMedCrossRef
7.
Zurück zum Zitat Osman F, Gammage MD, Franklyn JA. Hyperthyroidism and cardiovascular morbidity and mortality. Thyroid. 2002;12(6):483–7.PubMedCrossRef Osman F, Gammage MD, Franklyn JA. Hyperthyroidism and cardiovascular morbidity and mortality. Thyroid. 2002;12(6):483–7.PubMedCrossRef
8.
Zurück zum Zitat Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001;344(7):501–9.PubMedCrossRef Klein I, Ojamaa K. Thyroid hormone and the cardiovascular system. N Engl J Med. 2001;344(7):501–9.PubMedCrossRef
9.
Zurück zum Zitat Kablak-Ziembicka A, Tracz W, Przewlocki T, Pieniazek P, Sokolowski A, Konieczynska M. Association of increased carotid intima-media thickness with the extent of coronary artery disease. Heart. 2004;90(11):1286–90.PubMedCentralPubMedCrossRef Kablak-Ziembicka A, Tracz W, Przewlocki T, Pieniazek P, Sokolowski A, Konieczynska M. Association of increased carotid intima-media thickness with the extent of coronary artery disease. Heart. 2004;90(11):1286–90.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Holaj R, Spacil J, Petrasek J, Malik J, Haas T, Aschermann M. Intima-media thickness of the common carotid artery is the significant predictor of angiographically proven coronary artery disease. Can J Cardiol. 2003;19(6):670–6.PubMed Holaj R, Spacil J, Petrasek J, Malik J, Haas T, Aschermann M. Intima-media thickness of the common carotid artery is the significant predictor of angiographically proven coronary artery disease. Can J Cardiol. 2003;19(6):670–6.PubMed
11.
Zurück zum Zitat Völzke H, Robinson DM, Schminke U, et al. Thyroid function and carotid wall thickness. J Clin Endocrinol Metab. 2004;89(5):2145–9.PubMedCrossRef Völzke H, Robinson DM, Schminke U, et al. Thyroid function and carotid wall thickness. J Clin Endocrinol Metab. 2004;89(5):2145–9.PubMedCrossRef
12.
Zurück zum Zitat Gunduz M, Gunduz E, Kircelli F, Okur N, Ozkaya M. Role of surrogate markers of atherosclerosis in clinical and subclinical thyroidism. Int J Endocrinol. 2012;2012:109797. doi:10.1155/2012/109797. Gunduz M, Gunduz E, Kircelli F, Okur N, Ozkaya M. Role of surrogate markers of atherosclerosis in clinical and subclinical thyroidism. Int J Endocrinol. 2012;2012:109797. doi:10.1155/2012/109797.
13.
Zurück zum Zitat Djaberi R, Schuijf JD, Van Werkhoven JM, et al. Relation of epicardial adipose tissue to coronary atherosclerosis. Am J Cardiol. 2008;102:1602–7.PubMedCrossRef Djaberi R, Schuijf JD, Van Werkhoven JM, et al. Relation of epicardial adipose tissue to coronary atherosclerosis. Am J Cardiol. 2008;102:1602–7.PubMedCrossRef
14.
Zurück zum Zitat Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108:2460–6.PubMedCrossRef Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003;108:2460–6.PubMedCrossRef
15.
Zurück zum Zitat Kocaman SA, Durakoğlugil ME, Cetin M, et al. The independent relationship of epicardial adipose tissue with carotid intima-media thickness and endothelial functions: the association of pulse wave velocity with the active facilitated arterial conduction concept. Blood Press Monit. 2013;18(2):85–93.PubMedCrossRef Kocaman SA, Durakoğlugil ME, Cetin M, et al. The independent relationship of epicardial adipose tissue with carotid intima-media thickness and endothelial functions: the association of pulse wave velocity with the active facilitated arterial conduction concept. Blood Press Monit. 2013;18(2):85–93.PubMedCrossRef
16.
Zurück zum Zitat Nagasaki T, Inaba M, Henmi Y, et al. Decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function. Clin Endocrinol. 2003;59:607–12.CrossRef Nagasaki T, Inaba M, Henmi Y, et al. Decrease in carotid intima-media thickness in hypothyroid patients after normalization of thyroid function. Clin Endocrinol. 2003;59:607–12.CrossRef
17.
Zurück zum Zitat Yerramasu A, Dey D, Venuraju S, et al. Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis. Atherosclerosis. 2012;220:223–30.PubMedCrossRef Yerramasu A, Dey D, Venuraju S, et al. Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis. Atherosclerosis. 2012;220:223–30.PubMedCrossRef
18.
Zurück zum Zitat Sengul C, Cevik C, Ozveren O, et al. Echocardiographic epicardial fat thickness is associated with carotid intima-media thickness in patients with metabolic syndrome. Echocardiography. 2011;28:853–8.PubMedCrossRef Sengul C, Cevik C, Ozveren O, et al. Echocardiographic epicardial fat thickness is associated with carotid intima-media thickness in patients with metabolic syndrome. Echocardiography. 2011;28:853–8.PubMedCrossRef
19.
Zurück zum Zitat Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001;358(9285):861–5.PubMedCrossRef Parle JV, Maisonneuve P, Sheppard MC, Boyle P, Franklyn JA. Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study. Lancet. 2001;358(9285):861–5.PubMedCrossRef
20.
Zurück zum Zitat Aşık M, Sahin S, Ozkul F, et al. Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis. Clin endocrinol (Oxf). 2013;79(4):571–6. Aşık M, Sahin S, Ozkul F, et al. Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis. Clin endocrinol (Oxf). 2013;79(4):571–6.
21.
Zurück zum Zitat Asik M, Sahin S, Temiz A, et al. Evaluation of epicardial fat tissue thickness in patients with primary hyperparathyroidism. Endocr Pract. 2014;20(1):26–32. doi:10.4158/EP13140.OR. Asik M, Sahin S, Temiz A, et al. Evaluation of epicardial fat tissue thickness in patients with primary hyperparathyroidism. Endocr Pract. 2014;20(1):26–32. doi:10.4158/EP13140.OR.
22.
Zurück zum Zitat Wronska A, Kmiec Z. Structural and biochemical characteristics of various white adipose tissue depots. Acta Physiol (Oxf). 2012;205:194–208.CrossRef Wronska A, Kmiec Z. Structural and biochemical characteristics of various white adipose tissue depots. Acta Physiol (Oxf). 2012;205:194–208.CrossRef
23.
Zurück zum Zitat Sacks HS, Fain JN. Human epicardial fat: what is new and what is missing? Clin Exp Pharmacol Physiol. 2011;38:879–87.PubMedCrossRef Sacks HS, Fain JN. Human epicardial fat: what is new and what is missing? Clin Exp Pharmacol Physiol. 2011;38:879–87.PubMedCrossRef
Metadaten
Titel
Evaluation of epicardial fat tissue thickness in patients with hyperthyroidism
verfasst von
Assist. Prof. Dr. Emine Binnetoğlu, MD
Assist. Prof. Dr. Mehmet Asik
Assist. Prof. Dr. Burak Altun
Assist. Prof. Dr. Hacer Sen
Assist. Prof. Dr. Emine Gazi
Assist. Prof. Dr. Gökhan Erbağ
Assist. Prof. Dr. Fahri Günes
Assist. Dr. Yıldız Garip Bilen
Assist. Prof. Dr. Ahmet Temiz
Assist. Prof. Dr. Ahmet Barutçu
Assist. Prof. Dr. Adem Bekler
Publikationsdatum
01.08.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0570-0

Weitere Artikel der Ausgabe 15-16/2014

Wiener klinische Wochenschrift 15-16/2014 Zur Ausgabe

mitteilungen der gesellschaft der ärzte in wien

BILLROTHHAUS.TV

Editorial

Editorial