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Erschienen in: Wiener Medizinische Wochenschrift 21-22/2012

01.11.2012 | main topic

Biomarkers of bone turnover in diagnosis and therapy of osteoporosis

A consensus advice from an Austrian working group

verfasst von: Univ.-Prof. Christian Bieglmayer, Ph.D., Univ.-Prof. Hans Peter Dimai, M.D., Univ.-Prof. Rudolf Wolfgang Gasser, M.D., Univ.-Doz. Stefan Kudlacek, M.D., Univ.-Prof. Barbara Obermayer-Pietsch, M.D., Univ.-Prof. Wolfgang Woloszczuk, Ph.D., Elisabeth Zwettler, M.D., Univ.-Prof. Andrea Griesmacher, M.D.

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 21-22/2012

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Summary

Aim

Reasonable application of laboratory parameters in prevention, diagnosis, treatment and therapy monitoring of osteoporosis.

Target groups

Physicians from different specialist disciplines (general medicine, geriatrics, gynaecology, urology, internal medicine—especially endocrinology and metabolism, nephrology, laboratory medicine, rheumatology, nuclear medicine, orthopaedics, paediatrics, rehabilitation and physical medicine, radiology, social medicine, transplantation medicine, accident surgery), moreover social insurances, hospitals and self-help groups.

Background

Evaluation of aetiology of bone disorders, widening of the therapeutic spectrum for diseases of bone and knowledge on biochemical markers of bone turnover. Improvements in judging the success of therapy and in monitoring the compliance of patients. Research perspectives.

Bases

Scientific literature and guidelines, consensus meetings.

Résumé

Basic and specialized laboratory investigations are important in differentiation between primary and secondary osteoporosis for an adequate therapy. Biochemical markers of bone turnover are an additional aid in evaluation of individual fracture risk. These markers identify responders to bone therapy faster than surveillance of bone mineral density, which helps to improve patient’s compliance too. Characteristics, preanalytic precautions and applications are presented for selected markers of bone resorption and formation and for parameters regulating bone metabolism.
Literatur
1.
Zurück zum Zitat Seibel MJ. Biochemical markers of bone remodelling. Endocrinol Metab Clin North Am. 2003;32:83–113.PubMedCrossRef Seibel MJ. Biochemical markers of bone remodelling. Endocrinol Metab Clin North Am. 2003;32:83–113.PubMedCrossRef
2.
Zurück zum Zitat Delmas PD, Eastell R, Garnero P, et al. The use of biochemical markers of bone turnover in osteoporosis. Osteoporos Int. 2000;11(Suppl 6):S2–17.PubMedCrossRef Delmas PD, Eastell R, Garnero P, et al. The use of biochemical markers of bone turnover in osteoporosis. Osteoporos Int. 2000;11(Suppl 6):S2–17.PubMedCrossRef
3.
Zurück zum Zitat WHO Technical report series—assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva: WHO; 1994. WHO Technical report series—assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Geneva: WHO; 1994.
4.
Zurück zum Zitat Kanis J, Melton L, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137–41.PubMedCrossRef Kanis J, Melton L, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1137–41.PubMedCrossRef
5.
Zurück zum Zitat Johnell O, Kanis J. Epidemiology of osteoporotic fractures. Osteoporos Int. 2005;16(Suppl 2):S3–7.PubMedCrossRef Johnell O, Kanis J. Epidemiology of osteoporotic fractures. Osteoporos Int. 2005;16(Suppl 2):S3–7.PubMedCrossRef
6.
Zurück zum Zitat Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2:285–9.PubMedCrossRef Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2:285–9.PubMedCrossRef
7.
Zurück zum Zitat Cooper C, Cole ZA, Holroyd CR, et al. and IOF CSA Working Group on Fracture Epidemiology. Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int. 2011;22:1277–88.PubMedCrossRef Cooper C, Cole ZA, Holroyd CR, et al. and IOF CSA Working Group on Fracture Epidemiology. Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int. 2011;22:1277–88.PubMedCrossRef
8.
Zurück zum Zitat Dimai HP, Svedbom A, Fahrleitner-Pammer A, et al. Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int. 2011;22:685–92.PubMedCrossRef Dimai HP, Svedbom A, Fahrleitner-Pammer A, et al. Epidemiology of hip fractures in Austria: evidence for a change in the secular trend. Osteoporos Int. 2011;22:685–92.PubMedCrossRef
9.
Zurück zum Zitat Cauley JA, Thompson DE, Ensrud KC, et al. Risk of mortality following clinical fractures. Osteoporos Int. 2000;11:556–61.PubMedCrossRef Cauley JA, Thompson DE, Ensrud KC, et al. Risk of mortality following clinical fractures. Osteoporos Int. 2000;11:556–61.PubMedCrossRef
10.
Zurück zum Zitat Kanis JA, Borgstrom F, De Laet C, Johansson H, et al. Assessment of fracture risk. Osteoporos Int. 2005;16:581–9.PubMedCrossRef Kanis JA, Borgstrom F, De Laet C, Johansson H, et al. Assessment of fracture risk. Osteoporos Int. 2005;16:581–9.PubMedCrossRef
11.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, et al. FRAX™ and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19:385–97.PubMedCrossRef Kanis JA, Johnell O, Oden A, et al. FRAX™ and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19:385–97.PubMedCrossRef
12.
Zurück zum Zitat Anderson F, Francis R, Selby P, et al. Sex hormones and osteoporosis in men. Calcif Tissue Int. 1998;68:185–8.CrossRef Anderson F, Francis R, Selby P, et al. Sex hormones and osteoporosis in men. Calcif Tissue Int. 1998;68:185–8.CrossRef
13.
Zurück zum Zitat Ludwig H, Fritz E, Friedl H. Epidemiologic and age dependent data on multiple myeloma in Austria. J Nat Cancer Inst. 1982;68:729–33.PubMed Ludwig H, Fritz E, Friedl H. Epidemiologic and age dependent data on multiple myeloma in Austria. J Nat Cancer Inst. 1982;68:729–33.PubMed
14.
Zurück zum Zitat McFarlane X, Bhalla A, Reeves D, et al. Osteoporosis in treated adult coeliac disease. Gut. 1995;36:710–4.PubMedCrossRef McFarlane X, Bhalla A, Reeves D, et al. Osteoporosis in treated adult coeliac disease. Gut. 1995;36:710–4.PubMedCrossRef
15.
Zurück zum Zitat Szulc P, Delmas PD. Biochemical markers of bone turnover: potential use in the investigation and management of postmenopausal osteoporosis. Osteoporos Int. 2008;19:1683–704.PubMedCrossRef Szulc P, Delmas PD. Biochemical markers of bone turnover: potential use in the investigation and management of postmenopausal osteoporosis. Osteoporos Int. 2008;19:1683–704.PubMedCrossRef
16.
Zurück zum Zitat Kanis JA, Stevenson M, McCloskey EV, Davis S, Lloyd-Jones M. Glucocorticoid-induced osteoporosis: a systematic review and cost-utility analysis. Health Technol Assess. 2007;11:1–231. Kanis JA, Stevenson M, McCloskey EV, Davis S, Lloyd-Jones M. Glucocorticoid-induced osteoporosis: a systematic review and cost-utility analysis. Health Technol Assess. 2007;11:1–231.
17.
Zurück zum Zitat Takkouche B, Montes-Martinez A, Gill SS, et al. Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf. 2007;30:171–84.PubMedCrossRef Takkouche B, Montes-Martinez A, Gill SS, et al. Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf. 2007;30:171–84.PubMedCrossRef
18.
Zurück zum Zitat Christiansen C, Baastrup PC, Transbol I. Osteopenia and dysregulation of divalent cations in lithium-treated patients. Neuropsychobiology. 1975;1:344–54.PubMedCrossRef Christiansen C, Baastrup PC, Transbol I. Osteopenia and dysregulation of divalent cations in lithium-treated patients. Neuropsychobiology. 1975;1:344–54.PubMedCrossRef
19.
Zurück zum Zitat Zamani A, Omrani GR, Nasab MM. Lithium’s effect on bone mineral density. Bone. 2009;44:331–4.PubMedCrossRef Zamani A, Omrani GR, Nasab MM. Lithium’s effect on bone mineral density. Bone. 2009;44:331–4.PubMedCrossRef
20.
Zurück zum Zitat Targownik LE, Lix LM, Metge CJ, et al. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ. 2008;179:319–26.PubMedCrossRef Targownik LE, Lix LM, Metge CJ, et al. Use of proton pump inhibitors and risk of osteoporosis-related fractures. CMAJ. 2008;179:319–26.PubMedCrossRef
21.
Zurück zum Zitat Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180:32–9.PubMedCrossRef Loke YK, Singh S, Furberg CD. Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis. CMAJ. 2009;180:32–9.PubMedCrossRef
22.
Zurück zum Zitat Jamal SA, Browner WS, Bauer DC, et al. Warfarin use and risk for osteoporosis in elderly women. Study of osteoporotic fractures research group. Ann Intern Med. 1998;128:829–832.PubMed Jamal SA, Browner WS, Bauer DC, et al. Warfarin use and risk for osteoporosis in elderly women. Study of osteoporotic fractures research group. Ann Intern Med. 1998;128:829–832.PubMed
23.
Zurück zum Zitat Rezaieyazdi Z, Falsoleiman H, Khajehdaluee M, et al. Reduced bone density in patients on long term warfarin. Int J Rheum Dis. 2009;12:130–5PubMedCrossRef Rezaieyazdi Z, Falsoleiman H, Khajehdaluee M, et al. Reduced bone density in patients on long term warfarin. Int J Rheum Dis. 2009;12:130–5PubMedCrossRef
24.
Zurück zum Zitat Kanis JA, Melton LJ, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1117–41. Kanis JA, Melton LJ, Christiansen C, et al. The diagnosis of osteoporosis. J Bone Miner Res. 1994;9:1117–41.
25.
Zurück zum Zitat Kanis JA, Johnell O, Oden A, et al. Risk of hip fracture according to the World Health Organization criteria for osteoporosis and osteopenia. Bone. 2000;27:585–90.PubMedCrossRef Kanis JA, Johnell O, Oden A, et al. Risk of hip fracture according to the World Health Organization criteria for osteoporosis and osteopenia. Bone. 2000;27:585–90.PubMedCrossRef
26.
Zurück zum Zitat Cummings S, Black D, Nevitt M. for the study of osteoporotic fractures research group. Bone density at various sites for prediction of hip fractures. Lancet. 1993;341,72–5.PubMedCrossRef Cummings S, Black D, Nevitt M. for the study of osteoporotic fractures research group. Bone density at various sites for prediction of hip fractures. Lancet. 1993;341,72–5.PubMedCrossRef
27.
Zurück zum Zitat Cooper C, Atkinson E, Jacobsen S, et al. Population based study of survival following osteoporotic fractures. Am J Epidemiol. 1993;137:1001–5.PubMed Cooper C, Atkinson E, Jacobsen S, et al. Population based study of survival following osteoporotic fractures. Am J Epidemiol. 1993;137:1001–5.PubMed
28.
Zurück zum Zitat Kudlacek S, Schneider B, Resch H, et al. Die lumbale BMD – Risikofaktor für Wirbelkörperfrakturen bei der Frau. Dtsch Med Wschr. 1998;123:651–7.PubMedCrossRef Kudlacek S, Schneider B, Resch H, et al. Die lumbale BMD – Risikofaktor für Wirbelkörperfrakturen bei der Frau. Dtsch Med Wschr. 1998;123:651–7.PubMedCrossRef
29.
Zurück zum Zitat Dobnig H. A review of the health consequences of the vitamin D deficiency pandemic. J Neurol Sci. 2011 Sept 21. Epub ahead of print. Dobnig H. A review of the health consequences of the vitamin D deficiency pandemic. J Neurol Sci. 2011 Sept 21. Epub ahead of print.
30.
Zurück zum Zitat Sahota O, Mundey MK, San P, et al. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone. 2004;35:312–9.PubMedCrossRef Sahota O, Mundey MK, San P, et al. The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone. 2004;35:312–9.PubMedCrossRef
31.
Zurück zum Zitat Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006 Jul;84:18–28.PubMed Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006 Jul;84:18–28.PubMed
32.
Zurück zum Zitat Kudlacek S, Schneider B, Peterlik M, et al. And Austrian study group on normative values of bone metabolism. Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest. 2003;33:323–31.PubMedCrossRef Kudlacek S, Schneider B, Peterlik M, et al. And Austrian study group on normative values of bone metabolism. Assessment of vitamin D and calcium status in healthy adult Austrians. Eur J Clin Invest. 2003;33:323–31.PubMedCrossRef
33.
Zurück zum Zitat Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004;116:634–9.PubMedCrossRef Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004;116:634–9.PubMedCrossRef
34.
Zurück zum Zitat Garnero P, Munoz F, Sornay-Rendu E, et al. Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study. Bone. 2007;40:716–22.PubMedCrossRef Garnero P, Munoz F, Sornay-Rendu E, et al. Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study. Bone. 2007;40:716–22.PubMedCrossRef
35.
Zurück zum Zitat Meier C, Woitge HW, Witte K, et al. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. J Bone Miner Res. 2004;19:1221–30.PubMedCrossRef Meier C, Woitge HW, Witte K, et al. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. J Bone Miner Res. 2004;19:1221–30.PubMedCrossRef
36.
Zurück zum Zitat Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293:2257–64.PubMedCrossRef Bischoff-Ferrari HA, Willett WC, Wong JB, et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293:2257–64.PubMedCrossRef
37.
Zurück zum Zitat Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. and Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.PubMedCrossRef Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. and Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30.PubMedCrossRef
38.
Zurück zum Zitat Garnero P, Hausherr E, Chapuy MC, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res. 1996;11:1531–8.PubMedCrossRef Garnero P, Hausherr E, Chapuy MC, et al. Markers of bone resorption predict hip fracture in elderly women: the EPIDOS prospective study. J Bone Miner Res. 1996;11:1531–8.PubMedCrossRef
39.
Zurück zum Zitat Garnero P, Sornay-Rendu E, Duboeuf F, et al. Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: the OFELY study. J Bone Miner Res. 1999;14:1614–21.PubMedCrossRef Garnero P, Sornay-Rendu E, Duboeuf F, et al. Markers of bone turnover predict postmenopausal forearm bone loss over 4 years: the OFELY study. J Bone Miner Res. 1999;14:1614–21.PubMedCrossRef
40.
Zurück zum Zitat Garnero P, Sornay-Rendu E, Claustrat B et al. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women. The OFELY study. J Bone Min Res. 2000;15:1526–36.CrossRef Garnero P, Sornay-Rendu E, Claustrat B et al. Biochemical markers of bone turnover, endogenous hormones and the risk of fractures in postmenopausal women. The OFELY study. J Bone Min Res. 2000;15:1526–36.CrossRef
41.
Zurück zum Zitat Garnero P, Delmas PD. Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women. J Musculoskelet Neuronal Interact. 2004;4:50–63.PubMed Garnero P, Delmas PD. Contribution of bone mineral density and bone turnover markers to the estimation of risk of osteoporotic fracture in postmenopausal women. J Musculoskelet Neuronal Interact. 2004;4:50–63.PubMed
42.
Zurück zum Zitat Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature. 1994;367:284–7.PubMedCrossRef Morrison NA, Qi JC, Tokita A, et al. Prediction of bone density from vitamin D receptor alleles. Nature. 1994;367:284–7.PubMedCrossRef
43.
Zurück zum Zitat Obermayer-Pietsch BM, Bonelli CM, Walter DE, et al. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res. 2004;19:42–7.PubMedCrossRef Obermayer-Pietsch BM, Bonelli CM, Walter DE, et al. Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. J Bone Miner Res. 2004;19:42–7.PubMedCrossRef
44.
Zurück zum Zitat Gugatschka M, Dobnig H, Fahrleitner-Pammer A, et al. Molecularly defined lactose malabsorption, milk consumption and anthropometric differences in adult males. Quart J Med. 2005;12:857–63.CrossRef Gugatschka M, Dobnig H, Fahrleitner-Pammer A, et al. Molecularly defined lactose malabsorption, milk consumption and anthropometric differences in adult males. Quart J Med. 2005;12:857–63.CrossRef
45.
Zurück zum Zitat Ji GR, Yao M, Sun CY, et al. Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis. J Int Med Res. 2009;37:1725–32.PubMed Ji GR, Yao M, Sun CY, et al. Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis. J Int Med Res. 2009;37:1725–32.PubMed
46.
Zurück zum Zitat Garnero P, Sornay-Rendu E, Chapuy MC, et al. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res. 1996;11:337–49.PubMedCrossRef Garnero P, Sornay-Rendu E, Chapuy MC, et al. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res. 1996;11:337–49.PubMedCrossRef
47.
Zurück zum Zitat Srivastava AK Vilet EL, Lewiecki EM, et al. Clinical use of serum and urine bone markers in the management of osteoporosis. Curr Med Res Opin. 2005;21:1015–26.PubMedCrossRef Srivastava AK Vilet EL, Lewiecki EM, et al. Clinical use of serum and urine bone markers in the management of osteoporosis. Curr Med Res Opin. 2005;21:1015–26.PubMedCrossRef
48.
Zurück zum Zitat Chesnut CH 3rd, Bell NH, Clark GS, et al. Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med. 1997;102:29–37.PubMedCrossRef Chesnut CH 3rd, Bell NH, Clark GS, et al. Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med. 1997;102:29–37.PubMedCrossRef
49.
Zurück zum Zitat Delmas PD. The role of markers of bone turnover in the assessment of fracture risk in postmenopausal women. Osteoporosis Int. 1998;8(Suppl 1):S32–6.CrossRef Delmas PD. The role of markers of bone turnover in the assessment of fracture risk in postmenopausal women. Osteoporosis Int. 1998;8(Suppl 1):S32–6.CrossRef
50.
Zurück zum Zitat van Daele PL, Seibel MJ, Burger H, et al. Case-control-analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study. Brit Med J. 1996;312:482–3.PubMedCrossRef van Daele PL, Seibel MJ, Burger H, et al. Case-control-analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study. Brit Med J. 1996;312:482–3.PubMedCrossRef
51.
Zurück zum Zitat Pfeilschifter J, Kann PH. Diagnostik der Osteoporose. Z Gastroenterol. 2002;40:46–56.CrossRef Pfeilschifter J, Kann PH. Diagnostik der Osteoporose. Z Gastroenterol. 2002;40:46–56.CrossRef
52.
Zurück zum Zitat Stepan JJ. Clinical value of the biochemical markers of bone remodelling in the assessment of bone metabolic diseases. Jugoslov Med Biohem. 2006;25:241–8.CrossRef Stepan JJ. Clinical value of the biochemical markers of bone remodelling in the assessment of bone metabolic diseases. Jugoslov Med Biohem. 2006;25:241–8.CrossRef
53.
Zurück zum Zitat Bauer DC, Garnero P, Hochberg MC et al. Pretreatment levels of bone turnover and the antifracture efficacy of alendronate: the fracture Intervention trial. J Bone Miner Res. 2006;21:292–9.PubMedCrossRef Bauer DC, Garnero P, Hochberg MC et al. Pretreatment levels of bone turnover and the antifracture efficacy of alendronate: the fracture Intervention trial. J Bone Miner Res. 2006;21:292–9.PubMedCrossRef
54.
Zurück zum Zitat Kreihuber A. Osteoporosetherapie – aktueller Datenüberblick zu Raloxifen. J Miner Stoffwechs. 2008;15:220–2. Kreihuber A. Osteoporosetherapie – aktueller Datenüberblick zu Raloxifen. J Miner Stoffwechs. 2008;15:220–2.
55.
Zurück zum Zitat Maricic M, Adachi JD, Sarkar S, et al. Early effects of raloxifene on clinical vertebral fractures at 12 months in postmenopausal women with osteoporosis. Arch Intern Med. 2002;162:1140–3.PubMedCrossRef Maricic M, Adachi JD, Sarkar S, et al. Early effects of raloxifene on clinical vertebral fractures at 12 months in postmenopausal women with osteoporosis. Arch Intern Med. 2002;162:1140–3.PubMedCrossRef
56.
Zurück zum Zitat Cummings SR, San Martin J, McClung MR, et al. the FREEDOM trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009;361:756–65.PubMedCrossRef Cummings SR, San Martin J, McClung MR, et al. the FREEDOM trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009;361:756–65.PubMedCrossRef
57.
Zurück zum Zitat Jiang Y, Zhao JJ, Mitlak BH, et al. Recombinant human parathyroid hormone (1–34) (teriparatide) improves both cortical and cancellous bone structure. J Bone Miner Res. 2003;18:1932–41.PubMedCrossRef Jiang Y, Zhao JJ, Mitlak BH, et al. Recombinant human parathyroid hormone (1–34) (teriparatide) improves both cortical and cancellous bone structure. J Bone Miner Res. 2003;18:1932–41.PubMedCrossRef
58.
Zurück zum Zitat Neer RM, Arnaud CD, Zanchetta JR, et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344:1434–41.PubMedCrossRef Neer RM, Arnaud CD, Zanchetta JR, et al. Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344:1434–41.PubMedCrossRef
59.
Zurück zum Zitat Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004;350:459–68.PubMedCrossRef Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med. 2004;350:459–68.PubMedCrossRef
60.
Zurück zum Zitat Christgau S, Cloos PA. Current and future applications of bone turnover markers. Clin Lab. 2003;49:439–46.PubMed Christgau S, Cloos PA. Current and future applications of bone turnover markers. Clin Lab. 2003;49:439–46.PubMed
61.
Zurück zum Zitat Tonino RP, Meunier PJ, Emkey R, et al. Skeletal benefits of alendronate: 7-year treatment of postmenopausal osteoporotic women. J Clin Endocrinol Metab. 2000;85:3109–15PubMedCrossRef Tonino RP, Meunier PJ, Emkey R, et al. Skeletal benefits of alendronate: 7-year treatment of postmenopausal osteoporotic women. J Clin Endocrinol Metab. 2000;85:3109–15PubMedCrossRef
62.
Zurück zum Zitat Hochberg MC, Greenspan S, Wasnich RD, et al. Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab. 2002;87:1586–92.PubMedCrossRef Hochberg MC, Greenspan S, Wasnich RD, et al. Changes in bone density and turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. J Clin Endocrinol Metab. 2002;87:1586–92.PubMedCrossRef
63.
Zurück zum Zitat Bergmann P, Body JJ, Boonen S, et al. and Members of Advisory Board on Bone Markers. Evidence-based guidelines for the use of biochemical markers of bone turnover in the selection and monitoring of bisphosphonate treatment in osteoporosis: a consensus document of the Belgian Bone Club. Int J Clin Pract. 2009;63:19–26.PubMedCrossRef Bergmann P, Body JJ, Boonen S, et al. and Members of Advisory Board on Bone Markers. Evidence-based guidelines for the use of biochemical markers of bone turnover in the selection and monitoring of bisphosphonate treatment in osteoporosis: a consensus document of the Belgian Bone Club. Int J Clin Pract. 2009;63:19–26.PubMedCrossRef
64.
Zurück zum Zitat Bauer DC, Garnero P, Bilezikian JP, et al. Short-term changes in bone turnover markers and bone mineral density response to parathyroid hormone in postmenopausal women with osteoporosis. J Clin Endocrin Metab. 2006;91:1370–9.CrossRef Bauer DC, Garnero P, Bilezikian JP, et al. Short-term changes in bone turnover markers and bone mineral density response to parathyroid hormone in postmenopausal women with osteoporosis. J Clin Endocrin Metab. 2006;91:1370–9.CrossRef
65.
Zurück zum Zitat Dobnig H, Sipos A, Jiang Y, et al. Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy. J Clin Endocrinol Metab. 2005;90:3970–7.PubMedCrossRef Dobnig H, Sipos A, Jiang Y, et al. Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy. J Clin Endocrinol Metab. 2005;90:3970–7.PubMedCrossRef
66.
Zurück zum Zitat Black DM, Greenspan SL, Ensrud KE, et al. and PaTH Study Investigators. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003;349:1207–15.PubMedCrossRef Black DM, Greenspan SL, Ensrud KE, et al. and PaTH Study Investigators. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003;349:1207–15.PubMedCrossRef
67.
Zurück zum Zitat H, Cosman F, Endres DB, et al. Application of biochemical markers of bone turnover in the assessment and monitoring of bone diseases; Approved Guideline. In: NCCLS document C48-A (ISBN 1-56238-539-9) 2004; 24 (22). NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087–1898 USA. H, Cosman F, Endres DB, et al. Application of biochemical markers of bone turnover in the assessment and monitoring of bone diseases; Approved Guideline. In: NCCLS document C48-A (ISBN 1-56238-539-9) 2004; 24 (22). NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087–1898 USA.
68.
Zurück zum Zitat Bieglmayer C, Clodi M, Kudlacek S. Biomarker in der Osteologie: Aktueller Stand. J Miner Stoffwechs. 2006;13:82–7. Bieglmayer C, Clodi M, Kudlacek S. Biomarker in der Osteologie: Aktueller Stand. J Miner Stoffwechs. 2006;13:82–7.
69.
Zurück zum Zitat Ganero P. Markers of bone turnover in prostate cancer. Cancer Treatm Rev. 2001;27:187–92.CrossRef Ganero P. Markers of bone turnover in prostate cancer. Cancer Treatm Rev. 2001;27:187–92.CrossRef
70.
Zurück zum Zitat Jung K, Lein M, Stephan C, et al. Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications. In J Ca. 2004;111:783–91. Jung K, Lein M, Stephan C, et al. Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications. In J Ca. 2004;111:783–91.
71.
Zurück zum Zitat Brown JE, Thomson CS, Ellis SP, et al. Bone resorption predicts for skeletal complications in metastatic bone disease. Brit J Ca. 2003;89:2031–37.CrossRef Brown JE, Thomson CS, Ellis SP, et al. Bone resorption predicts for skeletal complications in metastatic bone disease. Brit J Ca. 2003;89:2031–37.CrossRef
72.
Zurück zum Zitat de la Piedra C, Castro-Errecaborde NA, Traba ML, et al. Bone remodelling markers in the detection of bone metastases in prostate cancer. Clin Chem Acta. 2003;331:45–53CrossRef de la Piedra C, Castro-Errecaborde NA, Traba ML, et al. Bone remodelling markers in the detection of bone metastases in prostate cancer. Clin Chem Acta. 2003;331:45–53CrossRef
73.
Zurück zum Zitat Koizumi M, Takahashi S, Ogata E. Bone metabolic markers in bisphosphonate therapy for skeletal metastases in patients with breast cancer. Breast Cancer. 2003;10:21–7.PubMedCrossRef Koizumi M, Takahashi S, Ogata E. Bone metabolic markers in bisphosphonate therapy for skeletal metastases in patients with breast cancer. Breast Cancer. 2003;10:21–7.PubMedCrossRef
74.
Zurück zum Zitat Brasso K, Christensen IJ, Johansen JS, et al. Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate. 2006;66:503–13.PubMedCrossRef Brasso K, Christensen IJ, Johansen JS, et al. Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Prostate. 2006;66:503–13.PubMedCrossRef
75.
Zurück zum Zitat Beke D, Kudlacek S, Meran JG. Klinische Relevanz von Biomarkern bei der Skelettmetastasierung von Malignomen. Wien Med Wochenschr. 2007;157:375–80.PubMedCrossRef Beke D, Kudlacek S, Meran JG. Klinische Relevanz von Biomarkern bei der Skelettmetastasierung von Malignomen. Wien Med Wochenschr. 2007;157:375–80.PubMedCrossRef
76.
Zurück zum Zitat Lipton A, Cook R, Saad F, et al. Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid. Cancer. 2008;113:193–201.PubMedCrossRef Lipton A, Cook R, Saad F, et al. Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid. Cancer. 2008;113:193–201.PubMedCrossRef
77.
Zurück zum Zitat Lipton A, Chapman JA, Demers L, et al. Elevated bone turnover predicts for bone metastasis in postmenopausal breast cancer: results of NCIC CTG MA.14. J Clin Oncol. 2011;29:3605–10.PubMedCrossRef Lipton A, Chapman JA, Demers L, et al. Elevated bone turnover predicts for bone metastasis in postmenopausal breast cancer: results of NCIC CTG MA.14. J Clin Oncol. 2011;29:3605–10.PubMedCrossRef
78.
Zurück zum Zitat Naylor KE, Iqbal P, Fledelius C, et al. The effect of pregnancy on bone density and bone turnover. J Bone Miner Res. 2000;15:129–37.PubMedCrossRef Naylor KE, Iqbal P, Fledelius C, et al. The effect of pregnancy on bone density and bone turnover. J Bone Miner Res. 2000;15:129–37.PubMedCrossRef
79.
Zurück zum Zitat Woitge HW, Friedmann B, Suttner S, et al. Changes in bone turnover induced by aerobic and anaerobic exercise in young males. J Bone Miner Res. 1998;13:1797–1804.PubMedCrossRef Woitge HW, Friedmann B, Suttner S, et al. Changes in bone turnover induced by aerobic and anaerobic exercise in young males. J Bone Miner Res. 1998;13:1797–1804.PubMedCrossRef
80.
Zurück zum Zitat Maïmoun L, Manetta J, Couret I, et al. The intensity level of physical exercise and the bone metabolism response. Int J Sports Med. 2006;27:105–111.PubMedCrossRef Maïmoun L, Manetta J, Couret I, et al. The intensity level of physical exercise and the bone metabolism response. Int J Sports Med. 2006;27:105–111.PubMedCrossRef
81.
Zurück zum Zitat Huber F, Traber L, Roth HJ, et al. Markers of bone resorption—measurement in serum, plasma or urine? Clin Lab. 2003;49:203–7.PubMed Huber F, Traber L, Roth HJ, et al. Markers of bone resorption—measurement in serum, plasma or urine? Clin Lab. 2003;49:203–7.PubMed
82.
Zurück zum Zitat Schmidt-Gayk H, Huber F, Traber L, et al. Vitamin-D-Versorgung und Marker des Knochenabbaus (b-CrossLaps) bei prä- und postmenopausalen Frauen. Osteoporose Rheuma aktuell. 2003;4:36–42. Schmidt-Gayk H, Huber F, Traber L, et al. Vitamin-D-Versorgung und Marker des Knochenabbaus (b-CrossLaps) bei prä- und postmenopausalen Frauen. Osteoporose Rheuma aktuell. 2003;4:36–42.
83.
Zurück zum Zitat Garnero P, Mulleman D, Munoz F, et al. Long-term variability of markers of bone turnover in postmenopausal women and implications for their clinical use: the OFELY study. J Bone Miner Res. 2003;18:1789–94.PubMedCrossRef Garnero P, Mulleman D, Munoz F, et al. Long-term variability of markers of bone turnover in postmenopausal women and implications for their clinical use: the OFELY study. J Bone Miner Res. 2003;18:1789–94.PubMedCrossRef
84.
Zurück zum Zitat Christgau S, Bitsch-Jensen O, Hanover Bjarnason N, et al. Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy. Bone. 2000;26:505–11.PubMedCrossRef Christgau S, Bitsch-Jensen O, Hanover Bjarnason N, et al. Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy. Bone. 2000;26:505–11.PubMedCrossRef
85.
Zurück zum Zitat Bjarnason NH, Henriksen EEG, Alexandersen P, et al. Mechanism of circadian variation in bone resorption. Bone. 2002;30:307–13.PubMedCrossRef Bjarnason NH, Henriksen EEG, Alexandersen P, et al. Mechanism of circadian variation in bone resorption. Bone. 2002;30:307–13.PubMedCrossRef
86.
Zurück zum Zitat Schmidt-Gayk H, Roth HJ, Becker S, et al. Noninvasive parameters of bone metabolism. Curr Opin Nephrol Hypertens. 1995 Jul;4:334–8.PubMedCrossRef Schmidt-Gayk H, Roth HJ, Becker S, et al. Noninvasive parameters of bone metabolism. Curr Opin Nephrol Hypertens. 1995 Jul;4:334–8.PubMedCrossRef
87.
Zurück zum Zitat Ohishi T, Takahashi M, Kushida K, et al. Changes of biochemical markers during fracture healing. Arch Orthop Trauma Surg. 1998;118:126–30.PubMedCrossRef Ohishi T, Takahashi M, Kushida K, et al. Changes of biochemical markers during fracture healing. Arch Orthop Trauma Surg. 1998;118:126–30.PubMedCrossRef
88.
Zurück zum Zitat Ingle BM, Hay SM, Bottjer HM, et al. Changes in bone mass and bone turnover following distal forearm fracture. Osteoporos Int. 1999;10:399–407.PubMedCrossRef Ingle BM, Hay SM, Bottjer HM, et al. Changes in bone mass and bone turnover following distal forearm fracture. Osteoporos Int. 1999;10:399–407.PubMedCrossRef
89.
Zurück zum Zitat Akesson K, Käkönen SM, Josefsson PO, et al. Fracture-induced changes in bone turnover: a potential confounder in the use of biochemical markers in osteoporosis. J Bone Miner Metab. 2005;23:30–5.PubMedCrossRef Akesson K, Käkönen SM, Josefsson PO, et al. Fracture-induced changes in bone turnover: a potential confounder in the use of biochemical markers in osteoporosis. J Bone Miner Metab. 2005;23:30–5.PubMedCrossRef
90.
Zurück zum Zitat Veitch SW, Findlay SC, Hamer AJ, et al. Changes in bone mass and bone turnover following tibial shaft fracture. Osteoporos Int. 2006;17:364–72.PubMedCrossRef Veitch SW, Findlay SC, Hamer AJ, et al. Changes in bone mass and bone turnover following tibial shaft fracture. Osteoporos Int. 2006;17:364–72.PubMedCrossRef
91.
Zurück zum Zitat Garnero P, Delmas PD. Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab. 1993;77:1046–53.PubMedCrossRef Garnero P, Delmas PD. Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab. 1993;77:1046–53.PubMedCrossRef
92.
Zurück zum Zitat Alvarez L, Guañabens N, Peris P, et al. Usefulness of biochemical markers of bone turnover in assessing response to the treatment of Paget’s disease. Bone 2001;29:447–52.PubMedCrossRef Alvarez L, Guañabens N, Peris P, et al. Usefulness of biochemical markers of bone turnover in assessing response to the treatment of Paget’s disease. Bone 2001;29:447–52.PubMedCrossRef
93.
Zurück zum Zitat Melkko J, Kauppila S, Niemi S, et al. Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem. 1996;42:947–54.PubMed Melkko J, Kauppila S, Niemi S, et al. Immunoassay for intact amino-terminal propeptide of human type I procollagen. Clin Chem. 1996;42:947–54.PubMed
94.
Zurück zum Zitat Bornstein P. The NH. (2)-terminal propeptides of fibrillar collagens: highly conserved domains with poorly understood functions. Matrix Biol. 2002;21:217–26.PubMedCrossRef Bornstein P. The NH. (2)-terminal propeptides of fibrillar collagens: highly conserved domains with poorly understood functions. Matrix Biol. 2002;21:217–26.PubMedCrossRef
95.
Zurück zum Zitat Tahtela R, Seppanen J, Laitinen K, et al. Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide. Osteoporos Int. 2005;16:1109–16.PubMedCrossRef Tahtela R, Seppanen J, Laitinen K, et al. Serum tartrate-resistant acid phosphatase 5b in monitoring bisphosphonate treatment with clodronate: a comparison with urinary N-terminal telopeptide of type I collagen and serum type I procollagen amino-terminal propeptide. Osteoporos Int. 2005;16:1109–16.PubMedCrossRef
96.
Zurück zum Zitat Chen P, Satterwhite JH, Licata AA, et al. Early changes in biochemical markers of bone formation predict BMD response to teriparatide in postmenopausal women with osteoporosis. J Bone Miner Res. 2005;20:962–70.PubMedCrossRef Chen P, Satterwhite JH, Licata AA, et al. Early changes in biochemical markers of bone formation predict BMD response to teriparatide in postmenopausal women with osteoporosis. J Bone Miner Res. 2005;20:962–70.PubMedCrossRef
97.
Zurück zum Zitat Schytte S, Hansen M, Moller S, et al. Hepatic and renal extraction of circulating type I procollagen aminopropeptide in patients with normal liver function and in patients with alcoholic cirrhosis. Scand J Clin Lab Invest. 1999;59:627–34.PubMedCrossRef Schytte S, Hansen M, Moller S, et al. Hepatic and renal extraction of circulating type I procollagen aminopropeptide in patients with normal liver function and in patients with alcoholic cirrhosis. Scand J Clin Lab Invest. 1999;59:627–34.PubMedCrossRef
98.
Zurück zum Zitat Hellman J, Kakonen SM, Matikainen MT, et al. Epitope mapping of nine monoclonal antibodies against osteocalcin: combinations into two-site assays affect both assay specificity and sample stability. J Bone Miner Res. 1996;11:1165–75.PubMedCrossRef Hellman J, Kakonen SM, Matikainen MT, et al. Epitope mapping of nine monoclonal antibodies against osteocalcin: combinations into two-site assays affect both assay specificity and sample stability. J Bone Miner Res. 1996;11:1165–75.PubMedCrossRef
99.
Zurück zum Zitat Takahashi M, Kushida K, Nagano A, et al. Comparison of the analytical and clinical performance characteristics of an N-MID versus an intact osteocalcin immunoradiometric assay. Clin Chim Acta. 2000;294:67–76.PubMedCrossRef Takahashi M, Kushida K, Nagano A, et al. Comparison of the analytical and clinical performance characteristics of an N-MID versus an intact osteocalcin immunoradiometric assay. Clin Chim Acta. 2000;294:67–76.PubMedCrossRef
100.
Zurück zum Zitat Durham BH, Robinson J, Fraser WD. Differences in the stability of intact osteocalcin in serum, lithium heparin plasma and EDTA plasma. Ann Clin Biochem. 1995;32:422–3.PubMed Durham BH, Robinson J, Fraser WD. Differences in the stability of intact osteocalcin in serum, lithium heparin plasma and EDTA plasma. Ann Clin Biochem. 1995;32:422–3.PubMed
101.
Zurück zum Zitat Noonan K, Kalu ME, Holownia P, et al. Effect of different storage temperatures, sample collection procedures and immunoassay methods on osteocalcin measurement. Eur J Clin Chem Clin Biochem. 1996;34:841–4.PubMed Noonan K, Kalu ME, Holownia P, et al. Effect of different storage temperatures, sample collection procedures and immunoassay methods on osteocalcin measurement. Eur J Clin Chem Clin Biochem. 1996;34:841–4.PubMed
102.
Zurück zum Zitat Colford J, Sailer D, Langman C. Five osteocalcin assays compared: tracer specificity, fragment interference, and calibration. Clin Chem. 1997;43:1240–1.PubMed Colford J, Sailer D, Langman C. Five osteocalcin assays compared: tracer specificity, fragment interference, and calibration. Clin Chem. 1997;43:1240–1.PubMed
103.
Zurück zum Zitat Vergnaud P, Garnero P, Meunier PJ, et al. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab. 1997;82:719–24.PubMedCrossRef Vergnaud P, Garnero P, Meunier PJ, et al. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab. 1997;82:719–24.PubMedCrossRef
104.
Zurück zum Zitat Holzer G, Grasse AV, Zehetmayer S, et al. Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: a pilot study. Transl Res. 2010;156:37–44.PubMedCrossRef Holzer G, Grasse AV, Zehetmayer S, et al. Vitamin K epoxide reductase (VKORC1) gene mutations in osteoporosis: a pilot study. Transl Res. 2010;156:37–44.PubMedCrossRef
105.
Zurück zum Zitat Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456–69.PubMedCrossRef Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130:456–69.PubMedCrossRef
106.
Zurück zum Zitat Fernández-Real JM, Izquierdo M, Ortega F, et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab. 2009;94:237–45.PubMedCrossRef Fernández-Real JM, Izquierdo M, Ortega F, et al. The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab. 2009;94:237–45.PubMedCrossRef
107.
Zurück zum Zitat Iki M, Tamaki J, Fujita Y, et al. Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo osteoporosis risk in men (FORMEN) Study. Osteoporos Int. 2011 Mar 25. Epub ahead of print. Iki M, Tamaki J, Fujita Y, et al. Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo osteoporosis risk in men (FORMEN) Study. Osteoporos Int. 2011 Mar 25. Epub ahead of print.
108.
Zurück zum Zitat Bonde M, Qvist P, Fledelius C, et al. Applications of an enzyme immunoassay for a new marker of bone resorption (CrossLaps): follow-up on hormone replacement therapy and osteoporosis risk assessment. J Clin Endocrinol Metab. 1995;80:864–8.PubMedCrossRef Bonde M, Qvist P, Fledelius C, et al. Applications of an enzyme immunoassay for a new marker of bone resorption (CrossLaps): follow-up on hormone replacement therapy and osteoporosis risk assessment. J Clin Endocrinol Metab. 1995;80:864–8.PubMedCrossRef
109.
Zurück zum Zitat Christgau S, Rosenquist C, Alexandersen P, et al. Clinical evaluation of the serum CrossLaps One Step ELISA, a new assay measuring the serum concentration of bone-derived degradation products from type I collagen C-telopetides. Clin Chem. 1998;44:2290–300.PubMed Christgau S, Rosenquist C, Alexandersen P, et al. Clinical evaluation of the serum CrossLaps One Step ELISA, a new assay measuring the serum concentration of bone-derived degradation products from type I collagen C-telopetides. Clin Chem. 1998;44:2290–300.PubMed
110.
Zurück zum Zitat Ganero P, Borel O, Delmas PD. Evaluation of a fully automated serum assay for C-terminal cross-linking telopeptide of type I collagen in osteoporosis. Clin Chem. 2001;47:694–702. Ganero P, Borel O, Delmas PD. Evaluation of a fully automated serum assay for C-terminal cross-linking telopeptide of type I collagen in osteoporosis. Clin Chem. 2001;47:694–702.
111.
Zurück zum Zitat Ravn P, Clemmesen B, Riis BJ, et al. The effect on bone mass and bone markers of different doses of Ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis. A 1-year, randomized, double-blind, placebo-controlled dose-finding study. Bone 1996;19:527–33.PubMedCrossRef Ravn P, Clemmesen B, Riis BJ, et al. The effect on bone mass and bone markers of different doses of Ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis. A 1-year, randomized, double-blind, placebo-controlled dose-finding study. Bone 1996;19:527–33.PubMedCrossRef
112.
Zurück zum Zitat Delmas PD, Adami S, Strugula C, et al. Intravenous Ibandronate Injections in postmenopausal women with osteoporosis. Arthritis Rheum. 2006;54:1838–46.PubMedCrossRef Delmas PD, Adami S, Strugula C, et al. Intravenous Ibandronate Injections in postmenopausal women with osteoporosis. Arthritis Rheum. 2006;54:1838–46.PubMedCrossRef
113.
Zurück zum Zitat Reginster J-Y, Adami S, Lakatos P, et al. Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study. Ann Rheum Dis. 2006;65:654–61.PubMedCrossRef Reginster J-Y, Adami S, Lakatos P, et al. Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study. Ann Rheum Dis. 2006;65:654–61.PubMedCrossRef
114.
Zurück zum Zitat Halleen JM, Raisanen S, Salo JJ, et al. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem. 1999;274:22907–10.PubMedCrossRef Halleen JM, Raisanen S, Salo JJ, et al. Intracellular fragmentation of bone resorption products by reactive oxygen species generated by osteoclastic tartrate-resistant acid phosphatase. J Biol Chem. 1999;274:22907–10.PubMedCrossRef
115.
Zurück zum Zitat Janckila AJ, Nakasato YR, Neustadt DH, et al. Disease-specific expression of tartrate-resistant acid phosphatase isoforms. J Bone Miner Res. 2003;18:1916–9.PubMedCrossRef Janckila AJ, Nakasato YR, Neustadt DH, et al. Disease-specific expression of tartrate-resistant acid phosphatase isoforms. J Bone Miner Res. 2003;18:1916–9.PubMedCrossRef
116.
Zurück zum Zitat Halleen JM, Alatalo SL, Janckila AJ, et al. Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption. Clin Chem. 2001;47:597–600.PubMed Halleen JM, Alatalo SL, Janckila AJ, et al. Serum tartrate-resistant acid phosphatase 5b is a specific and sensitive marker of bone resorption. Clin Chem. 2001;47:597–600.PubMed
117.
Zurück zum Zitat Hannon RA, Clowes JA, Eagleton AC, et al. Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption. Bone 2004;34:187–94.PubMedCrossRef Hannon RA, Clowes JA, Eagleton AC, et al. Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption. Bone 2004;34:187–94.PubMedCrossRef
118.
Zurück zum Zitat 103 K/DOQI guidelines for the management of renal osteodystrophy. Am J Kidney Dis. 2003;42(Suppl 3):S1–201. 103 K/DOQI guidelines for the management of renal osteodystrophy. Am J Kidney Dis. 2003;42(Suppl 3):S1–201.
119.
Zurück zum Zitat Souberbielle J-C, Boutten A, Carlier M-C, et al. Inter-method variability in PTH measurement: implication for the care of CKD patients. Kidney Int. 2006;70:345–50.PubMedCrossRef Souberbielle J-C, Boutten A, Carlier M-C, et al. Inter-method variability in PTH measurement: implication for the care of CKD patients. Kidney Int. 2006;70:345–50.PubMedCrossRef
120.
Zurück zum Zitat Woitge HW, Knothe A, Witte K, et al. Circannual rhythmus and interactions of vitamin D metabolites, parathyroid hormone, and biochemical markers of skeletal homeostasis: a prospective study. JBMR. 2000;15:2443–50.CrossRef Woitge HW, Knothe A, Witte K, et al. Circannual rhythmus and interactions of vitamin D metabolites, parathyroid hormone, and biochemical markers of skeletal homeostasis: a prospective study. JBMR. 2000;15:2443–50.CrossRef
121.
Zurück zum Zitat Dawson-Hughes B, Mithal A, Bonjour JP, et al. IOF position statement: vitamin D recommendations for older adults. Osteporos Int. 2010;21:1151–4.CrossRef Dawson-Hughes B, Mithal A, Bonjour JP, et al. IOF position statement: vitamin D recommendations for older adults. Osteporos Int. 2010;21:1151–4.CrossRef
122.
Zurück zum Zitat Ross AC, Manson JE, Abrams SA, et al. The 2011 Report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53–8.PubMedCrossRef Ross AC, Manson JE, Abrams SA, et al. The 2011 Report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53–8.PubMedCrossRef
Metadaten
Titel
Biomarkers of bone turnover in diagnosis and therapy of osteoporosis
A consensus advice from an Austrian working group
verfasst von
Univ.-Prof. Christian Bieglmayer, Ph.D.
Univ.-Prof. Hans Peter Dimai, M.D.
Univ.-Prof. Rudolf Wolfgang Gasser, M.D.
Univ.-Doz. Stefan Kudlacek, M.D.
Univ.-Prof. Barbara Obermayer-Pietsch, M.D.
Univ.-Prof. Wolfgang Woloszczuk, Ph.D.
Elisabeth Zwettler, M.D.
Univ.-Prof. Andrea Griesmacher, M.D.
Publikationsdatum
01.11.2012
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 21-22/2012
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-012-0133-9

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