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01.05.2014 | original article

Effects of AV-delay optimization on hemodynamic parameters in patients with VDD pacemakers

verfasst von: Konstantin A. Krychtiuk, MD, Michael Nürnberg, MD, Romana Volker, MD, Linda Pachinger, MD, Rudolf Jarai, MD, Matthias K. Freynhofer, MD, Johann Wojta, PhD, Kurt Huber, MD, Thomas W. Weiss, MD, PhD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2014

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Summary

Aim

Atrioventricular (AV) delay optimization improves hemodynamics and clinical parameters in patients treated with cardiac resynchronization therapy and dual-chamber-pacemakers (PM). However, data on optimizing AV delay in patients treated with VDD-PMs are scarce. We, therefore, investigated the acute and chronic effects of AV delay optimization on hemodynamics in patients treated with VDD-PMs due to AV-conduction disturbances.

Methods

In this prospective, single-center interventional trial, we included 64 patients (38 men, 26 women, median age: 77 (70–82) years) with implanted VDD-PM. AV-delay optimization was performed using a formula based on the surface electrocardiogram (ECG). Hemodynamic parameters (stroke volume (SV), cardiac output (CO), heart rate (HR), and blood pressure (BP)) were measured at baseline and follow-up after 3 months using impedance cardiography.

Results

Using an ECG formula for AV-delay optimization, the AV interval was decreased from 180 (180–180) to 75 (75–100) ms. At baseline, AV-delay optimization led to a significant increase of both SV (71.3 ± 15.8 vs. 55.3 ± 12.7 ml, p < 0.001, for optimized AV delay vs. nominal AV interval, respectively) and CO (5.1 ± 1.4 vs. 3.9 ± 1.0 l/min, p < 0.001), while HR and BP remained unchanged. At follow-up, the improvement in CO remained stable (4.9 ± 1.3 l/min, p = 0.09), while SV slightly, but significantly, decreased (to 65.1 ± 17.6, p < 0.01).

Conclusion

AV-delay optimization in patients treated with VDD-PMs exhibits immediate beneficial effects on hemodynamic parameters that are sustained for 3 months.

Vorheriger Artikel Early atherosclerosis in HIV-infected patients below the age of 55 years: Slovenian national study

Nächster Artikel Effects of time of hospital admission on outcomes after severe traumatic brain injury in Austria

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Titel: Effects of AV-delay optimization on hemodynamic parameters in patients with VDD pacemakers
verfasst von: Konstantin A. Krychtiuk, MD
Michael Nürnberg, MD
Romana Volker, MD
Linda Pachinger, MD
Rudolf Jarai, MD
Matthias K. Freynhofer, MD
Johann Wojta, PhD
Kurt Huber, MD
Thomas W. Weiss, MD, PhD
Publikationsdatum: 01.05.2014
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 9-10/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-014-0520-x

Springer Medizin Österreich

Summary

Aim

Methods

Results

Conclusion

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