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Wiener klinische Wochenschrift

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01.06.2013 | original article

Nutritional supplements and plasma antioxidants in childhood asthma

verfasst von: Elisabeth Fabian, PhD, Peter Pölöskey, MD, Lajos Kósa, MD, Ibrahim Elmadfa, Lajos Attila Réthy

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2013

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Abstract

Objective

This study investigated the relationship of plasma antioxidants to airway inflammation and systemic oxidative stress in children suffering from atopic asthma with consideration of the intake of nutritional supplements.

Subjects and research methods

A total of 35 asthmatic children (AG) and 21 healthy controls (CG) participated in this study. Plasma levels of vitamins A and E, β-carotene, coenzyme Q10 and malondialdehyde (MDA) were analyzed with high-performance liquid chromatography (HPLC); the total antioxidant capacity (TAC) was measured photometrically, and selenium was determined by atomic absorption spectroscopy (AAS). The volume of fractionated exhaled nitric oxide (FeNO) was measured with the NIOX nitric oxide monitoring system.

Results

The plasma antioxidants vitamins A and E, selenium, and coenzyme Q10 but not β-carotene were significantly (p < 0.05) lower in asthmatics than in controls. Further, asthmatic children had significantly reduced plasma concentrations of TAC (p < 0.01), significantly enhanced levels of MDA (p < 0.001), and exhaled a significantly (p < 0.001) higher mean volume of FeNO than healthy children. Regular intake of supplements had a significant positive influence on plasma vitamin E (p < 0.01), selenium (p < 0.01), TAC (p < 0.05), MDA (p < 0.01), and FeNO (p < 0.01) in asthmatics but not in controls. Additionally, significant negative associations of vitamin E and MDA (AG: p < 0.01; CG: p < 0.05), and vitamin E and FeNO (AG: p < 0.05; CG: p > 0.05) were identified.

Conclusion

These results indicate that nutritional supplements beneficially modulate plasma antioxidants and thus might have a positive influence on systemic redox balance and subsequently, pulmonary inflammation in asthmatic children.

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Titel: Nutritional supplements and plasma antioxidants in childhood asthma
verfasst von: Elisabeth Fabian, PhD
Peter Pölöskey, MD
Lajos Kósa, MD
Ibrahim Elmadfa
Lajos Attila Réthy
Publikationsdatum: 01.06.2013
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 11-12/2013
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-013-0359-6

Springer Medizin Österreich

Abstract

Objective

Subjects and research methods

Results

Conclusion

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