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Erschienen in: Wiener klinische Wochenschrift 9-10/2014

01.05.2014 | history of medicine

Highlights in thyroidology: a historical vignette

verfasst von: Prof. Michael Weissel

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2014

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Summary

This review gives a historical overview about the development of today’s understanding of benign thyroid diseases and the possibilities of their treatment.
Little was known about the thyroid gland until the nineteenth century: the state of knowledge was (1) that something in food, especially in seaweed, avoided the development of goiters, (2) that goiters seemed to have something to do with cretinism, and (3) that the thyroid gland is an organ consisting of two lobes connected by an isthmus.
Shortly after the detection of iodine in 1811, its impact on its ability to avoid the development and the growing of goiters has been realized.
The existence of iodine within the thyroid and in human plasma was detected approximately a decade later. The clinical picture of hyperthyroidism including endocrine orbitopathy was described in detail in the middle of the nineteenth century, the etiology of the disease remaining, however, unclear until a century later.
In early nineteenth century, surgical goiter exstirpation was the only available form of treatment. Vienna and Berne were the centers leading worldwide in their expertise. Subcutaneous injections of sheep thyroid extracts were developed for treatment of postoperative hypothyroidism as well as congenital myxedema. Another approach suggested by Swiss surgeons was thyroid transplantation. Radioiodine therapy of hyperthyroidism was introduced in the middle of the twentieth century.
Thyrostatic drugs are available since about the same time.
The different forms of thyroiditis were described at the turn of the twentieth century. The etiology of chronic autoimmune thyroiditis was, however, clarified only some 50 years later independently by two groups of scientists, one in London, UK, and the other in Buffalo, USA.
Thyroxine was isolated from bovine thyroid extracts in the beginning of the twentieth century. Its synthesis and correct chemical structure were described some 10 years later. The existence of 3,5,3’-triiodothyronine (T3), the biologically most active thyroid hormone, was detected in the 1950s of the past century by a group in Paris and another in London.
The extrathyroidal conversion of thyroxine to T3, as the main source of circulating T3, was suggested shortly thereafter and substantiated in 1970.
Finally, the development of the radioimmunoassay method for determination of hormone serum concentrations in 1959 enabled today’s exact laboratory diagnosis of thyroid diseases.
Literatur
1.
Zurück zum Zitat Eber O. Zur Entwicklung der Jodsalzprophylaxe in Österreich. (Editorial). Wien. klin. Wochenschr. 1998;110:733–7.PubMed Eber O. Zur Entwicklung der Jodsalzprophylaxe in Österreich. (Editorial). Wien. klin. Wochenschr. 1998;110:733–7.PubMed
3.
Zurück zum Zitat Collins HS. Figure 22 in JH Means: The thyroid and its diseases. 2. Edn. Philadelphia: JB Lippincott Comp; 1948. Collins HS. Figure 22 in JH Means: The thyroid and its diseases. 2. Edn. Philadelphia: JB Lippincott Comp; 1948.
4.
Zurück zum Zitat Janekovic V. Geschichte der medikamentösen Kropfbehandlung. Darstellung des Kropfes in der bildenden Kunst. Edited by E. Merck, Darmstadt ca 1990, p. 27. Janekovic V. Geschichte der medikamentösen Kropfbehandlung. Darstellung des Kropfes in der bildenden Kunst. Edited by E. Merck, Darmstadt ca 1990, p. 27.
5.
Zurück zum Zitat Morgagni adversar I. Seite 35 und ff; V: Seite 66. Epist IX; Nr. 35; quoted after Schmidtmüller JA: Über die Ausführungsgänge der Schilddrüsen. 1803. Landshut J. Attenkoler, (Bookseller). Digitalized by Google. Morgagni adversar I. Seite 35 und ff; V: Seite 66. Epist IX; Nr. 35; quoted after Schmidtmüller JA: Über die Ausführungsgänge der Schilddrüsen. 1803. Landshut J. Attenkoler, (Bookseller). Digitalized by Google.
6.
Zurück zum Zitat Wharton T. Adenographia: sive, glandularum totius corporis descriptio. London 1656 zitiert nach Rolleston HD (1936) The endocrine glands. In: Health and Disease. London: Oxford University Press; 1936. Wharton T. Adenographia: sive, glandularum totius corporis descriptio. London 1656 zitiert nach Rolleston HD (1936) The endocrine glands. In: Health and Disease. London: Oxford University Press; 1936.
7.
Zurück zum Zitat Coindet JF. Découverte d‘un nouveau remède contre le goitre. Annales de Chimie et Physique. 1820:15:49–59. Coindet JF. Découverte d‘un nouveau remède contre le goitre. Annales de Chimie et Physique. 1820:15:49–59.
8.
Zurück zum Zitat Baumann E. Über das normale Vorkommen von Jod im Thierkörper. Hoppe-Seyler‘s Z. Physiol. Chem 1895:21:319. Baumann E. Über das normale Vorkommen von Jod im Thierkörper. Hoppe-Seyler‘s Z. Physiol. Chem 1895:21:319.
9.
Zurück zum Zitat Baumann E. Über das Thyrojodin. Münch Med Wochenschr. 1896:43:309. Baumann E. Über das Thyrojodin. Münch Med Wochenschr. 1896:43:309.
10.
Zurück zum Zitat Baumann E, Goldmann EE. Ist das Jodothyrin (Thyrojodin) der lebenswichtige Bestandtheil der Schilddrüse? Lehmann, Google Book; 1896. Baumann E, Goldmann EE. Ist das Jodothyrin (Thyrojodin) der lebenswichtige Bestandtheil der Schilddrüse? Lehmann, Google Book; 1896.
11.
Zurück zum Zitat Gley E, Bourcet P. Présence de l’iode dans le sang. CR Acad Sci (Paris). 1900:130:1721. Gley E, Bourcet P. Présence de l’iode dans le sang. CR Acad Sci (Paris). 1900:130:1721.
12.
Zurück zum Zitat Wagner-Jauregg J. Über den Kretinismus. Monatsschr Gesundheitspflege. 1898:16/3:57–68. Wagner-Jauregg J. Über den Kretinismus. Monatsschr Gesundheitspflege. 1898:16/3:57–68.
13.
Zurück zum Zitat Zuckerkandl Berta. Österreich intim. Erinnerungen 1892–1942. Frankfurt/M, Berlin: Verlag Ullstein; 1988. pp. 53–54. Zuckerkandl Berta. Österreich intim. Erinnerungen 1892–1942. Frankfurt/M, Berlin: Verlag Ullstein; 1988. pp. 53–54.
14.
Zurück zum Zitat Wagner-Jauregg J. Kropfprophylaxe durch Vollsalz. Wien klin Wochenschr. 1925:38/48:1377–80. Wagner-Jauregg J. Kropfprophylaxe durch Vollsalz. Wien klin Wochenschr. 1925:38/48:1377–80.
15.
Zurück zum Zitat Weissel M. Legal augmentation of iodine content in table salt from 10 to 20 mg KI/kg: documented effects a decade later. Exp Clin Endocrinol Diabetes. 2003;111:187–90. Weissel M. Legal augmentation of iodine content in table salt from 10 to 20 mg KI/kg: documented effects a decade later. Exp Clin Endocrinol Diabetes. 2003;111:187–90.
16.
Zurück zum Zitat Plummer HS, Boothby WM. The value of iodine in exophthalmic goiter; Collected papers of the Mayo Clinic & the Mayo Foundation; 1923. p. XV. Plummer HS, Boothby WM. The value of iodine in exophthalmic goiter; Collected papers of the Mayo Clinic & the Mayo Foundation; 1923. p. XV.
17.
Zurück zum Zitat Parry CH. Collections from the unpublished medical writings. London: Underwood; 1825. p. 111. Parry CH. Collections from the unpublished medical writings. London: Underwood; 1825. p. 111.
18.
Zurück zum Zitat Graves RJ. Clinical lectures: lecture XII. Delivered at the Meath Hospital during the Session of 1834–35. Medical Classics. 1940;5:25. Graves RJ. Clinical lectures: lecture XII. Delivered at the Meath Hospital during the Session of 1834–35. Medical Classics. 1940;5:25.
19.
Zurück zum Zitat Basedow CA. Exophthalmos durch Hypertrophie des Zellgewebes in der Augenhöhle. Wochenschr Ges Heilkunde. 1840;13:197–228. Basedow CA. Exophthalmos durch Hypertrophie des Zellgewebes in der Augenhöhle. Wochenschr Ges Heilkunde. 1840;13:197–228.
20.
Zurück zum Zitat Magnus-Levy A. Über den respiratorischen Gaswechsel unter dem Einfluss der Thyreoidea sowie unter verschiedenen pathologischen Zuständen. Berliner Klin Wochenschr. 1895:32:650. Magnus-Levy A. Über den respiratorischen Gaswechsel unter dem Einfluss der Thyreoidea sowie unter verschiedenen pathologischen Zuständen. Berliner Klin Wochenschr. 1895:32:650.
21.
Zurück zum Zitat Mason RL, Hunt HM, Hurxthal L. Blood cholesterol values in hyperthyroidism and hypothyroidism—their significance. N Engl J Med. 1930; 203: 1273–1278.CrossRef Mason RL, Hunt HM, Hurxthal L. Blood cholesterol values in hyperthyroidism and hypothyroidism—their significance. N Engl J Med. 1930; 203: 1273–1278.CrossRef
22.
Zurück zum Zitat Adams DD, Purves H. Abnormal responses in the assay of thyrotropin. Proceedings of Otago Medical School. 1956:34:11.12. Adams DD, Purves H. Abnormal responses in the assay of thyrotropin. Proceedings of Otago Medical School. 1956:34:11.12.
23.
Zurück zum Zitat Kriss JP, Plashkov V, Chien JR. Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed myxedema. J Clin Endocrinol Metab. 1964 24:1005–28.PubMedCrossRef Kriss JP, Plashkov V, Chien JR. Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed myxedema. J Clin Endocrinol Metab. 1964 24:1005–28.PubMedCrossRef
24.
Zurück zum Zitat Mc Kenzie JM, Williamson A. Experience with the bio-assay of the long-acting thyroid stimulator. J Clin Endocrinol Metab. 1966:26:518–26.CrossRef Mc Kenzie JM, Williamson A. Experience with the bio-assay of the long-acting thyroid stimulator. J Clin Endocrinol Metab. 1966:26:518–26.CrossRef
25.
Zurück zum Zitat Mc Kenzie JM. Humoral factors in the pathogenesis of Graves’disease. Physiol Rev. 1968:48:1005–28. Mc Kenzie JM. Humoral factors in the pathogenesis of Graves’disease. Physiol Rev. 1968:48:1005–28.
26.
Zurück zum Zitat Smith BR, Hall R. Thyroid-stimulating immunoglobulins in Graves’ disease. Lancet. 1974;2:427–31.PubMedCrossRef Smith BR, Hall R. Thyroid-stimulating immunoglobulins in Graves’ disease. Lancet. 1974;2:427–31.PubMedCrossRef
27.
Zurück zum Zitat Smith BR. Hall R Binding of thyroid stimulators to thyroid membranes. FEBS Letter. 1974;42(3):301–4.CrossRef Smith BR. Hall R Binding of thyroid stimulators to thyroid membranes. FEBS Letter. 1974;42(3):301–4.CrossRef
28.
Zurück zum Zitat Mehdi SQ, Nussey SS. A radio-ligand receptor assay for the long-acting thyroid stimulator. Inhibition by the long-acting thyroid stimulator of the binding of radioiodinated thyroid-stimulating hormone to human thyroid membranes. Biochem J. 1975:145:105–11.PubMedCentralPubMed Mehdi SQ, Nussey SS. A radio-ligand receptor assay for the long-acting thyroid stimulator. Inhibition by the long-acting thyroid stimulator of the binding of radioiodinated thyroid-stimulating hormone to human thyroid membranes. Biochem J. 1975:145:105–11.PubMedCentralPubMed
29.
Zurück zum Zitat Schleusener H, Kotulla P, Adlkofer F, Nussey SS, Mehdi SQ. Clinical application of a radioreceptor assay for thyroid stimulators. Horm Metab Res. 1975 Jul;7(4):360–1.PubMedCrossRef Schleusener H, Kotulla P, Adlkofer F, Nussey SS, Mehdi SQ. Clinical application of a radioreceptor assay for thyroid stimulators. Horm Metab Res. 1975 Jul;7(4):360–1.PubMedCrossRef
30.
Zurück zum Zitat Southgate K, Creagh F, Teece M, Kingswood C, Rees Smith B. A receptor assay for the measurement of TSH receptor antibodies in unextracted serum. Clin Endocrinol (Oxf). 1984:20(5):539–48. Southgate K, Creagh F, Teece M, Kingswood C, Rees Smith B. A receptor assay for the measurement of TSH receptor antibodies in unextracted serum. Clin Endocrinol (Oxf). 1984:20(5):539–48.
31.
Zurück zum Zitat Parmentier M, Libert F, Maenhaut C, Lefort A, Gérard C, Perret J, van Sande J, Dumont JE, Vassart G. Molecular cloning of the thyrotropin receptor. Science. 1989:246:1620–5.PubMedCrossRef Parmentier M, Libert F, Maenhaut C, Lefort A, Gérard C, Perret J, van Sande J, Dumont JE, Vassart G. Molecular cloning of the thyrotropin receptor. Science. 1989:246:1620–5.PubMedCrossRef
32.
Zurück zum Zitat Richter CR, Clisby KH. Toxic effect of the bitter tasting phenylthiocarbamide. Arch Pathol. 1942:33:46. Richter CR, Clisby KH. Toxic effect of the bitter tasting phenylthiocarbamide. Arch Pathol. 1942:33:46.
33.
Zurück zum Zitat MacKenzie JB, MacKenzie CG, Mc Collum EV. Effect of sulfanilylguanine on the thyroid of the rat. Science. 1941:94:518–9.PubMedCrossRef MacKenzie JB, MacKenzie CG, Mc Collum EV. Effect of sulfanilylguanine on the thyroid of the rat. Science. 1941:94:518–9.PubMedCrossRef
34.
Zurück zum Zitat Astwood EB. The chemical nature of compounds which inhibit the function of the thyroid gland. J Pharmacol Exp Ther. 1943:78:79. Astwood EB. The chemical nature of compounds which inhibit the function of the thyroid gland. J Pharmacol Exp Ther. 1943:78:79.
35.
Zurück zum Zitat Astwood EB. Treatment of hyperthyroidism with thiourea and thiouracil. JAMA. 1943:122:78–81.CrossRef Astwood EB. Treatment of hyperthyroidism with thiourea and thiouracil. JAMA. 1943:122:78–81.CrossRef
36.
Zurück zum Zitat Rivkees SA, Mattison DR. Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use. Int J Pediatr Endocrinol. 2009: 2009:Article ID:132041. Rivkees SA, Mattison DR. Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use. Int J Pediatr Endocrinol. 2009: 2009:Article ID:132041.
37.
Zurück zum Zitat Sawin CT, Becker DV. Radioiodine and the treatment of hyperthyroidism: the early history. Thyroid. 1997:7:163–76.PubMedCrossRef Sawin CT, Becker DV. Radioiodine and the treatment of hyperthyroidism: the early history. Thyroid. 1997:7:163–76.PubMedCrossRef
38.
Zurück zum Zitat Hevesy G. The absorption and translocation of lead by plants. A contribution to the application of the method of radioactive indicators in the investigation of the change of substance in plants. Biochem J. 1923;17:439.PubMedCentralPubMed Hevesy G. The absorption and translocation of lead by plants. A contribution to the application of the method of radioactive indicators in the investigation of the change of substance in plants. Biochem J. 1923;17:439.PubMedCentralPubMed
39.
Zurück zum Zitat Hertz S, Roberts A, Evans RD. Radioactive iodine as an indicator in the study of thyroid physiology. Proc Soc Exper Biol Med. 1938;38:510. Hertz S, Roberts A, Evans RD. Radioactive iodine as an indicator in the study of thyroid physiology. Proc Soc Exper Biol Med. 1938;38:510.
40.
Zurück zum Zitat Hamilton JG, Soley MH. Studies in iodine metabolism of the thyroid gland by the use of radio-iodine in normal subjects and in patients with various types of goiter Am J Physiol. 1940;131:135. Hamilton JG, Soley MH. Studies in iodine metabolism of the thyroid gland by the use of radio-iodine in normal subjects and in patients with various types of goiter Am J Physiol. 1940;131:135.
41.
Zurück zum Zitat Hertz S, Roberts A. Radioactive iodine in the study of thyroid physiology VII. The use of radioactive iodine therapy in hyperthyroidism. JAMA. 1946;131:81–5.CrossRef Hertz S, Roberts A. Radioactive iodine in the study of thyroid physiology VII. The use of radioactive iodine therapy in hyperthyroidism. JAMA. 1946;131:81–5.CrossRef
43.
Zurück zum Zitat Seidlin SM, Marinelli LD, Oshry E. Radioactive iodine therapy; effect on functioning metastases of adenocarcinoma of the thyroid. J Am Med Assoc. 1946 Dec 7;132(14):838–4.PubMedCrossRef Seidlin SM, Marinelli LD, Oshry E. Radioactive iodine therapy; effect on functioning metastases of adenocarcinoma of the thyroid. J Am Med Assoc. 1946 Dec 7;132(14):838–4.PubMedCrossRef
44.
Zurück zum Zitat Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996 Feb 1;379(6564):458–60.PubMedCrossRef Dai G, Levy O, Carrasco N. Cloning and characterization of the thyroid iodide transporter. Nature. 1996 Feb 1;379(6564):458–60.PubMedCrossRef
45.
Zurück zum Zitat Diamantis A, Magiorkis E, Koutselini H. Fine-needle aspiration (FNA) biopsy: historical aspects. Folia Histochem Cytobiol. 2009:191–7. Diamantis A, Magiorkis E, Koutselini H. Fine-needle aspiration (FNA) biopsy: historical aspects. Folia Histochem Cytobiol. 2009:191–7.
46.
Zurück zum Zitat Kocher T. Über Kropfexstirpation und ihre Folgen. Archiv für klinische Chirurgie. 1883:39:254–335. Kocher T. Über Kropfexstirpation und ihre Folgen. Archiv für klinische Chirurgie. 1883:39:254–335.
47.
Zurück zum Zitat Wolfer (Wölfler?) A. Die Kropfexstirpation an Hofrat Billroth‘s Klinik von 1877–1881. Wiener med Wochenschr. 1882;XXXII:5. Wolfer (Wölfler?) A. Die Kropfexstirpation an Hofrat Billroth‘s Klinik von 1877–1881. Wiener med Wochenschr. 1882;XXXII:5.
48.
Zurück zum Zitat Gull WW. On a cretinoid state supervening in adult life in women. Trans Clin Soc Lond. 1873–1874:7180. Gull WW. On a cretinoid state supervening in adult life in women. Trans Clin Soc Lond. 1873–1874:7180.
49.
Zurück zum Zitat Horsley V. On the function of the thyroid gland: proceedings of the Royal Soc. of London (1854–1905): 11.12. 1884:38:5–7. Horsley V. On the function of the thyroid gland: proceedings of the Royal Soc. of London (1854–1905): 11.12. 1884:38:5–7.
51.
Zurück zum Zitat Bettencourt R. Serrano J-A Un cas de myxœdème (cachexie pachydermique) traité par la greffe hypodermique du corps thyroïde d’un mouton. Compte rendu de la 19eme session de l‘Association française pour l’avancement des sciences, Limoges; 1890. pp 683–90. Bettencourt R. Serrano J-A Un cas de myxœdème (cachexie pachydermique) traité par la greffe hypodermique du corps thyroïde d’un mouton. Compte rendu de la 19eme session de l‘Association française pour l’avancement des sciences, Limoges; 1890. pp 683–90.
52.
Zurück zum Zitat Murray GR. Note on the treatment of myxedema by hypodermic injections of an extract of the thyroid gland of a sheep. Brit med J. 1891:796–7. Murray GR. Note on the treatment of myxedema by hypodermic injections of an extract of the thyroid gland of a sheep. Brit med J. 1891:796–7.
53.
Zurück zum Zitat Murray GR. The life history of the first case of myxoedema treated by thyroid extract. Brit med J. 1920;i:359–60. Murray GR. The life history of the first case of myxoedema treated by thyroid extract. Brit med J. 1920;i:359–60.
54.
Zurück zum Zitat Kocher A. The treatment of hypothyroidism by thyroid transplantation. Br med J. 1923:560–1. Kocher A. The treatment of hypothyroidism by thyroid transplantation. Br med J. 1923:560–1.
55.
Zurück zum Zitat Mygind H. Thyroiditis acuta simplex. J Laryngol. 1895:91:181–93. Mygind H. Thyroiditis acuta simplex. J Laryngol. 1895:91:181–93.
56.
Zurück zum Zitat De Quervain F. Die akute nicht eitrige Thyreoiditis. Mitteilungen aus den Grenzge-bieten der Medizin und Chirurgie: 1904: 2. Supplement Band 1: 165, 6pt. De Quervain F. Die akute nicht eitrige Thyreoiditis. Mitteilungen aus den Grenzge-bieten der Medizin und Chirurgie: 1904: 2. Supplement Band 1: 165, 6pt.
57.
Zurück zum Zitat Riedel B. Zu Tumoren führende Entzündung der Schilddrüse. Verh Dtsch Ges Chir. 1896;25:101–5. Riedel B. Zu Tumoren führende Entzündung der Schilddrüse. Verh Dtsch Ges Chir. 1896;25:101–5.
58.
Zurück zum Zitat Hashimoto H. Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa) Archiv für Klinische Chirurgie. 1912:97:219–48. Hashimoto H. Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa) Archiv für Klinische Chirurgie. 1912:97:219–48.
60.
Zurück zum Zitat Rose NR, Witebsky E. Studies in organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J Immunol. 1956:76:417–27.PubMed Rose NR, Witebsky E. Studies in organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J Immunol. 1956:76:417–27.PubMed
61.
Zurück zum Zitat Campbell PN, Doniach D, Hudson RV, Roitt M. Autoantibodies in Hashimoto’s disease (lymphadeonoid goitre). Lancet. 1956:271:820–1.PubMed Campbell PN, Doniach D, Hudson RV, Roitt M. Autoantibodies in Hashimoto’s disease (lymphadeonoid goitre). Lancet. 1956:271:820–1.PubMed
62.
63.
64.
Zurück zum Zitat Duntas LH, Hiromatsu Y, Amino N. Centennial of the description of Hashimoto’s thyroiditis: two thought-provoking events. Thyroid. 2013:23:643–5.PubMedCrossRef Duntas LH, Hiromatsu Y, Amino N. Centennial of the description of Hashimoto’s thyroiditis: two thought-provoking events. Thyroid. 2013:23:643–5.PubMedCrossRef
65.
Zurück zum Zitat Kendall EC. The isolation in crystalline form of the compound containing iodin which occurs in the thyroid. Its chemical nature and physiologic activity. JAMA. 1915;64:2042.CrossRef Kendall EC. The isolation in crystalline form of the compound containing iodin which occurs in the thyroid. Its chemical nature and physiologic activity. JAMA. 1915;64:2042.CrossRef
66.
Zurück zum Zitat Harington CR. Chemistry of Thyroxine. II. Constitution and synthesis of desiodo-thyroxine. Biochem J. 1926;20:300.PubMedCentralPubMed Harington CR. Chemistry of Thyroxine. II. Constitution and synthesis of desiodo-thyroxine. Biochem J. 1926;20:300.PubMedCentralPubMed
68.
Zurück zum Zitat Lyon DM. Note on the physiological test of synthetic thyroxine. Biochem J. 1927;21:181–3. Lyon DM. Note on the physiological test of synthetic thyroxine. Biochem J. 1927;21:181–3.
69.
Zurück zum Zitat Gross J, Pitt-Rivers R. The identification of 3,5,3’-L-triiodothyronine in human plasma. The Lancet. 1952 (March 1);i:439–41. Gross J, Pitt-Rivers R. The identification of 3,5,3’-L-triiodothyronine in human plasma. The Lancet. 1952 (March 1);i:439–41.
70.
Zurück zum Zitat Roche J, Lissitzky S, Michel R. Sur la triiothyronine, produit intermédiaire de la transformation de la diiodothyronine en thyroxine. Paris: C. R. Acad. Sci. 1952 (25 Fév.);234:997–8. Roche J, Lissitzky S, Michel R. Sur la triiothyronine, produit intermédiaire de la transformation de la diiodothyronine en thyroxine. Paris: C. R. Acad. Sci. 1952 (25 Fév.);234:997–8.
71.
Zurück zum Zitat Pitt-Rivers R, Stanbury JB, Rapp B. Conversion of thyroxin to 3,5,3’triiodothyro-nine in vivo. J Clin Endocrinol. 1955;15:616–20. Pitt-Rivers R, Stanbury JB, Rapp B. Conversion of thyroxin to 3,5,3’triiodothyro-nine in vivo. J Clin Endocrinol. 1955;15:616–20.
72.
73.
Zurück zum Zitat Schadlow AR, Surks MI, Schwartz HL, Oppenheimer JH. Specific triiodothyronine binding sites in the anterior pituitary of the rat. Science. 1972;176:1252–4.PubMedCrossRef Schadlow AR, Surks MI, Schwartz HL, Oppenheimer JH. Specific triiodothyronine binding sites in the anterior pituitary of the rat. Science. 1972;176:1252–4.PubMedCrossRef
74.
Zurück zum Zitat Oppenheimer JH, Schwartz HL, Surks MI, Koerner D, Dillmann W: Nuclear receptors and the initiation of thyroid hormone action. Recent Progr Horm Res 1976: 32: 529. Oppenheimer JH, Schwartz HL, Surks MI, Koerner D, Dillmann W: Nuclear receptors and the initiation of thyroid hormone action. Recent Progr Horm Res 1976: 32: 529.
75.
Zurück zum Zitat Yalow RS, Berson SA. Assay of plasma insulin in human subjects by immunological methods. Nature. 1959;184 (Suppl 21):1648–9. Yalow RS, Berson SA. Assay of plasma insulin in human subjects by immunological methods. Nature. 1959;184 (Suppl 21):1648–9.
76.
Zurück zum Zitat Utiger RD. Radioimmunoassay of human plasma thyrotropin. J Clin Invest. 1965;44:1277–86. Utiger RD. Radioimmunoassay of human plasma thyrotropin. J Clin Invest. 1965;44:1277–86.
77.
Zurück zum Zitat Ingbar SH, Braverman LE, Dawber NA, Lee GY. A new method for measuring the free thyroid hormone in human serum and an analysis of the factors that influence its concentration. J Clin Invest. 1965;44:1679–89.PubMedCentralPubMedCrossRef Ingbar SH, Braverman LE, Dawber NA, Lee GY. A new method for measuring the free thyroid hormone in human serum and an analysis of the factors that influence its concentration. J Clin Invest. 1965;44:1679–89.PubMedCentralPubMedCrossRef
79.
80.
Zurück zum Zitat Van Herle AJ, Uller RP, Matthews NL, Brown J. Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest. 1973;52:1320–7. Van Herle AJ, Uller RP, Matthews NL, Brown J. Radioimmunoassay for measurement of thyroglobulin in human serum. J Clin Invest. 1973;52:1320–7.
Metadaten
Titel
Highlights in thyroidology: a historical vignette
verfasst von
Prof. Michael Weissel
Publikationsdatum
01.05.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0515-7

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